HSPA1B and AIFM1

Number of citations of the paper that reports this interaction (PMID 11533664)
118

Data Source:
HPRD (in vivo, in vitro)

		HSPA1B	AIFM1
Gene Name		heat shock 70kDa protein 1B	apoptosis-inducing factor, mitochondrion-associated, 1
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Centriole Cytosol Focal Adhesion COP9 Signalosome Inclusion Body Aggresome Nuclear Speck Ribonucleoprotein Complex Vesicle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Blood Microparticle	Nucleus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Virus Receptor Activity G-protein Coupled Receptor Binding Double-stranded RNA Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding ATPase Activity, Coupled Protein Binding Involved In Protein Folding Poly(A) RNA Binding Protein N-terminus Binding Unfolded Protein Binding	DNA Binding Protein Binding Electron Carrier Activity NAD(P)H Oxidase Activity Oxidoreductase Activity, Acting On NAD(P)H Protein Dimerization Activity FAD Binding
	Biological Process	MRNA Catabolic Process Response To Unfolded Protein Negative Regulation Of Cell Proliferation Response To Virus Gene Expression Regulation Of Cell Death Negative Regulation Of Cell Growth Negative Regulation Of Protein Ubiquitination Cellular Response To Oxidative Stress Cellular Response To Heat Protein Refolding Negative Regulation Of Apoptotic Process Positive Regulation Of Erythrocyte Differentiation Protein Stabilization Negative Regulation Of Cell Death Cellular Heat Acclimation Negative Regulation Of Inclusion Body Assembly Regulation Of Cellular Response To Heat Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	DNA Catabolic Process Apoptotic DNA Fragmentation Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Neuron Differentiation Chromosome Condensation Mitochondrial Respiratory Chain Complex I Assembly Positive Regulation Of Apoptotic Process Cell Redox Homeostasis Neuron Apoptotic Process Oxidation-reduction Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Apoptotic DNA Fragmentation
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements Viral RNP Complexes in the Host Cell Nucleus Attenuation phase Regulation of HSF1-mediated heat shock response Cellular response to heat stress AUF1 (hnRNP D0) destabilizes mRNA Influenza Infection Influenza Life Cycle HSF1-dependent transactivation Export of Viral Ribonucleoproteins from Nucleus
Drugs		Adenosine-5\'-Diphosphate	Flavin-Adenine Dinucleotide
Diseases
GWAS
Protein-Protein Interactions		10 interactors: AIFM1 BAG1 DNMBP HSPBP1 PGAM5 STUB1 SUMO4 TGM2 YWHAB YWHAZ	11 interactors: CASP3 EIF3G HSPA1A HSPA1B MLH1 NOA1 SETDB1 STC2 TSC22D4 WWC1 XIAP
Entrez ID		3304	9131
HPRD ID		06784	02161
Ensembl ID		ENSG00000204388	ENSG00000156709
Uniprot IDs		A8K5I0 P08107	O95831
PDB IDs		1HJO 1S3X 1XQS 2E88 2E8A 2LMG 3A8Y 3ATU 3ATV 3AY9 3D2E 3D2F 3JXU 3LOF 4J8F	1M6I 4FDC 4LII
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Programmed Cell Death Cell Death Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Regulation Of Cell Death Positive Regulation Of Proteolysis Positive Regulation Of Mitochondrion Organization Apoptotic Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Mitochondrion Positive Regulation Of Proteasomal Protein Catabolic Process Apoptotic Process Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Mitochondrion Organization Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Chaperone-mediated Protein Complex Assembly Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Motor Neuron Apoptotic Process Positive Regulation Of Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Signal Transduction Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Golgi Reassembly Positive Regulation Of Cellular Protein Catabolic Process Response To Endoplasmic Reticulum Stress Regulation Of Proteolysis Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Dephosphorylation Histamine Secretion By Mast Cell Chaperone Cofactor-dependent Protein Refolding Salivary Gland Cavitation Signaling Cell Communication Establishment Of Golgi Localization Ubiquitin-dependent SMAD Protein Catabolic Process Cellular Metabolic Process Regulation Of Proteasomal Protein Catabolic Process	Negative Regulation Of Cellular Metabolic Process Cellular Heat Acclimation Negative Regulation Of Growth Regulation Of Metabolic Process Negative Regulation Of Inclusion Body Assembly Gene Expression Cellular Response To Stress Response To Unfolded Protein Response To Oxidative Stress Regulation Of Inclusion Body Assembly Aromatic Compound Catabolic Process Protein Refolding Positive Regulation Of Erythrocyte Differentiation MRNA Catabolic Process RNA Catabolic Process Response To Abiotic Stimulus Intrinsic Apoptotic Signaling Pathway Hippo Signaling Regulation Of Cellular Response To Heat Cellular Response To Oxidative Stress Regulation Of Protein Ubiquitination Regulation Of Growth Regulation Of Erythrocyte Differentiation Viral Entry Into Host Cell Entry Into Host Cell Response To Stress Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cell Death Cellular Response To Heat Cellular Macromolecule Catabolic Process Apoptotic Signaling Pathway Meiotic Spindle Midzone Assembly Meiotic Metaphase I Plate Congression Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Process Negative Regulation Of Apoptotic Process Positive Regulation Of Myeloid Cell Differentiation Negative Regulation Of Programmed Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apoptotic Process Negative Regulation Of Developmental Growth Negative Regulation Of Cell Death Protein Stabilization Programmed Cell Death Positive Regulation Of Protein Linear Polyubiquitination Negative Regulation Of Mitotic Recombination Cell Death Death Negative Regulation Of Protein Ubiquitination
Tagcloud ?		alphascreen ammp calnexin cndp2 combines hsp90b1 hspa5 hspa9 identifier imbalance itraq nfhcc nonfibrotic nontumor p4hb pdia6 phosphoproteomics pointed proteomexchange proteomics proteostasis pxd001253 resident ser583 txn ubc unraveling vcp	agilent antiproliferative biologically cables2 ccnk cdc25b cdca3 cdca8 cnnm3 constituents cytometric dmso emge ginseng ginsenosides hepatocarcinoma hepg2 hspa9 ic50 metabolized mu panax ppt primeview rg3 rh1 saponin saponins uqcrc2
Tagcloud (Difference) ?		alphascreen ammp calnexin cndp2 combines hsp90b1 hspa5 identifier imbalance itraq nfhcc nonfibrotic nontumor p4hb pdia6 phosphoproteomics pointed proteomexchange proteomics proteostasis pxd001253 resident ser583 txn ubc unraveling vcp	agilent antiproliferative biologically cables2 ccnk cdc25b cdca3 cdca8 cnnm3 constituents cytometric dmso emge ginseng ginsenosides hepatocarcinoma hepg2 ic50 metabolized mu panax ppt primeview rg3 rh1 saponin saponins uqcrc2
Tagcloud (Intersection) ?		hspa9