PDK1 and USP4

Number of citations of the paper that reports this interaction (PMID 22347420)
1

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		PDK1	USP4
Gene Name		pyruvate dehydrogenase kinase, isozyme 1	ubiquitin specific peptidase 4 (proto-oncogene)
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Mitochondrial Pyruvate Dehydrogenase Complex	Nucleus Cytoplasm Lysosome Plasma Membrane
	Molecular Function	Protein Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Adenosine Receptor Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Glucose Metabolic Process Pyruvate Metabolic Process Protein Phosphorylation Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Glucose Metabolic Process Cellular Metabolic Process Small Molecule Metabolic Process Hypoxia-inducible Factor-1alpha Signaling Pathway	Spliceosomal Tri-snRNP Complex Assembly Protein Deubiquitination Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Protein Localization To Cell Surface Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Signaling by Retinoic Acid Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport
Drugs
Diseases
GWAS		Erectile dysfunction ( 22704111)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		9 interactors: DLAT KAT2B PDHA1 PDK2 RPS6KB1 SGK1 USP4 XRCC6 YWHAQ	46 interactors: AKT1 ANXA7 ASS1 ATP1B1 ATP1B3 BRAP CDKN1A FAM96B HUWE1 IGKV2D-29 LAMA5 LGALS1 NLK NOLC1 NPC2 PCNA PDK1 PGM1 PLA2G2A PLOD1 PPIA PRPF3 PSAP PSMA6 PSMC5 PSMD11 RB1 RBL1 RBL2 RCC1 SART3 SMN1 TCF4 TGFBR1 TK1 TP53BP2 TRAF2 TRAF6 TRIM21 TRIM54 TRIM55 TRIM63 UBC USP15 USP21 USP28
Entrez ID		5163	7375
HPRD ID		03954	04598
Ensembl ID			ENSG00000114316
Uniprot IDs		B7Z937 E9PD65 Q15118	Q08AK7 Q13107
PDB IDs		2Q8F 2Q8G 2Q8H	2Y6E
Enriched GO Terms of Interacting Partners?		Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Acyl-CoA Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Pyruvate Metabolic Process Glucose Metabolic Process Regulation Of Cellular Ketone Metabolic Process Regulation Of Metabolic Process Hexose Metabolic Process Cellular Response To Insulin Stimulus Monosaccharide Metabolic Process Tricarboxylic Acid Cycle Regulation Of Gluconeogenesis Long-term Memory Citrate Metabolic Process Response To Insulin Regulation Of Lipid Metabolic Process Cellular Response To Peptide Hormone Stimulus Tricarboxylic Acid Metabolic Process Cellular Response To Peptide Aerobic Respiration Apoptotic Process Programmed Cell Death Cell Death Death Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Glucose Metabolic Process Histone H3-K9 Acetylation Regulation Of Protein ADP-ribosylation Positive Regulation Of Skeletal Muscle Tissue Growth Memory Monocarboxylic Acid Metabolic Process Cellular Response To Hormone Stimulus Cellular Hyperosmotic Salinity Response Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation N-terminal Peptidyl-lysine Acetylation Insulin Receptor Signaling Pathway Regulation Of Carbohydrate Metabolic Process Regulation Of Phosphorus Metabolic Process Renal Sodium Ion Absorption Acetyl-CoA Biosynthetic Process From Pyruvate Cellular Respiration Renal Sodium Ion Transport Skeletal Muscle Atrophy Regulation Of Cellular Process Cellular Response To X-ray Striated Muscle Atrophy Response To Leucine Intrinsic Apoptotic Signaling Pathway	G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Apoptotic Process Cell Cycle Response To Stress Programmed Cell Death Cell Death Death Response To Stimulus Protein Polyubiquitination Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Signal Transduction By P53 Class Mediator Positive Regulation Of Cell Cycle Protein Ubiquitination Mitotic Cell Cycle Protein Catabolic Process Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Immune System Process Proteasomal Protein Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Proteolysis Cell Cycle Process Regulation Of Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Response To Organic Substance Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Positive Regulation Of Proteolysis Regulation Of Lipid Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Negative Regulation Of Transferase Activity Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of Catalytic Activity Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Intracellular Signal Transduction Negative Regulation Of Cell Cycle Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Cell Cycle Checkpoint Cellular Response To Stimulus Mitotic G1 DNA Damage Checkpoint Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		additive arginine claims conceptus conceptuses cooperative cooperatively embryo extra fetus greatest histotroph implantation limitation mammals mtorc1 multifunctional otr1 ovine peri phosphoprotein pkb rgd rspp1 spp1 synergistic trophectoderm tsc2 uterine	1beta adaptor associates deubiquitinase deubiquitinates deubiquitination ectopic ikappabalpha importantly incompletely insight interact interacts kappab kappabalpha negatively nf polyubiquitination protease reporter signalling tnfalpha traf traf2 traf3 traf6 ubiquitin uncovers
Tagcloud (Difference) ?		additive arginine claims conceptus conceptuses cooperative cooperatively embryo extra fetus greatest histotroph implantation limitation mammals mtorc1 multifunctional otr1 ovine peri phosphoprotein pkb rgd rspp1 spp1 synergistic trophectoderm tsc2 uterine	1beta adaptor associates deubiquitinase deubiquitinates deubiquitination ectopic ikappabalpha importantly incompletely insight interact interacts kappab kappabalpha negatively nf polyubiquitination protease reporter signalling tnfalpha traf traf2 traf3 traf6 ubiquitin uncovers
Tagcloud (Intersection) ?