HSPA1B and BAG1

Number of citations of the paper that reports this interaction (PMID 11231577)
54

Data Source:
HPRD (two hybrid, in vitro)

		HSPA1B	BAG1
Gene Name		heat shock 70kDa protein 1B	BCL2-associated athanogene
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Centriole Cytosol Focal Adhesion COP9 Signalosome Inclusion Body Aggresome Nuclear Speck Ribonucleoprotein Complex Vesicle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Blood Microparticle	Nucleus Cytoplasm
	Molecular Function	Virus Receptor Activity G-protein Coupled Receptor Binding Double-stranded RNA Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding ATPase Activity, Coupled Protein Binding Involved In Protein Folding Poly(A) RNA Binding Protein N-terminus Binding Unfolded Protein Binding	Receptor Signaling Protein Activity Protein Binding Chaperone Binding
	Biological Process	MRNA Catabolic Process Response To Unfolded Protein Negative Regulation Of Cell Proliferation Response To Virus Gene Expression Regulation Of Cell Death Negative Regulation Of Cell Growth Negative Regulation Of Protein Ubiquitination Cellular Response To Oxidative Stress Cellular Response To Heat Protein Refolding Negative Regulation Of Apoptotic Process Positive Regulation Of Erythrocyte Differentiation Protein Stabilization Negative Regulation Of Cell Death Cellular Heat Acclimation Negative Regulation Of Inclusion Body Assembly Regulation Of Cellular Response To Heat Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Apoptotic Process Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Chaperone Cofactor-dependent Protein Refolding
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements Viral RNP Complexes in the Host Cell Nucleus Attenuation phase Regulation of HSF1-mediated heat shock response Cellular response to heat stress AUF1 (hnRNP D0) destabilizes mRNA Influenza Infection Influenza Life Cycle HSF1-dependent transactivation Export of Viral Ribonucleoproteins from Nucleus
Drugs		Adenosine-5\'-Diphosphate
Diseases
GWAS
Protein-Protein Interactions		10 interactors: AIFM1 BAG1 DNMBP HSPBP1 PGAM5 STUB1 SUMO4 TGM2 YWHAB YWHAZ	26 interactors: AR ARRB1 BCL2 BCL2L1 ESR1 HBEGF HSPA1A HSPA1B HSPA4 HSPA8 MAPT MET NR3C1 PDGFRB PPP1R15A PSMD1 PSMD2 PYGL RAF1 RARA RB1 SIAH1 STUB1 TRIM23 TRIM27 VDR
Entrez ID		3304	573
HPRD ID		06784	03292
Ensembl ID		ENSG00000204388	ENSG00000107262
Uniprot IDs		A8K5I0 P08107	Q99933
PDB IDs		1HJO 1S3X 1XQS 2E88 2E8A 2LMG 3A8Y 3ATU 3ATV 3AY9 3D2E 3D2F 3JXU 3LOF 4J8F	1HX1 1WXV 3FZF 3FZH 3FZK 3FZL 3FZM 3LDQ 3M3Z
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Programmed Cell Death Cell Death Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Regulation Of Cell Death Positive Regulation Of Proteolysis Positive Regulation Of Mitochondrion Organization Apoptotic Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Mitochondrion Positive Regulation Of Proteasomal Protein Catabolic Process Apoptotic Process Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Mitochondrion Organization Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Chaperone-mediated Protein Complex Assembly Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Motor Neuron Apoptotic Process Positive Regulation Of Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Signal Transduction Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Golgi Reassembly Positive Regulation Of Cellular Protein Catabolic Process Response To Endoplasmic Reticulum Stress Regulation Of Proteolysis Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Dephosphorylation Histamine Secretion By Mast Cell Chaperone Cofactor-dependent Protein Refolding Salivary Gland Cavitation Signaling Cell Communication Establishment Of Golgi Localization Ubiquitin-dependent SMAD Protein Catabolic Process Cellular Metabolic Process Regulation Of Proteasomal Protein Catabolic Process	Regulation Of Cell Death Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Negative Regulation Of Signaling Regulation Of Signaling Intracellular Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Regulation Of Metabolic Process Programmed Cell Death Cell Death Death Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Response To Stimulus Regulation Of Cellular Component Organization Apoptotic Process Positive Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Unfolded Protein Negative Regulation Of Cellular Protein Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Cell Proliferation Signaling Positive Regulation Of Catalytic Activity Cell Communication Gland Development Anatomical Structure Morphogenesis Regulation Of Cellular Ketone Metabolic Process Signal Transduction Steroid Hormone Mediated Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Protein Ubiquitination Viral Process Negative Regulation Of Protein Ubiquitination Positive Regulation Of Intracellular Signal Transduction Protein Ubiquitination Response To External Stimulus Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Amino Acid Metabolic Process Cellular Response To Organic Substance
Tagcloud ?		alphascreen ammp calnexin cndp2 combines hsp90b1 hspa5 hspa9 identifier imbalance itraq nfhcc nonfibrotic nontumor p4hb pdia6 phosphoproteomics pointed proteomexchange proteomics proteostasis pxd001253 resident ser583 txn ubc unraveling vcp	bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2
Tagcloud (Difference) ?		alphascreen ammp calnexin cndp2 combines hsp90b1 hspa5 hspa9 identifier imbalance itraq nfhcc nonfibrotic nontumor p4hb pdia6 phosphoproteomics pointed proteomexchange proteomics proteostasis pxd001253 resident ser583 txn ubc unraveling vcp	bcl2l2 bctis ccna2 comprehend ctsb deregulations fgf1 fosl1 gabrp gsn hnepi id2 il6r itgb4 klf5 klk5 map2k7 microdissected ngfb ngfr ontological pappa plau scgb1d2 scgb2a1 serpinb5 serpine1 thbs1 thbs2
Tagcloud (Intersection) ?