PDK1 and SGK1

Number of citations of the paper that reports this interaction (PubMedID 17314099)
0

Data Source:
BioGRID (enzymatic study)

		PDK1	SGK1
Description		pyruvate dehydrogenase kinase 1	serum/glucocorticoid regulated kinase 1
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Nuclear Speck
	Molecular Function	Nucleotide Binding Protein Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding Potassium Channel Regulator Activity Kinase Activity Transferase Activity Sodium Channel Regulator Activity Chloride Channel Regulator Activity Protein Serine Kinase Activity
	Biological Process	Glucose Metabolic Process Cell Population Proliferation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Glucose Metabolic Process Cellular Response To Stress Hypoxia-inducible Factor-1alpha Signaling Pathway	Regulation Of Cell Growth Protein Phosphorylation Sodium Ion Transport Apoptotic Process DNA Damage Response Long-term Memory Regulation Of Blood Pressure Regulation Of Cell Migration Positive Regulation Of Transporter Activity Intracellular Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Neuron Projection Morphogenesis Regulation Of Catalytic Activity Regulation Of DNA-binding Transcription Factor Activity Regulation Of Gastric Acid Secretion Renal Sodium Ion Absorption Regulation Of Signal Transduction By P53 Class Mediator Cellular Response To Aldosterone
Pathways		Regulation of pyruvate dehydrogenase (PDH) complex Signaling by Retinoic Acid Mitochondrial protein degradation	PIP3 activates AKT signaling Stimuli-sensing channels Regulation of TP53 Degradation Transcriptional Regulation by MECP2 NGF-stimulated transcription
Drugs		4-[(3-CHLORO-4-{[(2R)-3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANOYL]AMINO}PHENYL)SULFONYL]-N,N-DIMETHYLBENZAMIDE Dichloroacetic acid	Flavin mononucleotide [4-(5-naphthalen-2-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]acetic acid 4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid
Diseases
GWAS		Erectile dysfunction in type 1 diabetes ( 22704111) Fasting plasma glucose ( 25187374)	Blond vs. brown/black hair color ( 30531825) Body mass index (smoking years interaction) ( 23192594) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) Pelvic organ prolapse ( 26545240) Pelvic organ prolapse (moderate/severe) ( 26545240) Refractive error ( 32231278) Schizophrenia (inflammation and infection response interaction) ( 25781172) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		16 interacting genes: AKT1 BIN1 DLAT FGFR1 ITGB3 KAT2B LAMTOR5 PDHA1 PDK2 PIK3CA RPS6KB1 SGK1 UBE2O USP4 XRCC6 YWHAQ	38 interacting genes: ASPG BRAF CAMKK1 CARHSP1 CDKN1B CDKN2A CETN3 CREB1 FANCA FOXO3 GADD45G GSK3A GSK3B IKBKG KCNJ1 KPNA2 MAGEA1 MAL2 MAPK7 MAPKAP1 MLLT3 NDRG1 NDRG4 NEDD4 NEDD4L NEK6 NHERF2 PDK1 PDK2 PDPK1 PIK3CA PIN1 PPP2CA RABAC1 RICTOR SLC1A3 TMEM184C UBC
Entrez ID		5163	6446
HPRD ID		03954	04264
Ensembl ID		ENSG00000152256	ENSG00000118515
Uniprot IDs		B7Z207 B7Z7N6 Q15118	B7Z325 E9PR89 O00141
PDB IDs		2Q8F 2Q8G 2Q8H	2R5T 3HDM 3HDN 7PUE
Enriched GO Terms of Interacting Partners?		Glucose Metabolic Process Monosaccharide Metabolic Process Hexose Metabolic Process Positive Regulation Of TOR Signaling Insulin Receptor Signaling Pathway Pyruvate Dehydrogenase Complex Carbohydrate Metabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of TOR Signaling Positive Regulation Of TORC1 Signaling TORC1 Signaling Cellular Response To Hormone Stimulus Cellular Response To Peptide Hormone Stimulus TOR Signaling Intracellular Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Phosphatidylinositol-mediated Signaling Regulation Of TORC1 Signaling Cellular Response To Insulin Stimulus Protein Serine/threonine/tyrosine Kinase Activity Regulation Of Programmed Cell Death Tricarboxylic Acid Cycle Cellular Response To Nutrient Levels Insulin-like Growth Factor Receptor Signaling Pathway Protein-containing Complex Cellular Response To Nutrient Response To Peptide Hormone Cellular Response To Oxygen-containing Compound Transferase Activity Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Translational Initiation Response To Hormone Phosphate-containing Compound Metabolic Process Response To Insulin Kinase Activity Pyruvate Decarboxylation To Acetyl-CoA ATP Binding Regulation Of Apoptotic Process Small Molecule Metabolic Process Negative Regulation Of TORC1 Signaling Regulation Of Intracellular Signal Transduction Pyruvate Metabolic Process Regulation Of Biological Quality Organic Acid Metabolic Process Response To Ketone Anoikis Positive Regulation Of Intracellular Signal Transduction Response To Activity Positive Regulation Of Signal Transduction	Intracellular Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Cytosol Regulation Of Signal Transduction Intracellular Signaling Cassette Regulation Of Intracellular Signal Transduction Regulation Of Growth Cellular Response To Stress Positive Regulation Of Signal Transduction Kinase Activity Protein Serine Kinase Activity Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Protein Kinase Activity Regulation Of Programmed Cell Death Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Oxygen-containing Compound Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Serine/threonine Kinase Activity Tau Protein Binding Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity TORC2 Signaling Apoptotic Signaling Pathway Response To Metal Ion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Apoptotic Process Phosphothreonine Residue Binding Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Programmed Cell Death Regulation Of Cell Growth Regulation Of Glycogen (starch) Synthase Activity ATP Binding Regulation Of Phosphorus Metabolic Process Regulation Of Amide Metabolic Process Regulation Of Cellular Component Organization Negative Regulation Of Wnt Signaling Pathway Cytoplasm Cellular Response To Peptide Hormone Stimulus
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