GSTM3 and GSTM1

Number of citations of the paper that reports this interaction (PubMedID 24722188)
69

Data Source:
BioGRID (two hybrid)

		GSTM3	GSTM1
Description		glutathione S-transferase mu 3	glutathione S-transferase mu 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Sperm Fibrous Sheath Extracellular Exosome	Cytoplasm Cytosol
	Molecular Function	Glutathione Transferase Activity Protein Binding Transferase Activity Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Glutathione Binding	Glutathione Transferase Activity Transferase Activity Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Glutathione Binding
	Biological Process	Glutathione Metabolic Process Establishment Of Blood-nerve Barrier Nitrobenzene Metabolic Process Xenobiotic Catabolic Process Response To Estrogen Cellular Detoxification Of Nitrogen Compound	Lipid Metabolic Process Prostaglandin Metabolic Process Glutathione Metabolic Process Nitrobenzene Metabolic Process Xenobiotic Catabolic Process Hepoxilin Biosynthetic Process Cellular Detoxification Of Nitrogen Compound Glutathione Derivative Biosynthetic Process
Pathways		Glutathione conjugation	Glutathione conjugation Azathioprine ADME Paracetamol ADME
Drugs		Glutathione Glutathione disulfide Deoxycholic acid	Glutathione Chloroquine (9R,10R)-9-(S-glutathionyl)-10-hydroxy-9,10-dihydrophenanthrene Zinc trihydroxide S-(2,4-dinitrophenyl)glutathione Glutathione disulfide 5-fluorotryptophan Deoxycholic acid (9S,10S)-9-(S-glutathionyl)-10-hydroxy-9,10-dihydrophenanthrene
Diseases
GWAS		Alcohol dependence ( 33290381) Blood protein levels ( 30072576)	Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Bladder cancer ( 20972438) Blood protein levels ( 30072576) Liver enzyme levels (alanine transaminase) ( 33972514) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Platelet count ( 32888494)
Interacting Genes		8 interacting genes: CLVS2 GSTM1 GSTM2 GSTM4 OGT SH3GL2 UCHL5 YWHAE	3 interacting genes: GSTM2 GSTM3 MAP3K5
Entrez ID		2947	2944
HPRD ID		00712	00707
Ensembl ID		ENSG00000134202	ENSG00000134184
Uniprot IDs		P21266 Q6FGJ9	P09488 X5D932 X5DR03
PDB IDs		3GTU	1GTU 1XW6 1XWK 1YJ6 2F3M 7BEU 8VOU
Enriched GO Terms of Interacting Partners?		Nitrobenzene Metabolic Process Glutathione Binding Benzene-containing Compound Metabolic Process Xenobiotic Catabolic Process Glutathione Transferase Activity Long-chain Fatty Acid Biosynthetic Process Detoxification Of Nitrogen Compound Cellular Detoxification Of Nitrogen Compound Glutathione Metabolic Process Hepoxilin Biosynthetic Process Long-chain Fatty Acid Metabolic Process Xenobiotic Metabolic Process Fatty Acid Biosynthetic Process Calcium Channel Inhibitor Activity Enzyme Binding Modified Amino Acid Metabolic Process Catabolic Process Sulfur Compound Metabolic Process Carboxylic Acid Biosynthetic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Fatty Acid Metabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Lipid Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Identical Protein Binding Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Unsaturated Fatty Acid Metabolic Process Small Molecule Biosynthetic Process Regulation Of Heart Rate By Hormone Monocarboxylic Acid Metabolic Process Cellular Detoxification Lipid Biosynthetic Process Negative Regulation Of Blood-brain Barrier Permeability Negative Regulation Of Protein Catabolic Process Protein O-acetylglucosaminyltransferase Activity Cytosol Transmembrane Transporter Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Glutathione Derivative Biosynthetic Process Negative Regulation Of Proteolysis Regulation Of Calcium Ion Transmembrane Transport Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Leukotriene-C4 Synthase Activity Regulation Of Heart Rate By Chemical Signal Negative Regulation Of Calcium Ion Export Across Plasma Membrane Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Calcium Ion Export Across Plasma Membrane	Nitrobenzene Metabolic Process Detoxification Of Nitrogen Compound Cellular Detoxification Of Nitrogen Compound Glutathione Binding Benzene-containing Compound Metabolic Process Glutathione Transferase Activity Xenobiotic Catabolic Process Glutathione Metabolic Process Protein Homodimerization Activity Xenobiotic Metabolic Process Cellular Detoxification Modified Amino Acid Metabolic Process Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Establishment Of Blood-nerve Barrier Protein Kinase Complex Sulfur Compound Metabolic Process IRE1-TRAF2-ASK1 Complex Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Transferase Activity Hepoxilin Biosynthetic Process Identical Protein Binding Sperm Fibrous Sheath Regulation Of Skeletal Muscle Contraction By Calcium Ion Signaling Enzyme Binding JUN Kinase Kinase Kinase Activity Cellular Response To Caffeine Endothelial Cell Apoptotic Process Cellular Response To Purine-containing Compound Relaxation Of Cardiac Muscle Calcium Channel Inhibitor Activity Response To Caffeine Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Cellular Response To Reactive Nitrogen Species Regulation Of Skeletal Muscle Contraction Relaxation Of Muscle Linoleic Acid Metabolic Process Glutathione Peroxidase Activity Programmed Necrotic Cell Death Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress MAP Kinase Kinase Kinase Activity Stress-activated MAPK Cascade Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Stress-activated Protein Kinase Signaling Cascade P38MAPK Cascade Positive Regulation Of P38MAPK Cascade Fatty Acid Binding Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Alkaloid Long-chain Fatty Acid Biosynthetic Process
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