HSPA1B and PGAM5

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HSPA1B	PGAM5
Gene Name		heat shock 70kDa protein 1B	phosphoglycerate mutase family member 5
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Centriole Cytosol Focal Adhesion COP9 Signalosome Inclusion Body Aggresome Nuclear Speck Ribonucleoprotein Complex Vesicle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Blood Microparticle	Mitochondrion Mitochondrial Outer Membrane Integral Component Of Membrane
	Molecular Function	Virus Receptor Activity G-protein Coupled Receptor Binding Double-stranded RNA Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding ATPase Activity, Coupled Protein Binding Involved In Protein Folding Poly(A) RNA Binding Protein N-terminus Binding Unfolded Protein Binding	Phosphoprotein Phosphatase Activity GTPase Activator Activity Phosphatase Activity Protein Complex Binding
	Biological Process	MRNA Catabolic Process Response To Unfolded Protein Negative Regulation Of Cell Proliferation Response To Virus Gene Expression Regulation Of Cell Death Negative Regulation Of Cell Growth Negative Regulation Of Protein Ubiquitination Cellular Response To Oxidative Stress Cellular Response To Heat Protein Refolding Negative Regulation Of Apoptotic Process Positive Regulation Of Erythrocyte Differentiation Protein Stabilization Negative Regulation Of Cell Death Cellular Heat Acclimation Negative Regulation Of Inclusion Body Assembly Regulation Of Cellular Response To Heat Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Dephosphorylation Positive Regulation Of GTPase Activity Necroptotic Process
Pathways		Regulation of mRNA stability by proteins that bind AU-rich elements Viral RNP Complexes in the Host Cell Nucleus Attenuation phase Regulation of HSF1-mediated heat shock response Cellular response to heat stress AUF1 (hnRNP D0) destabilizes mRNA Influenza Infection Influenza Life Cycle HSF1-dependent transactivation Export of Viral Ribonucleoproteins from Nucleus
Drugs		Adenosine-5\'-Diphosphate
Diseases
GWAS
Protein-Protein Interactions		10 interactors: AIFM1 BAG1 DNMBP HSPBP1 PGAM5 STUB1 SUMO4 TGM2 YWHAB YWHAZ	5 interactors: HSPA1B PINK1 SETDB1 YWHAG ZBTB16
Entrez ID		3304	192111
HPRD ID		06784	14681
Ensembl ID		ENSG00000204388	ENSG00000247077
Uniprot IDs		A8K5I0 P08107	Q96HS1
PDB IDs		1HJO 1S3X 1XQS 2E88 2E8A 2LMG 3A8Y 3ATU 3ATV 3AY9 3D2E 3D2F 3JXU 3LOF 4J8F	3MXO 3O0T
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Programmed Cell Death Cell Death Death Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Catalytic Activity Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Regulation Of Cell Death Positive Regulation Of Proteolysis Positive Regulation Of Mitochondrion Organization Apoptotic Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Mitochondrion Positive Regulation Of Proteasomal Protein Catabolic Process Apoptotic Process Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Mitochondrion Organization Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Chaperone-mediated Protein Complex Assembly Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Motor Neuron Apoptotic Process Positive Regulation Of Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Signal Transduction Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Golgi Reassembly Positive Regulation Of Cellular Protein Catabolic Process Response To Endoplasmic Reticulum Stress Regulation Of Proteolysis Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Dephosphorylation Histamine Secretion By Mast Cell Chaperone Cofactor-dependent Protein Refolding Salivary Gland Cavitation Signaling Cell Communication Establishment Of Golgi Localization Ubiquitin-dependent SMAD Protein Catabolic Process Cellular Metabolic Process Regulation Of Proteasomal Protein Catabolic Process	Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Mitochondrion Organization Regulation Of Apoptotic Process Regulation Of Cell Death Protein Stabilization Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Mitochondrion Organization Positive Regulation Of Cell Death Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Stability Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Cellular Response To Hypoxia Cellular Heat Acclimation Positive Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Regulation Of Myeloid Cell Differentiation Positive Regulation Of Apoptotic Signaling Pathway Cellular Response To Oxidative Stress Regulation Of Protein Ubiquitination Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Cellular Respiration Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Regulation Of Cellular Response To Hypoxia Positive Regulation Of NK T Cell Differentiation Negative Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Dopamine Secretion Male Germ-line Stem Cell Asymmetric Division Peptidyl-serine Autophosphorylation Negative Regulation Of Gene Expression Regulation Of Synaptic Transmission Negative Regulation Of Oxidative Stress-induced Neuron Death TORC2 Signaling Positive Regulation Of Mitochondrial Fission Histone H3-K9 Trimethylation Positive Regulation Of Synaptic Transmission, Dopaminergic Regulation Of Oxidative Phosphorylation Negative Regulation Of Inclusion Body Assembly Regulation Of Mitochondrion Degradation Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Catecholamine Secretion Negative Regulation Of Hydrogen Peroxide-induced Cell Death Regulation Of Mitochondrial Fission Regulation Of Cellular Respiration Regulation Of Cell Differentiation Negative Regulation Of Phosphorylation Regulation Of Hydrogen Peroxide-induced Cell Death Positive Regulation Of Organelle Organization Response To Oxidative Stress Regulation Of Metabolic Process
Tagcloud ?		alphascreen ammp calnexin cndp2 combines hsp90b1 hspa5 hspa9 identifier imbalance itraq nfhcc nonfibrotic nontumor p4hb pdia6 phosphoproteomics pointed proteomexchange proteomics proteostasis pxd001253 resident ser583 txn ubc unraveling vcp	activates advances atg atg11 atg32 atg8 bnip3 bnip3l casein catabolic ck2 classic damaged dephosphorylates fccp fundc1 homolog lc3 mammalian mammals mitochondria mitophagy nix notably phosphorylate phosphorylates reversible unwanted yeast
Tagcloud (Difference) ?		alphascreen ammp calnexin cndp2 combines hsp90b1 hspa5 hspa9 identifier imbalance itraq nfhcc nonfibrotic nontumor p4hb pdia6 phosphoproteomics pointed proteomexchange proteomics proteostasis pxd001253 resident ser583 txn ubc unraveling vcp	activates advances atg atg11 atg32 atg8 bnip3 bnip3l casein catabolic ck2 classic damaged dephosphorylates fccp fundc1 homolog lc3 mammalian mammals mitochondria mitophagy nix notably phosphorylate phosphorylates reversible unwanted yeast
Tagcloud (Intersection) ?