PARP16

Description		poly(ADP-ribose) polymerase family member 16
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GO Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Endoplasmic Reticulum Tubular Network
	Molecular Function	NAD+ Poly-ADP-ribosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Nucleotidyltransferase Activity Kinase Binding Protein Serine/threonine Kinase Activator Activity NAD+-protein-lysine ADP-ribosyltransferase Activity NAD+-protein-aspartate ADP-ribosyltransferase Activity NAD+-protein-glutamate ADP-ribosyltransferase Activity NAD+-protein Mono-ADP-ribosyltransferase Activity
	Biological Process	Cytoplasmic Translation Response To Unfolded Protein Viral Protein Processing Endoplasmic Reticulum Unfolded Protein Response NAD+ Biosynthetic Process Via The Salvage Pathway IRE1-mediated Unfolded Protein Response Protein Auto-ADP-ribosylation Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Cytoplasmic Translation
Pathways		Nicotinate metabolism Maturation of nucleoprotein Maturation of nucleoprotein
Drugs
Diseases
GWAS
Interacting Genes		2 interacting genes: GMCL1 NEDD4
Entrez ID		54956
HPRD ID		07919
Ensembl ID		ENSG00000138617
Uniprot IDs		Q8N5Y8
PDB IDs		4F0D 6HXR 6HXS 6W65
Enriched GO Terms of Interacting Partners?		Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Channel Inhibitor Activity Phosphoserine Residue Binding Nuclear Receptor-mediated Corticosteroid Signaling Pathway Beta-2 Adrenergic Receptor Binding Phosphothreonine Residue Binding Negative Regulation Of Potassium Ion Export Across Plasma Membrane Formation Of Structure Involved In A Symbiotic Process Sodium Channel Inhibitor Activity Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Potassium Ion Export Across Plasma Membrane Progesterone Receptor Signaling Pathway Potassium Channel Inhibitor Activity Endocardial Cushion Development Negative Regulation Of Sodium Ion Transport Proline-rich Region Binding Receptor Catabolic Process RNA Polymerase Binding Negative Regulation Of Potassium Ion Transmembrane Transport Apicolateral Plasma Membrane Postsynaptic Cytosol Ionotropic Glutamate Receptor Binding Protein Targeting To Lysosome Viral Budding Negative Regulation Of Potassium Ion Transport Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Neuromuscular Junction Development
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