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DET1 and RFWD2
Number of citations of the paper that reports this interaction (PMID
14739464
)
99
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology)
HPRD
(in vitro)
DET1
RFWD2
Gene Name
de-etiolated homolog 1 (Arabidopsis)
ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Golgi Membrane
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Focal Adhesion
Nuclear Speck
Molecular Function
Protein Binding
Zinc Ion Binding
Ligase Activity
Ubiquitin Protein Ligase Activity
Biological Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Response To Ionizing Radiation
Protein Ubiquitination
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
p53-Dependent G1 DNA Damage Response
Autodegradation of the E3 ubiquitin ligase COP1
Stabilization of p53
Cell Cycle Checkpoints
p53-Dependent G1/S DNA damage checkpoint
G1/S DNA Damage Checkpoints
Drugs
Diseases
GWAS
Protein-Protein Interactions
2 interactors:
DDB1
RFWD2
14 interactors:
CCT4
DET1
ETS1
ETS2
JUN
JUND
PTPN1
RB1CC1
SFN
SIPA1
TP53
UBE2D1
UBE2D2
YWHAZ
Entrez ID
55070
64326
HPRD ID
13140
07455
Ensembl ID
ENSG00000140543
ENSG00000143207
Uniprot IDs
Q7L5Y6
Q05CT6
Q8NHY2
PDB IDs
Enriched GO Terms of Interacting Partners
?
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Cell Cycle Phase Transition
Positive Regulation By Virus Of Viral Protein Levels In Host Cell
Regulation Of Mitotic Cell Cycle
Response To Radiation
Regulation Of Cell Cycle Process
UV-damage Excision Repair
Positive Regulation Of Viral Release From Host Cell
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Histone H2A Monoubiquitination
Histone H2A Ubiquitination
Cellular Response To DNA Damage Stimulus
Nucleotide-excision Repair, DNA Damage Removal
Regulation Of Cell Cycle
Histone Monoubiquitination
Positive Regulation Of Viral Genome Replication
Regulation Of Viral Release From Host Cell
Response To Abiotic Stimulus
Interaction With Symbiont
Histone Ubiquitination
Protein Monoubiquitination
Cellular Response To Stress
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Signal Transduction Involved In DNA Damage Checkpoint
Cellular Response To UV
Signal Transduction Involved In Cell Cycle Checkpoint
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Viral Genome Replication
Positive Regulation Of Proteasomal Protein Catabolic Process
Mitotic G1 DNA Damage Checkpoint
Positive Regulation Of Viral Process
Mitotic G1/S Transition Checkpoint
G1 DNA Damage Checkpoint
Positive Regulation Of Cell Cycle Arrest
DNA Damage Response, Signal Transduction By P53 Class Mediator
Signal Transduction In Response To DNA Damage
Cellular Response To Light Stimulus
Nucleotide-excision Repair
Mitotic DNA Damage Checkpoint
Regulation Of Cell Cycle Arrest
Mitotic DNA Integrity Checkpoint
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Signal Transduction By P53 Class Mediator
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Response To UV
Regulation Of Cell Cycle G1/S Phase Transition
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Stress
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Release Of Cytochrome C From Mitochondria
Response To Abiotic Stimulus
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Response To Stress
Immune Response
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Transcription From RNA Polymerase II Promoter
Regulation Of DNA-templated Transcription In Response To Stress
Positive Regulation Of Mitochondrion Organization
Cellular Response To Extracellular Stimulus
Regulation Of Cell Cycle
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Apoptotic Mitochondrial Changes
Regulation Of Innate Immune Response
Toll-like Receptor 4 Signaling Pathway
Response To Hypoxia
Regulation Of Mitochondrion Organization
Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Response To Hypoxia
Intracellular Signal Transduction
Cellular Response To Decreased Oxygen Levels
Response To Wounding
Regulation Of Cellular Component Organization
Toll-like Receptor Signaling Pathway
Apoptotic Signaling Pathway
Cellular Response To Oxygen Levels
Cellular Response To Stimulus
Mitochondrion Organization
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Immune System Process
Cellular Response To Starvation
Transforming Growth Factor Beta Receptor Signaling Pathway
Activation Of Innate Immune Response
Regulation Of Apoptotic Process
Organelle Organization
RNA Metabolic Process
Transcription, DNA-templated
Negative Regulation Of Cell Cycle
Negative Regulation Of Apoptotic Process
Regulation Of Cell Death
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Response To Endoplasmic Reticulum Stress
Negative Regulation Of Programmed Cell Death
Response To Extracellular Stimulus
Tagcloud
?
3c
collections
endo
exo
gal1
histidine
hydrolyzes
hydrophilic
individually
library
morf
movable
mutases
nuclease
nucleases
orf
phosphatases
phosphoglycerate
plasmids
pools
radiolabeled
sepharose
tag
tagged
tripartite
undertook
ydr051c
yor283w
zz
Tagcloud (Difference)
?
3c
collections
endo
exo
gal1
histidine
hydrolyzes
hydrophilic
individually
library
morf
movable
mutases
nuclease
nucleases
orf
phosphatases
phosphoglycerate
plasmids
pools
radiolabeled
sepharose
tag
tagged
tripartite
undertook
ydr051c
yor283w
zz
Tagcloud (Intersection)
?