HSPA1B and HSPBP1

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HSPA1B	HSPBP1
Gene Name		heat shock 70kDa protein 1B	HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Centriole Cytosol Focal Adhesion COP9 Signalosome Inclusion Body Aggresome Nuclear Speck Ribonucleoprotein Complex Vesicle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Virus Receptor Activity G-protein Coupled Receptor Binding Double-stranded RNA Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding ATPase Activity, Coupled Protein Binding Involved In Protein Folding Poly(A) RNA Binding Protein N-terminus Binding Unfolded Protein Binding	Enzyme Inhibitor Activity Protein Binding
	Biological Process	MRNA Catabolic Process Response To Unfolded Protein Negative Regulation Of Cell Proliferation Response To Virus Gene Expression Regulation Of Cell Death Negative Regulation Of Cell Growth Negative Regulation Of Protein Ubiquitination Cellular Response To Oxidative Stress Cellular Response To Heat Protein Refolding Negative Regulation Of Apoptotic Process Positive Regulation Of Erythrocyte Differentiation Protein Stabilization Negative Regulation Of Cell Death Cellular Heat Acclimation Negative Regulation Of Inclusion Body Assembly Regulation Of Cellular Response To Heat Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Protein Folding Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Catalytic Activity
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements Viral RNP Complexes in the Host Cell Nucleus Attenuation phase Regulation of HSF1-mediated heat shock response Cellular response to heat stress AUF1 (hnRNP D0) destabilizes mRNA Influenza Infection Influenza Life Cycle HSF1-dependent transactivation Export of Viral Ribonucleoproteins from Nucleus
Drugs		Adenosine-5\'-Diphosphate
Diseases
GWAS
Protein-Protein Interactions		10 interactors: AIFM1 BAG1 DNMBP HSPBP1 PGAM5 STUB1 SUMO4 TGM2 YWHAB YWHAZ	10 interactors: APP HSPA1A HSPA1B HSPA2 HSPA4 HSPA5 HSPA8 HSPA9 LRIF1 NOTCH2NL
Entrez ID		3304	23640
HPRD ID		06784	09991
Ensembl ID		ENSG00000204388	ENSG00000133265
Uniprot IDs		A8K5I0 P08107	Q9NZL4
PDB IDs		1HJO 1S3X 1XQS 2E88 2E8A 2LMG 3A8Y 3ATU 3ATV 3AY9 3D2E 3D2F 3JXU 3LOF 4J8F	1XQR 1XQS
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Programmed Cell Death Cell Death Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Regulation Of Cell Death Positive Regulation Of Proteolysis Positive Regulation Of Mitochondrion Organization Apoptotic Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Mitochondrion Positive Regulation Of Proteasomal Protein Catabolic Process Apoptotic Process Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Mitochondrion Organization Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Chaperone-mediated Protein Complex Assembly Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Motor Neuron Apoptotic Process Positive Regulation Of Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Signal Transduction Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Golgi Reassembly Positive Regulation Of Cellular Protein Catabolic Process Response To Endoplasmic Reticulum Stress Regulation Of Proteolysis Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Dephosphorylation Histamine Secretion By Mast Cell Chaperone Cofactor-dependent Protein Refolding Salivary Gland Cavitation Signaling Cell Communication Establishment Of Golgi Localization Ubiquitin-dependent SMAD Protein Catabolic Process Cellular Metabolic Process Regulation Of Proteasomal Protein Catabolic Process	Response To Unfolded Protein Protein Refolding Negative Regulation Of Inclusion Body Assembly Regulation Of Inclusion Body Assembly Protein Folding Regulation Of Cellular Response To Heat Cellular Heat Acclimation Cellular Response To Heat Response To Heat Positive Regulation Of Erythrocyte Differentiation MRNA Metabolic Process Response To Temperature Stimulus Regulation Of Protein Ubiquitination Regulation Of Erythrocyte Differentiation Response To Stress Viral Entry Into Host Cell Entry Into Host Cell Response To Organic Substance Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Protein Targeting To Mitochondrion Negative Regulation Of Apoptotic Process Platelet Degranulation Negative Regulation Of Programmed Cell Death Protein Localization To Mitochondrion Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G2/M Transition Of Mitotic Cell Cycle Synaptonemal Complex Disassembly Negative Regulation Of Fibril Organization Regulation Of Protein Folding In Endoplasmic Reticulum Positive Regulation Of Myeloid Cell Differentiation Response To External Stimulus Cellular Protein Metabolic Process Negative Regulation Of Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Response To Oxidative Stress Protein Stabilization Regulation Of Cellular Protein Metabolic Process Response To Abiotic Stimulus Establishment Of Localization In Cell Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Protein Ubiquitination Interaction With Host Cerebellum Structural Organization Synaptic Growth At Neuromuscular Junction Secretion By Cell Protein Localization To Organelle Regulation Of Protein Metabolic Process Locomotion Collateral Sprouting In Absence Of Injury Regulation Of Fibril Organization Viral Process
Tagcloud ?		alphascreen ammp calnexin cndp2 combines hsp90b1 hspa5 hspa9 identifier imbalance itraq nfhcc nonfibrotic nontumor p4hb pdia6 phosphoproteomics pointed proteomexchange proteomics proteostasis pxd001253 resident ser583 txn ubc unraveling vcp	accelerating associates bag biogenesis cftr cochaperone compartments conductance cystic deltaf508 export fibrosis folding hsc70 hsp105 hsp105alpha impairing inform interferes misfolded misfolding multilevel opportunities phe potently relates serves stabilizes super
Tagcloud (Difference) ?		alphascreen ammp calnexin cndp2 combines hsp90b1 hspa5 hspa9 identifier imbalance itraq nfhcc nonfibrotic nontumor p4hb pdia6 phosphoproteomics pointed proteomexchange proteomics proteostasis pxd001253 resident ser583 txn ubc unraveling vcp	accelerating associates bag biogenesis cftr cochaperone compartments conductance cystic deltaf508 export fibrosis folding hsc70 hsp105 hsp105alpha impairing inform interferes misfolded misfolding multilevel opportunities phe potently relates serves stabilizes super
Tagcloud (Intersection) ?