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HSPA1B and AIFM1
Number of citations of the paper that reports this interaction (PubMedID
11533664
)
0
Data Source:
HPRD
(in vivo, in vitro)
HSPA1B
AIFM1
Description
heat shock protein family A (Hsp70) member 1B
apoptosis inducing factor mitochondria associated 1
Image
GO Annotations
Cellular Component
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Centrosome
Centriole
Cytosol
Cytoskeleton
Plasma Membrane
Focal Adhesion
Inclusion Body
Aggresome
Nuclear Speck
Vesicle
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Blood Microparticle
Ficolin-1-rich Granule Lumen
Ribonucleoprotein Complex
Nucleus
Cytoplasm
Mitochondrion
Mitochondrial Inner Membrane
Mitochondrial Intermembrane Space
Cytosol
Membrane
Perinuclear Region Of Cytoplasm
Molecular Function
Nucleotide Binding
Virus Receptor Activity
G Protein-coupled Receptor Binding
RNA Binding
Signaling Receptor Binding
Protein Binding
ATP Binding
ATP Hydrolysis Activity
Enzyme Binding
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Histone Deacetylase Binding
Protein Folding Chaperone
Unfolded Protein Binding
C3HC4-type RING Finger Domain Binding
ATP-dependent Protein Disaggregase Activity
ATP-dependent Protein Folding Chaperone
DNA Binding
NADH Dehydrogenase Activity
Protein Binding
NAD(P)H Oxidase H2O2-forming Activity
Oxidoreductase Activity
Oxidoreductase Activity, Acting On NAD(P)H
Protein Dimerization Activity
FAD Binding
Poly-ADP-D-ribose Binding
Biological Process
MRNA Catabolic Process
Protein Folding
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Negative Regulation Of Cell Growth
Regulation Of Protein Ubiquitination
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Interleukin-8 Production
Cellular Response To Oxidative Stress
Cellular Response To Heat
Protein Refolding
Negative Regulation Of Apoptotic Process
Positive Regulation Of Erythrocyte Differentiation
ATP Metabolic Process
Symbiont Entry Into Host Cell
Protein Stabilization
Positive Regulation Of NF-kappaB Transcription Factor Activity
Cellular Heat Acclimation
Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Cellular Response To Steroid Hormone Stimulus
Positive Regulation Of Microtubule Nucleation
Negative Regulation Of Inclusion Body Assembly
Regulation Of Mitotic Spindle Assembly
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Response To Ischemia
Apoptotic Process
Response To Toxic Substance
Neuron Differentiation
Mitochondrial Respiratory Chain Complex Assembly
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Neuron Apoptotic Process
Protein Import Into Mitochondrial Intermembrane Space
Positive Regulation Of Necroptotic Process
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Cellular Response To Hydrogen Peroxide
Cellular Response To Estradiol Stimulus
Cellular Response To Hypoxia
Cellular Response To Nitric Oxide
Mitochondrial Disulfide Relay System
Response To L-glutamate
Cellular Response To Aldosterone
Pathways
Viral RNP Complexes in the Host Cell Nucleus
Regulation of HSF1-mediated heat shock response
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
Attenuation phase
HSF1-dependent transactivation
AUF1 (hnRNP D0) binds and destabilizes mRNA
Neutrophil degranulation
PKR-mediated signaling
Mitochondrial unfolded protein response (UPRmt)
Regulation of HSF1-mediated heat shock response
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
Attenuation phase
HSF1-dependent transactivation
Neutrophil degranulation
PKR-mediated signaling
Mitochondrial unfolded protein response (UPRmt)
Drugs
Flavin adenine dinucleotide
MCC
Diseases
Combined oxidative phosphorylation deficiency (COXPD)
GWAS
Asthma (
31619474
)
Asthma (childhood onset) (
31619474
)
Asthma and major depressive disorder (
31619474
)
Autism spectrum disorder or schizophrenia (
28540026
)
Eosinophilic esophagitis (
29904099
)
Inflammatory bowel disease (
28067908
)
Systemic lupus erythematosus (
32771030
)
Ulcerative colitis (
28067908
)
Bipolar disorder (
31043756
)
Interacting Genes
25 interacting genes:
AIFM1
BAG1
BAG4
BNIP2
CEBPA
DNMBP
F2RL1
FAF1
FTCD
HSPBP1
MYBPC2
NEDD8
PGAM5
SGCG
SNCA
ST13
STUB1
SUMO4
TGM2
TOMM70
TRIM38
TTN
UBQLN2
YWHAB
YWHAZ
11 interacting genes:
CASP3
EIF3G
HSPA1A
HSPA1B
MLH1
NOA1
SETDB1
STC2
TSC22D4
WWC1
XIAP
Entrez ID
3304
9131
HPRD ID
06784
02161
Ensembl ID
ENSG00000204388
ENSG00000156709
Uniprot IDs
A8K5I0
P0DMV8
P0DMV9
E9PMA0
O95831
PDB IDs
1HJO
1S3X
1XQS
2E88
2E8A
2LMG
3A8Y
3ATU
3ATV
3AY9
3D2E
3D2F
3JXU
3LOF
3Q49
4IO8
4J8F
4PO2
4WV5
4WV7
5AQW
5AQX
5AQY
5AQZ
5AR0
5BN8
5BN9
5BPL
5BPM
5BPN
5GJJ
5MKR
5MKS
5XI9
5XIR
6FDT
6FHK
6G3R
6G3S
6JPV
6K39
6ZYI
7F4X
7F4Z
7F50
7FGM
7GY4
7GY5
7GY6
7GY7
7GY8
7GY9
7GYA
7GYB
7GYC
7GYD
7GYE
7GYF
7GYG
7GYH
7GYI
7GYJ
7GYK
7GYL
7GYM
7GYN
7GYO
7GYP
7GYQ
7GYR
7GYS
7GYT
7GYU
7GYV
7GYW
7GYX
7KW7
7Q4R
1M6I
4BUR
4BV6
4FDC
4LII
5FMH
5FS6
5FS7
5FS8
5FS9
5KVH
5KVI
8D3E
8D3G
8D3H
8D3I
8D3J
8D3K
8D3N
8D3O
8VGY
Enriched GO Terms of Interacting Partners
?
Ubiquitin Protein Ligase Binding
Adenyl-nucleotide Exchange Factor Activity
Regulation Of Programmed Cell Death
Positive Regulation Of Programmed Cell Death
Protein Folding
Regulation Of Protein Catabolic Process
Positive Regulation Of Protein Catabolic Process
Regulation Of Apoptotic Process
Protein Domain Specific Binding
Positive Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Protein Localization
Phosphoserine Residue Binding
Cytosol
Protein Sequestering Activity
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Hsp70 Protein Binding
Positive Regulation Of Apoptotic Process
Regulation Of Signal Transduction
Positive Regulation Of Catabolic Process
Positive Regulation Of Small GTPase Mediated Signal Transduction
Regulation Of Protein Stability
Positive Regulation Of Proteolysis
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Proteolysis
Protein Tag Activity
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Kinase Regulator Activity
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Smooth Muscle Cell Apoptotic Process
Response To Alkaloid
Positive Regulation Of ERAD Pathway
Response To Endoplasmic Reticulum Stress
ERAD Pathway
Regulation Of Cell Communication
Regulation Of Signaling
Dopamine Transport
Perinuclear Region Of Cytoplasm
Protein-folding Chaperone Binding
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
M Band
Regulation Of ERAD Pathway
Negative Regulation Of Apoptotic Process
Regulation Of Smooth Muscle Cell Apoptotic Process
Regulation Of Small GTPase Mediated Signal Transduction
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Defense Response
Cellular Response To Stress
RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding
Regulation Of Establishment Of Protein Localization
Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium
Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Gene Expression
C3HC4-type RING Finger Domain Binding
ATP-dependent Protein Disaggregase Activity
Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Cellular Heat Acclimation
Negative Regulation Of Metabolic Process
Negative Regulation Of Growth
Positive Regulation Of Microtubule Nucleation
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Negative Regulation Of Inclusion Body Assembly
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Inclusion Body
Perinuclear Region Of Cytoplasm
Regulation Of Microtubule Nucleation
Response To Oxidative Stress
MRNA Catabolic Process
Regulation Of Inclusion Body Assembly
Regulation Of Mitotic Spindle Assembly
Response To Lipid
Execution Phase Of Apoptosis
Enzyme Binding
Protein Refolding
Positive Regulation Of Defense Response
Regulation Of Cytokine-mediated Signaling Pathway
Positive Regulation Of Erythrocyte Differentiation
Aggresome
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
ATP-dependent Protein Folding Chaperone
Positive Regulation Of Microtubule Polymerization
Regulation Of Spindle Assembly
Regulation Of Protein Ubiquitination
RNA Catabolic Process
Cellular Response To Stress
Regulation Of Mitotic Spindle Organization
Response To Steroid Hormone
Macromolecule Catabolic Process
Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Regulation Of Erythrocyte Differentiation
Regulation Of Post-translational Protein Modification
Cellular Response To Heat
Regulation Of Growth
Intracellular Signal Transduction
Response To Hormone
Late Recombination Nodule
Meiotic Metaphase I Homologous Chromosome Alignment
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