RASGRF2 and KRAS

Number of citations of the paper that reports this interaction (PMID 11238945)
3

Data Source:
BioGRID (pull down)

		RASGRF2	KRAS
Gene Name		Ras protein-specific guanine nucleotide-releasing factor 2	Kirsten rat sarcoma viral oncogene homolog
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Cytosol Plasma Membrane	Cytoplasm Mitochondrion Cytosol Plasma Membrane Focal Adhesion Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Membrane Raft
	Molecular Function	Rho Guanyl-nucleotide Exchange Factor Activity Calmodulin Binding	Protein Binding GTP Binding GMP Binding GDP Binding LRR Domain Binding Protein Complex Binding
	Biological Process	Small GTPase Mediated Signal Transduction Synaptic Transmission Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity	MAPK Cascade Activation Of MAPKK Activity Positive Regulation Of Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Axon Guidance Blood Coagulation Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Visual Learning Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Actin Cytoskeleton Organization Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Rac Protein Signal Transduction Social Behavior Fc-epsilon Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Negative Regulation Of Cell Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Regulation Of Long-term Neuronal Synaptic Plasticity Leukocyte Migration Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Striated Muscle Cell Differentiation Response To Glucocorticoid Response To Mineralocorticoid Epithelial Tube Branching Involved In Lung Morphogenesis
Pathways		Signaling by GPCR Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling CREB phosphorylation through the activation of Ras Rho GTPase cycle GPCR downstream signaling Activation of NMDA receptor upon glutamate binding and postsynaptic events NRAGE signals death through JNK Signaling by Rho GTPases G alpha (12/13) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses Post NMDA receptor activation events Ras activation uopn Ca2+ infux through NMDA receptor	Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease SHC-mediated cascade MEK activation FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer SHC1 events in ERBB2 signaling Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Gastrin-CREB signalling pathway via PKC and MAPK p38MAPK events SOS-mediated signalling SHC-mediated signalling Signaling by PDGF DAP12 interactions SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Signaling by VEGF Downstream signal transduction Signalling to RAS Signaling by FGFR mutants Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling Frs2-mediated activation Signaling by Leptin Adaptive Immune System Signalling to ERKs Prolonged ERK activation events Axon guidance IRS-mediated signalling IGF1R signaling cascade VEGFA-VEGFR2 Pathway IRS-related events triggered by IGF1R EGFR Transactivation by Gastrin GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation RAF phosphorylates MEK Downstream signaling of activated FGFR NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling SHC-mediated signalling Cytokine Signaling in Immune system IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer SHC-related events NGF signalling via TRKA from the plasma membrane Tie2 Signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Cell surface interactions at the vascular wall Signaling by FGFR ARMS-mediated activation RAF activation SHC1 events in EGFR signaling IRS-mediated signalling Activation of RAS in B cells FRS2-mediated cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Constitutive Signaling by EGFRvIII
Drugs
Diseases
GWAS		Eating disorders ( 23568457) Eating disorders (purging via substances) ( 23568457) Orofacial clefts ( 22419666)
Protein-Protein Interactions		1 interactors: KRAS	35 interactors: ADH6 APP ARAF BCL2 CALM1 CCT7 DDX47 DDX50 DNAJA3 EEF1A1 EGLN1 EPB42 FNTA FNTB HNRNPC IGSF21 LPAR1 MDFI PDE4DIP PGGT1B PIK3CA PIK3CG PIK3R2 PSMA3 RAF1 RALGDS RAP1GDS1 RASGRF2 RASGRP2 RASSF2 RASSF5 RBPMS RGL2 SHOC2 ZDHHC17
Entrez ID		5924	3845
HPRD ID		07588	01817
Ensembl ID		ENSG00000113319	ENSG00000133703
Uniprot IDs		O14827 Q68DX5	L7RSL8 P01116
PDB IDs			1D8D 1D8E 1KZO 1KZP 3GFT 4DSN 4DSO 4EPR 4EPT 4EPV 4EPW 4EPX 4EPY
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Rac Protein Signal Transduction Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Monooxygenase Activity Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synaptic Transmission, GABAergic Regulation Of Rac Protein Signal Transduction Regulation Of Nitric-oxide Synthase Activity Response To Mineralocorticoid Positive Regulation Of Oxidoreductase Activity Social Behavior Epithelial Tube Branching Involved In Lung Morphogenesis Positive Regulation Of Ras Protein Signal Transduction Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Small GTPase Mediated Signal Transduction Visual Learning Visual Behavior Activation Of MAPKK Activity Lung Morphogenesis Regulation Of Oxidoreductase Activity Associative Learning Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Learning Insulin Receptor Signaling Pathway Response To Glucocorticoid Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Synaptic Plasticity Response To Corticosteroid Negative Regulation Of Neuron Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Neuron Death Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of MAP Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Ras Protein Signal Transduction Neurotrophin Signaling Pathway Leukocyte Migration Fc-epsilon Receptor Signaling Pathway MAPK Cascade Striated Muscle Cell Differentiation Regulation Of Neuron Apoptotic Process Morphogenesis Of A Branching Epithelium Lung Development Morphogenesis Of A Branching Structure Respiratory Tube Development	Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Intracellular Signal Transduction Cellular Response To Stimulus Signal Transduction Regulation Of Phosphorus Metabolic Process Signaling Regulation Of Metabolic Process Cellular Response To Growth Factor Stimulus Cell Communication Response To Stimulus Regulation Of Phosphorylation Response To Growth Factor Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Platelet Activation Response To Wounding Positive Regulation Of Protein Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Apoptotic Process Regulation Of Protein Metabolic Process Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Cellular Metabolic Process Neurotrophin Signaling Pathway Programmed Cell Death Positive Regulation Of Hydrolase Activity Regulation Of Kinase Activity Regulation Of Cellular Amino Acid Metabolic Process Cell Death Death Protein Prenylation Wound Healing Blood Coagulation Small GTPase Mediated Signal Transduction Hemostasis Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Response To Organic Substance Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Phosphatidylinositol-3-phosphate Biosynthetic Process
Tagcloud ?		1b activators associates bodies cascades cdk5 coimmunoprecipitation coinciding colocalization cortical dopamine guanidine guanine insights interacted lamination microtubule neuron neurotransmitter p35 p39 phosphorylates proline proper rac releasing serine737 talk transduction	bitransgenic coexpressed coexpression contributions cooperate crypt d11137 dedifferentiation describing dysplastic enterocyte enterocytes expresses geographically oncoproteins organized p107 perturb postmitotic reenter retains simian sv40 tag tagd11137 tagwt val val12 villus
Tagcloud (Difference) ?		1b activators associates bodies cascades cdk5 coimmunoprecipitation coinciding colocalization cortical dopamine guanidine guanine insights interacted lamination microtubule neuron neurotransmitter p35 p39 phosphorylates proline proper rac releasing serine737 talk transduction	bitransgenic coexpressed coexpression contributions cooperate crypt d11137 dedifferentiation describing dysplastic enterocyte enterocytes expresses geographically oncoproteins organized p107 perturb postmitotic reenter retains simian sv40 tag tagd11137 tagwt val val12 villus
Tagcloud (Intersection) ?