PDK1 and PDK2

Number of citations of the paper that reports this interaction (PubMedID 12573248)
0

Data Source:
HPRD (in vitro)

		PDK1	PDK2
Description		pyruvate dehydrogenase kinase 1	pyruvate dehydrogenase kinase 2
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex	Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Pyruvate Dehydrogenase Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity	Nucleotide Binding Protein Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Homodimerization Activity
	Biological Process	Glucose Metabolic Process Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Glucose Metabolic Process Cellular Response To Stress Hypoxia-inducible Factor-1alpha Signaling Pathway	Glucose Metabolic Process Regulation Of Gluconeogenesis Regulation Of PH Insulin Receptor Signaling Pathway Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Ketone Metabolic Process Regulation Of Glucose Metabolic Process Cellular Response To Nutrient Cellular Response To Stress Cellular Response To Reactive Oxygen Species Glucose Homeostasis Regulation Of Calcium-mediated Signaling Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid Mitochondrial protein degradation	Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid
Drugs		4-[(3-CHLORO-4-{[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]AMINO}PHENYL)SULFONYL]-N,N-DIMETHYLBENZAMIDE Dichloroacetic acid	4-({(2R,5S)-2,5-DIMETHYL-4-[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]PIPERAZIN-1-YL}CARBONYL)BENZONITRILE (2R)-N-{4-[Ethyl(phenyl)sulfamoyl]-2-methylphenyl}-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide N-(2-AMINOETHYL)-2-{3-CHLORO-4-[(4-ISOPROPYLBENZYL)OXY]PHENYL} ACETAMIDE
Diseases
GWAS		Erectile dysfunction in type 1 diabetes ( 22704111) Fasting plasma glucose ( 25187374)
Interacting Genes		16 interacting genes: AKT1 BIN1 DLAT FGFR1 ITGB3 KAT2B LAMTOR5 PDHA1 PDK2 PIK3CA RPS6KB1 SGK1 UBE2O USP4 XRCC6 YWHAQ	10 interacting genes: AKT1 DLAT HIC2 HTT ISOC2 PDHA1 PDHX PDK1 SGK1 VSIG4
Entrez ID		5163	5164
HPRD ID		03954	03955
Ensembl ID		ENSG00000152256	ENSG00000005882
Uniprot IDs		B7Z207 B7Z7N6 Q15118	Q15119
PDB IDs		2Q8F 2Q8G 2Q8H	2BTZ 2BU2 2BU5 2BU6 2BU7 2BU8 4MP2 4MP7 4MPC 4MPE 4MPN 4V25 4V26 5J6A 5J71 5M4K 5M4M 5M4N 5M4P 6LIL 6LIN 6LIO 6TMP 6TMQ 6TMZ 6TN0 6TN2 7EA0 7EAS 7EBH 7VBU 7VBV 7VBX 8ZM1 8ZM2
Enriched GO Terms of Interacting Partners?		Glucose Metabolic Process Monosaccharide Metabolic Process Hexose Metabolic Process Positive Regulation Of TOR Signaling Insulin Receptor Signaling Pathway Pyruvate Dehydrogenase Complex Carbohydrate Metabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of TOR Signaling Positive Regulation Of TORC1 Signaling TORC1 Signaling Cellular Response To Hormone Stimulus Cellular Response To Peptide Hormone Stimulus TOR Signaling Intracellular Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Phosphatidylinositol-mediated Signaling Regulation Of TORC1 Signaling Cellular Response To Insulin Stimulus Protein Serine/threonine/tyrosine Kinase Activity Regulation Of Programmed Cell Death Tricarboxylic Acid Cycle Cellular Response To Nutrient Levels Insulin-like Growth Factor Receptor Signaling Pathway Protein-containing Complex Cellular Response To Nutrient Response To Peptide Hormone Cellular Response To Oxygen-containing Compound Transferase Activity Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Translational Initiation Response To Hormone Phosphate-containing Compound Metabolic Process Response To Insulin Kinase Activity Pyruvate Decarboxylation To Acetyl-CoA ATP Binding Regulation Of Apoptotic Process Small Molecule Metabolic Process Negative Regulation Of TORC1 Signaling Regulation Of Intracellular Signal Transduction Pyruvate Metabolic Process Regulation Of Biological Quality Organic Acid Metabolic Process Response To Ketone Anoikis Positive Regulation Of Intracellular Signal Transduction Response To Activity Positive Regulation Of Signal Transduction	Pyruvate Dehydrogenase Complex Pyruvate Decarboxylation To Acetyl-CoA Acetyl-CoA Biosynthetic Process Dihydrolipoyllysine-residue Acetyltransferase Activity Glucose Metabolic Process Acetyl-CoA Metabolic Process Hexose Metabolic Process Monosaccharide Metabolic Process Pyruvate Metabolic Process Mitochondrion Acyl-CoA Metabolic Process Sulfur Compound Biosynthetic Process Carbohydrate Metabolic Process Phosphate-containing Compound Metabolic Process Mitochondrial Matrix Amide Biosynthetic Process Protein Serine/threonine/tyrosine Kinase Activity Tricarboxylic Acid Cycle Positive Regulation Of Cilium Assembly Protein Kinase Activity Positive Regulation Of Transporter Activity Purine-containing Compound Biosynthetic Process T Cell Costimulation Kinase Activity Sulfur Compound Metabolic Process Regulation Of TRNA Methylation Protein Destabilization Nucleoside Phosphate Biosynthetic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Regulation Of Cilium Assembly Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Organelle Assembly Regulation Of T Cell Activation Response To Insulin-like Growth Factor Stimulus Regulation Of Leukocyte Cell-cell Adhesion Protein Serine Kinase Activity Mammalian Oogenesis Stage Protein Phosphorylation Regulation Of Glucose Metabolic Process Kinase Binding TRNA (guanine-N7)-methylation Cellular Response To Rapamycin Small Molecule Metabolic Process Phosphorylation Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Protein Localization To Lysosome Protein Serine/threonine Kinase Activity Positive Regulation Of Endodeoxyribonuclease Activity Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
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