RASGRF2

Gene Name		Ras protein-specific guanine nucleotide-releasing factor 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Cytosol Plasma Membrane
	Molecular Function	Rho Guanyl-nucleotide Exchange Factor Activity Calmodulin Binding
	Biological Process	Small GTPase Mediated Signal Transduction Synaptic Transmission Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity
Pathways		Signaling by GPCR Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling CREB phosphorylation through the activation of Ras Rho GTPase cycle GPCR downstream signaling Activation of NMDA receptor upon glutamate binding and postsynaptic events NRAGE signals death through JNK Signaling by Rho GTPases G alpha (12/13) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses Post NMDA receptor activation events Ras activation uopn Ca2+ infux through NMDA receptor
Drugs
Diseases
GWAS		Eating disorders ( 23568457) Eating disorders (purging via substances) ( 23568457) Orofacial clefts ( 22419666)
Protein-protein Interactions		1 interactors: KRAS
Entrez ID		5924
HPRD ID		07588
Ensembl ID		ENSG00000113319
Uniprot IDs		O14827 Q68DX5
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Rac Protein Signal Transduction Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Monooxygenase Activity Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synaptic Transmission, GABAergic Regulation Of Rac Protein Signal Transduction Regulation Of Nitric-oxide Synthase Activity Response To Mineralocorticoid Positive Regulation Of Oxidoreductase Activity Social Behavior Epithelial Tube Branching Involved In Lung Morphogenesis Positive Regulation Of Ras Protein Signal Transduction Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Small GTPase Mediated Signal Transduction Visual Learning Visual Behavior Activation Of MAPKK Activity Lung Morphogenesis Regulation Of Oxidoreductase Activity Associative Learning Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Learning Insulin Receptor Signaling Pathway Response To Glucocorticoid Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Synaptic Plasticity Response To Corticosteroid Negative Regulation Of Neuron Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Neuron Death Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of MAP Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Ras Protein Signal Transduction Neurotrophin Signaling Pathway Leukocyte Migration Fc-epsilon Receptor Signaling Pathway MAPK Cascade Striated Muscle Cell Differentiation Regulation Of Neuron Apoptotic Process Morphogenesis Of A Branching Epithelium Lung Development Morphogenesis Of A Branching Structure Respiratory Tube Development
Tagcloud ?		1b activators associates bodies cascades cdk5 coimmunoprecipitation coinciding colocalization cortical dopamine guanidine guanine insights interacted lamination microtubule neuron neurotransmitter p35 p39 phosphorylates proline proper rac releasing serine737 talk transduction