MAPKAP1 and ABCB1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		MAPKAP1	ABCB1
Gene Name		mitogen-activated protein kinase associated protein 1	ATP-binding cassette, sub-family B (MDR/TAP), member 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cytoplasmic Membrane-bounded Vesicle	Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Ras GTPase Binding Protein Kinase Binding Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding	Transporter Activity Protein Binding ATP Binding Xenobiotic-transporting ATPase Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances
	Biological Process	Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Substantia Nigra Development T Cell Costimulation Fc-epsilon Receptor Signaling Pathway Innate Immune Response Negative Regulation Of Ras Protein Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling	G2/M Transition Of Mitotic Cell Cycle Transport Drug Transmembrane Transport Response To Drug Xenobiotic Transport Small Molecule Metabolic Process Transmembrane Transport Stem Cell Proliferation
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Costimulation by the CD28 family PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer VEGFA-VEGFR2 Pathway Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling VEGFR2 mediated vascular permeability Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Signaling by VEGF Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System	ABC-family proteins mediated transport Abacavir transmembrane transport Abacavir transport and metabolism
Drugs			Adenosine triphosphate Roxithromycin Voacamine
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ABCB1 AKT1S1 CDC42EP1 ECI1 EIF4EBP1 MAPK8 PRR5L YWHAG	10 interactors: BCCIP CAV1 CD4 HAX1 LNX1 MAPKAP1 MAPRE1 PIM1 PSMB8 RNF2
Entrez ID		79109	5243
HPRD ID		17464	01370
Ensembl ID		ENSG00000119487	ENSG00000085563
Uniprot IDs		Q9BPZ7	A4D1D2 P08183
PDB IDs		3VOQ
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction TOR Signaling Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Protein Phosphorylation Positive Regulation Of Mitochondrion Organization Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Phosphorylation Positive Regulation Of Organelle Organization Regulation Of Protein Metabolic Process Regulation Of Mitochondrion Organization TORC2 Signaling G2/M Transition Of Mitotic Cell Cycle Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Mitotic Cell Cycle Process Regulation Of Signaling Mitotic Cell Cycle IRES-dependent Translational Initiation Cap-independent Translational Initiation JUN Phosphorylation Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Xenobiotic Transport Positive Regulation Of Deacetylase Activity Cellular Response To Organic Substance Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Negative Regulation Of Protein Kinase Activity Regulation Of Cellular Component Organization Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Determination Of Dorsal Identity Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Kinase Activity Positive Regulation Of Intracellular Transport Regulation Of Organelle Organization Signaling Negative Regulation Of Cellular Metabolic Process Response To Stimulus Cytoplasmic Translational Initiation Fc Receptor Signaling Pathway Cell Communication Cell Cycle Process	T Cell Costimulation Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Cellular Ketone Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Cell Cycle Positive Regulation Of Cell-cell Adhesion Mitotic Cell Cycle Phase Transition Positive Regulation Of Protein Phosphorylation Cell Cycle Phase Transition Regulation Of Protein Kinase Activity Mitotic Cell Cycle Regulation Of Phosphorus Metabolic Process Regulation Of T Cell Activation Regulation Of Kinase Activity Positive Regulation Of Cell Activation Positive Regulation Of Phosphorylation Positive Regulation Of Immune System Process Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Membrane Repolarization During Action Potential Negative Regulation Of Peptidyl-tyrosine Autophosphorylation Induction By Virus Of Host Cell-cell Fusion Protein Palmitoleylation Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Lymphocyte Activation Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Protein Ubiquitination Regulation Of Cell Activation Nitric Oxide Homeostasis Histone H2A-K119 Monoubiquitination Regulation Of Peptidyl-serine Phosphorylation Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Canonical Wnt Signaling Pathway Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Positive Regulation Of Microtubule Plus-end Binding Regulation Of Inward Rectifier Potassium Channel Activity Positive Regulation Of Signal Transduction Viral Process Positive Regulation Of Transferase Activity Regulation Of Immune System Process
Tagcloud ?			abcg2 arg72pro arg952lys asp1853asn atm atp7b backgroundovarian chances conclusionsthe emphasized facts gstm1 gstp1 gstt1 ile1145 inverted mark mark0 methodsin pgr question resultsten ser406ala ser894ala underscore unfavorable val660leu xenobiotics
Tagcloud (Difference) ?			abcg2 arg72pro arg952lys asp1853asn atm atp7b backgroundovarian chances conclusionsthe emphasized facts gstm1 gstp1 gstt1 ile1145 inverted mark mark0 methodsin pgr question resultsten ser406ala ser894ala underscore unfavorable val660leu xenobiotics
Tagcloud (Intersection) ?