GSTM3 and GSTM2

Number of citations: 25 (PubMedID 1530570)
Data Source: HPRD (in vitro)

		GSTM3	GSTM2
Name		glutathione S-transferase mu 3	glutathione S-transferase mu 2
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Sperm Fibrous Sheath Extracellular Exosome	Cytoplasm Cytosol Sarcoplasmic Reticulum Extracellular Exosome
	Molecular Function	Glutathione Transferase Activity Protein Binding Transferase Activity Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Glutathione Binding	Glutathione Transferase Activity Glutathione Peroxidase Activity Fatty Acid Binding Protein Binding Transferase Activity Calcium Channel Inhibitor Activity Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Glutathione Binding Transmembrane Transporter Binding
	Biological Process	Glutathione Metabolic Process Establishment Of Blood-nerve Barrier Nitrobenzene Metabolic Process Xenobiotic Catabolic Process Response To Estrogen Cellular Detoxification Of Nitrogen Compound	Lipid Metabolic Process Glutathione Metabolic Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Nitrobenzene Metabolic Process Xenobiotic Catabolic Process Linoleic Acid Metabolic Process Hepoxilin Biosynthetic Process Relaxation Of Cardiac Muscle Cellular Detoxification Of Nitrogen Compound Cellular Response To Caffeine Cellular Oxidant Detoxification
Pathways		Glutathione conjugation	Glutathione conjugation
Drugs		Glutathione Glutathione disulfide Deoxycholic acid	Glutathione S-(2,4-dinitrophenyl)glutathione Glutathione disulfide Glutathione disulfide Deoxycholic acid S-Methyl glutathione
GWAS		Alcohol dependence ( 33290381 ) Blood protein levels ( 30072576 )	Apolipoprotein A1 levels ( 32203549 ) Apolipoprotein B levels ( 32203549 ) HDL cholesterol levels ( 32203549 ) LDL cholesterol levels ( 32203549 ) Metabolite levels ( 31628463 ) Urinary metabolite levels in chronic kidney disease ( 31959995 )
Interacting Genes		8 interacting genes: CLVS2 GSTM1 GSTM2 GSTM4 OGT SH3GL2 UCHL5 YWHAE	3 interacting genes: GSTM1 GSTM3 PTEN
Entrez ID		2947	2946
HPRD ID		00712	00710
Ensembl ID		ENSG00000134202	ENSG00000213366
Uniprot IDs		P21266 Q6FGJ9	P28161 Q0D2I8
PDB IDs		3GTU	1HNA 1HNB 1HNC 1XW5 1YKC 2AB6 2C4J 2GTU 3GTU 3GUR 5HWL
GO Terms Enriched among Interactors		Nitrobenzene Metabolic Process Glutathione Binding Benzene-containing Compound Metabolic Process Xenobiotic Catabolic Process Glutathione Transferase Activity Long-chain Fatty Acid Biosynthetic Process Detoxification Of Nitrogen Compound Cellular Detoxification Of Nitrogen Compound Glutathione Metabolic Process Hepoxilin Biosynthetic Process Long-chain Fatty Acid Metabolic Process Xenobiotic Metabolic Process Fatty Acid Biosynthetic Process Calcium Channel Inhibitor Activity Enzyme Binding Modified Amino Acid Metabolic Process Catabolic Process Sulfur Compound Metabolic Process Carboxylic Acid Biosynthetic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Fatty Acid Metabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Lipid Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Identical Protein Binding Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Unsaturated Fatty Acid Metabolic Process Small Molecule Biosynthetic Process Regulation Of Heart Rate By Hormone Monocarboxylic Acid Metabolic Process Cellular Detoxification Lipid Biosynthetic Process Negative Regulation Of Blood-brain Barrier Permeability Negative Regulation Of Protein Catabolic Process Protein O-acetylglucosaminyltransferase Activity Cytosol Transmembrane Transporter Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Glutathione Derivative Biosynthetic Process Negative Regulation Of Proteolysis Regulation Of Calcium Ion Transmembrane Transport Regulation Of Skeletal Muscle Contraction By Regulation Of Release Of Sequestered Calcium Ion Leukotriene-C4 Synthase Activity Regulation Of Heart Rate By Chemical Signal Negative Regulation Of Calcium Ion Export Across Plasma Membrane Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Calcium Ion Export Across Plasma Membrane	Nitrobenzene Metabolic Process Detoxification Of Nitrogen Compound Cellular Detoxification Of Nitrogen Compound Glutathione Binding Benzene-containing Compound Metabolic Process Glutathione Transferase Activity Xenobiotic Catabolic Process Enzyme Binding Glutathione Metabolic Process Xenobiotic Metabolic Process Cellular Detoxification Negative Regulation Of Synaptic Vesicle Clustering Modified Amino Acid Metabolic Process Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Establishment Of Blood-nerve Barrier Central Nervous System Myelin Maintenance Rhythmic Synaptic Transmission Sulfur Compound Metabolic Process Glutathione Derivative Biosynthetic Process Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Phosphatidylinositol Phosphate Phosphatase Activity Identical Protein Binding Hepoxilin Biosynthetic Process Sperm Fibrous Sheath Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Clustering Postsynaptic Density Assembly Neuron-neuron Synaptic Transmission Negative Regulation Of Cell Size Anaphase-promoting Complex Binding Forebrain Morphogenesis Presynaptic Membrane Assembly Presynaptic Membrane Organization Postsynaptic Specialization Assembly Schmidt-Lanterman Incisure Negative Regulation Of Excitatory Postsynaptic Potential Locomotor Rhythm Cellular Response To Electrical Stimulus Ubiquitin Ligase Activator Activity Spindle Assembly Involved In Female Meiosis Maternal Behavior Phosphatidylinositol-3-phosphate Phosphatase Activity Prepulse Inhibition Meiotic Spindle Assembly Myelin Maintenance