HIF3A and EGLN1

Number of citations of the paper that reports this interaction (PubMedID 15474027)
0

Data Source:
HPRD (in vitro)

		HIF3A	EGLN1
Description		hypoxia inducible factor 3 subunit alpha	egl-9 family hypoxia inducible factor 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion Cytosol Plasma Membrane Nuclear Speck	Nucleus Cytoplasm Cytosol Postsynaptic Density Glutamatergic Synapse
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity	Enzyme Inhibitor Activity Iron Ion Binding Protein Binding Ferrous Iron Binding Zinc Ion Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen 2-oxoglutarate-dependent Dioxygenase Activity Enzyme Binding L-ascorbic Acid Binding Peptidyl-proline Dioxygenase Activity Peptidyl-proline 4-dioxygenase Activity Metal Ion Binding Dioxygenase Activity Hypoxia-inducible Factor-proline Dioxygenase Activity
	Biological Process	Angiogenesis Response To Hypoxia Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Apoptotic Process Intracellular Oxygen Homeostasis Cellular Response To Hypoxia	Response To Hypoxia Intracellular Iron Ion Homeostasis Intracellular Oxygen Homeostasis Regulation Of Neuron Apoptotic Process Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Cardiac Muscle Tissue Morphogenesis Heart Trabecula Formation Ventricular Septum Morphogenesis Labyrinthine Layer Development Cellular Response To Hypoxia Response To Nitric Oxide Regulation Of Modification Of Postsynaptic Structure Regulation Protein Catabolic Process At Postsynapse Negative Regulation Of Hypoxia-inducible Factor-1alpha Signaling Pathway
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Transcriptional regulation of pluripotent stem cells Neddylation	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Drugs			Ascorbic acid Iron Roxadustat N-[(4-HYDROXY-8-IODOISOQUINOLIN-3-YL)CARBONYL]GLYCINE FG-2216 Daprodustat Vadadustat Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
Diseases			Congenital polycythemia; Familial erythrocytosis (ECYT)
GWAS		Free cholesterol levels in medium VLDL ( 29084231) Medium VLDL particle concentration ( 29084231) Phospholipid levels in large VLDL ( 29084231) Phospholipid levels in medium VLDL ( 29084231) Phospholipid levels in small VLDL ( 29084231) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy) ( 24554482) Small VLDL particle concentration ( 29084231) Total cholesterol levels in medium VLDL ( 29084231) Total triglycerides levels ( 29084231) Triglyceride levels in large VLDL ( 29084231) Triglyceride levels in medium VLDL ( 29084231) Triglyceride levels in small VLDL ( 29084231) Very large VLDL particle concentration ( 29084231) Weight ( 28552196)	Cutaneous mastocytosis ( 32752121) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) High altitude adaptation ( 28373541) Metabolite levels ( 23823483) Red blood cell count ( 27863252 32888494)
Interacting Genes		7 interacting genes: ARNT EGLN1 EGLN2 EGLN3 HIF1A HSP90AA1 VHL	12 interacting genes: EPAS1 HIF1A HIF3A HSP90AA1 ING4 KRAS OS9 PLD1 SH3KBP1 SRC VHL ZNF281
Entrez ID		64344	54583
HPRD ID		17104	06971
Ensembl ID		ENSG00000124440	ENSG00000135766
Uniprot IDs		B2RBI6 H0YDZ5 M0R104 Q9Y2N7	Q9GZT9 R4SCQ0
PDB IDs		4WN5	2G19 2G1M 2HBT 2HBU 2Y33 2Y34 3HQR 3HQU 3OUH 3OUI 3OUJ 4BQW 4BQX 4BQY 4JZR 4KBZ 4UWD 5A3U 5L9B 5L9R 5L9V 5LA9 5LAS 5LAT 5LB6 5LBB 5LBC 5LBE 5LBF 5OX5 5OX6 5V18 6NMQ 6QGV 6ST3 6YVT 6YVW 6YVX 6YVZ 6YW0 6YW1 6YW2 6YW3 6YW4 6ZBN 6ZBO 7Q5V 7Q5X 7UJV 7UMP 8J1K 8Q5S 8Q64 8Q6D 8Q6E 8RUT 8RUV 8RUZ 8RV1 8Y0V 8Z31 8Z32 8Z33 8Z35
Enriched GO Terms of Interacting Partners?		Peptidyl-proline 4-dioxygenase Activity Response To Hypoxia Response To Decreased Oxygen Levels Hypoxia-inducible Factor-proline Dioxygenase Activity Response To Oxygen Levels Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels L-ascorbic Acid Binding 2-oxoglutarate-dependent Dioxygenase Activity Cellular Response To Stress Ferrous Iron Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Regulation Of Neuron Apoptotic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Dioxygenase Activity Positive Regulation Of Hormone Biosynthetic Process Intracellular Oxygen Homeostasis Response To Stress Iron Ion Binding Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Protein Hydroxylation Regulation Of Hormone Biosynthetic Process Positive Regulation Of Glycolytic Process Positive Regulation Of Catabolic Process Regulation Of Cellular Response To Hypoxia Embryonic Placenta Development Positive Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Erythrocyte Differentiation Regulation Of Hormone Metabolic Process Regulation Of Post-translational Protein Modification Positive Regulation Of ATP Metabolic Process Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Erythrocyte Differentiation Regulation Of Glycolytic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Carbohydrate Catabolic Process Regulation Of Nitric Oxide Metabolic Process Intracellular Iron Ion Homeostasis Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of ATP Metabolic Process Cellular Response To Virus Enzyme Binding CTP Binding DATP Binding Regulation Of Purine Nucleotide Metabolic Process	Intracellular Oxygen Homeostasis Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Cellular Response To Hypoxia Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Apoptotic Process TOR Signaling Programmed Cell Death Cell Death Negative Regulation Of TOR Signaling Response To Hypoxia Cellular Response To Stress Response To Decreased Oxygen Levels Positive Regulation Of Multicellular Organismal Process Response To Oxygen Levels Regulation Of Protein Neddylation Regulation Of Macromolecule Metabolic Process Positive Regulation Of Glycolytic Process Epithelial Cell Maturation Embryonic Placenta Development Homeostatic Process Regulation Of TOR Signaling Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Dimerization Activity Regulation Of Gene Expression Hemopoiesis Positive Regulation Of Lamellipodium Organization Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of ATP Metabolic Process Regulation Of Apoptotic Process Cell Migration Macromolecule Metabolic Process Multicellular Organismal-level Homeostasis Regulation Of Heart Contraction Regulation Of Primary Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Localization Regulation Of Neuroblast Proliferation Transcription Regulator Complex Intracellular Chemical Homeostasis Transcription Coactivator Binding Response To Stress Regulation Of Post-translational Protein Modification
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