HIF3A and EGLN3

Number of citations of the paper that reports this interaction (PMID 15474027)
19

Data Source:
HPRD (in vitro)

		HIF3A	EGLN3
Gene Name		hypoxia inducible factor 3, alpha subunit	egl-9 family hypoxia-inducible factor 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Transcription Corepressor Activity Signal Transducer Activity Protein Dimerization Activity	Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors L-ascorbic Acid Binding Peptidyl-proline 4-dioxygenase Activity
	Biological Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Signal Transduction Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia Negative Regulation Of Nucleic Acid-templated Transcription	Response To Hypoxia Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Protein Hydroxylation Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Regulation Of Cell Proliferation Regulation Of Neuron Apoptotic Process Oxidation-reduction Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia
Pathways		Cellular response to hypoxia Transcriptional regulation of pluripotent stem cells Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Regulation of gene expression by Hypoxia-inducible Factor	Cellular response to hypoxia Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: EGLN1 EGLN2 EGLN3 HIF1A HSP90AA1 VHL	22 interactors: ABI2 ADRB2 ATF4 EFHC2 EPAS1 FOXJ2 HIF1A HIF3A IKBKG MAPK1 MAPK6 MAPK7 NCAPH2 OS9 PKM PRPF19 REL SERTAD1 SIAH2 SQSTM1 TTC23L WDR83
Entrez ID		64344	112399
HPRD ID		17104	06972
Ensembl ID		ENSG00000124440	ENSG00000129521
Uniprot IDs		B2RBI6 F5H884 H0YDZ5 Q9Y2N7	Q9H6Z9
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Response To Hypoxia Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Peptidyl-proline Hydroxylation Response To Abiotic Stimulus 4-hydroxyproline Metabolic Process Protein Hydroxylation Cellular Response To Stress Oxygen Homeostasis Monocarboxylic Acid Metabolic Process Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Neuron Apoptotic Process Cellular Modified Amino Acid Metabolic Process Alpha-amino Acid Metabolic Process Regulation Of Neuron Death Regulation Of Nitric-oxide Synthase Activity Carboxylic Acid Metabolic Process Small Molecule Metabolic Process Organic Acid Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Amino Acid Metabolic Process Regulation Of Oxidoreductase Activity Protein Metabolic Process Regulation Of Apoptotic Process Regulation Of Cell Death Neural Fold Elevation Formation Cardiac Ventricle Development Positive Regulation Of Metabolic Process Embryonic Placenta Development Cellular Response To Stimulus Elastin Metabolic Process Negative Regulation Of CAMP Catabolic Process Cardiac Chamber Development Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Chemokine-mediated Signaling Pathway Vascular Endothelial Growth Factor Production Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Protein Import Into Mitochondrial Outer Membrane Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Intestinal Epithelial Cell Maturation Placenta Development Regulation Of Transcription, DNA-templated	Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Stress Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Signal Transduction Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Metabolic Process Negative Regulation Of Oxidative Stress-induced Cell Death Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Response To Stress Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Signal Transduction Negative Regulation Of Cell Death Regulation Of Cellular Response To Oxidative Stress Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway RNA Metabolic Process Signaling Cellular Response To Stimulus Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Cell Communication Regulation Of Gene Expression TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Oxidative Stress Negative Regulation Of Oxidative Stress-induced Neuron Death MyD88-independent Toll-like Receptor Signaling Pathway Negative Regulation Of Neuron Death Toll-like Receptor 3 Signaling Pathway Gene Expression Regulation Of Protein Metabolic Process MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Transcription, DNA-templated MAPK Cascade Positive Regulation Of Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Transcription, DNA-templated
Tagcloud ?		10b 181a 193a 20a 23b 376c 3p 5p 92b anhydrase ca9 carbonic chemoresistance deep gbm glioblastoma glioma hif1a hypoxia hypoxic isomirs micrornas mir mirnas player signature transcriptome u251mg u87mg	altering avenue cyclin d1 deubiquitinase egln1 egln2 foxo foxo3a hif hydroxylases hydroxylate hydroxylation insights leads pharmacologically prevents prolyl promotes promoting proteasomal regulate repress stability suppresses thereby turn usp9x
Tagcloud (Difference) ?		10b 181a 193a 20a 23b 376c 3p 5p 92b anhydrase ca9 carbonic chemoresistance deep gbm glioblastoma glioma hif1a hypoxia hypoxic isomirs micrornas mir mirnas player signature transcriptome u251mg u87mg	altering avenue cyclin d1 deubiquitinase egln1 egln2 foxo foxo3a hif hydroxylases hydroxylate hydroxylation insights leads pharmacologically prevents prolyl promotes promoting proteasomal regulate repress stability suppresses thereby turn usp9x
Tagcloud (Intersection) ?