MAPKAP1 and MLST8

Number of citations of the paper that reports this interaction (PubMedID 37688978)
55

Data Source:
BioGRID (pull down, affinity chromatography technology, affinity chromatography technology)

		MAPKAP1	MLST8
Description		MAPK associated protein 1	MTOR associated protein MLST8
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GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Cilium Membrane Early Endosome Membrane Late Endosome Membrane TORC2 Complex Perinuclear Region Of Cytoplasm Serine/threonine Protein Kinase Complex	Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane TORC1 Complex TORC2 Complex Serine/threonine Protein Kinase Complex
	Molecular Function	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Kinase Binding Small GTPase Binding Phosphatidylinositol-3,4-bisphosphate Binding Molecular Adaptor Activity Phosphatidic Acid Binding Phosphatidylinositol-3,5-bisphosphate Binding Enzyme-substrate Adaptor Activity	Protein Binding Protein-macromolecule Adaptor Activity Protein Serine/threonine Kinase Activator Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Cytoskeleton Organization Insulin Receptor Signaling Pathway Substantia Nigra Development Positive Regulation Of Cell Growth Cellular Response To Nutrient Levels Cellular Response To Insulin Stimulus TORC2 Signaling Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Insulin Receptor Signaling Pathway Protein Stabilization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cellular Response To Oxidative Stress	DNA Damage Response Cytoskeleton Organization Negative Regulation Of Autophagy Positive Regulation Of Cell Growth Positive Regulation Of Actin Filament Polymerization Cellular Response To Nutrient Levels TOR Signaling Positive Regulation Of TOR Signaling Regulation Of Actin Cytoskeleton Organization TORC1 Signaling TORC2 Signaling Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Glycolytic Process Positive Regulation Of Lipid Biosynthetic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Hypoxia Cellular Response To Osmotic Stress Positive Regulation Of Pentose-phosphate Shunt
Pathways		PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	PIP3 activates AKT signaling Macroautophagy MTOR signalling mTORC1-mediated signalling HSF1-dependent transactivation Energy dependent regulation of mTOR by LKB1-AMPK CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Regulation of PTEN gene transcription Amino acids regulate mTORC1 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs
Diseases
GWAS		Body mass index ( 28892062) Diverticular disease ( 30177863) Fish- and plant-related diet ( 32066663) Gut microbiota relative abundance (Ruminococcus belonging to family Lachnospiraceae) ( 33208821) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Medication use (calcium channel blockers) ( 31015401) Raw vegetable consumption ( 32066663) Resting heart rate ( 27798624) Sleep duration ( 30531941) Smoking status (ever vs never smokers) ( 30643258)	Height ( 28552196)
Interacting Genes		12 interacting genes: ABCB1 AKT1 CDC42EP1 ECI1 MAPK8 MLST8 MTOR NRAS PRKCA SGK1 UBC YWHAG	13 interacting genes: A2M APPL2 ATXN1 CDK1 CDK2 EIF4EBP1 KEAP1 LCOR MAPKAP1 MTOR PRMT1 RPS6KA3 RPTOR
Entrez ID		79109	64223
HPRD ID		17464	17031
Ensembl ID		ENSG00000119487	ENSG00000167965
Uniprot IDs		Q9BPZ7	H3BPT1 Q9BVC4
PDB IDs		3VOQ 5ZCS 6ZWM 6ZWO 7LC1 7LC2 7PE7 7PE8 7PE9 7TZO 7VV8 7VV9 7VVB 7VVG	4JSN 4JSP 4JSV 4JSX 4JT5 4JT6 5FLC 5H64 5WBU 5WBY 5ZCS 6BCU 6BCX 6SB0 6SB2 6ZWM 6ZWO 7OWG 7PE7 7PE8 7PE9 7PEA 7PEB 7PEC 7TZO 7UXC 7UXH 8ERA 8RCH 8RCK 9F44 9F45
Enriched GO Terms of Interacting Partners?		Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation TORC1 Signaling TOR Signaling Intracellular Signal Transduction Positive Regulation Of TOR Signaling Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Nutrient Levels Positive Regulation Of Cellular Component Biogenesis Intracellular Signaling Cassette Cellular Response To Nutrient Levels Response To Peptide Hormone Response To Hormone Cellular Response To Hormone Stimulus Protein Serine Kinase Activity Regulation Of TOR Signaling Positive Regulation Of Pentose-phosphate Shunt Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Protein Serine/threonine Kinase Activity Cellular Response To Osmotic Stress Positive Regulation Of Actin Filament Polymerization Regulation Of Biological Quality Negative Regulation Of Translation Cellular Response To Starvation TORC1 Complex Regulation Of Pentose-phosphate Shunt SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein-containing Complex Assembly Cellular Response To Oxygen-containing Compound Negative Regulation Of TORC1 Signaling Response To Ketone Positive Regulation Of TORC1 Signaling Response To Starvation Regulation Of NADP Metabolic Process Protein Kinase Activity Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Response To Osmotic Stress TORC2 Complex Response To Alcohol Modification-dependent Protein Catabolic Process Positive Regulation Of Protein Polymerization Cellular Response To Chemical Stress Cellular Response To Stress Anoikis Negative Regulation Of TOR Signaling Post-transcriptional Regulation Of Gene Expression Mitochondrion Positive Regulation Of Endothelial Cell Proliferation Regulation Of TORC2 Signaling	TOR Signaling Negative Regulation Of Translational Initiation TORC1 Signaling Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Serine/threonine Protein Kinase Complex Positive Regulation Of Growth Negative Regulation Of Macromolecule Metabolic Process Regulation Of Translational Initiation Cellular Response To Oxygen-containing Compound Cyclin-dependent Protein Kinase Activity Negative Regulation Of Metabolic Process Positive Regulation Of Pentose-phosphate Shunt Regulation Of Cell Differentiation Positive Regulation Of Cell Growth Negative Regulation Of Cellular Response To Insulin Stimulus Histone Kinase Activity TORC1 Complex Regulation Of Pentose-phosphate Shunt Cellular Response To Methionine Negative Regulation Of Translation Regulation Of Translation Intracellular Signal Transduction Response To Methionine Regulation Of NADP Metabolic Process Positive Regulation Of TORC1 Signaling TORC2 Complex Regulation Of Mitotic Cell Cycle Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression G1/S Transition Of Mitotic Cell Cycle Regulation Of Multicellular Organismal Development Cellular Response To Amino Acid Stimulus Cell Cycle G1/S Phase Transition Cellular Response To Nutrient Levels Regulation Of Macromolecule Biosynthetic Process Cellular Response To L-leucine Positive Regulation Of TOR Signaling Cellular Response To Chemical Stress Regulation Of Primary Metabolic Process Regulation Of Protein Metabolic Process Regulation Of TORC1 Signaling Regulation Of Growth Post-transcriptional Regulation Of Gene Expression TORC2 Signaling Response To L-leucine Nucleoplasm Positive Regulation Of Transcription By RNA Polymerase III Enzyme-substrate Adaptor Activity
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