DET1

Description		DET1 partner of COP1 E3 ubiquitin ligase
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GO Annotations	Cellular Component	Nucleus Cullin-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex Assembly
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Menarche (age at onset) ( 25231870) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		2 interacting genes: COP1 DDB1
Entrez ID		55070
HPRD ID		13140
Ensembl ID		ENSG00000140543
Uniprot IDs		Q7L5Y6
PDB IDs		9DHD
Enriched GO Terms of Interacting Partners?		Cul4A-RING E3 Ubiquitin Ligase Complex Protein Catabolic Process Base-excision Repair, AP Site Formation Via Deaminated Base Removal Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Complex Scaffold Activity Regulation Of Protein Catabolic Process UV-damage Excision Repair WD40-repeat Domain Binding Response To Radiation Proteasomal Protein Catabolic Process Positive Regulation Of Catabolic Process Positive Regulation Of Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cul4B-RING E3 Ubiquitin Ligase Complex Positive Regulation By Virus Of Viral Protein Levels In Host Cell Protein Ubiquitination Spindle Assembly Involved In Female Meiosis Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Epigenetic Programming In The Zygotic Pronuclei Meiotic Spindle Assembly Base-excision Repair, AP Site Formation Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Protein Metabolic Process Post-translational Protein Modification Programmed Cell Death Involved In Cell Development Meiotic Spindle Organization Positive Regulation Of Gluconeogenesis Cullin Family Protein Binding Cul4-RING E3 Ubiquitin Ligase Complex Viral Release From Host Cell Positive Regulation Of Viral Genome Replication Macromolecule Catabolic Process Epigenetic Programming Of Gene Expression Biological Process Involved In Interaction With Symbiont Proteolysis Positive Regulation Of Glucose Metabolic Process Nucleotide-excision Repair Type I Interferon-mediated Signaling Pathway Regulation Of Gluconeogenesis Positive Regulation Of Viral Process Damaged DNA Binding Regulation Of Protein Metabolic Process Negative Regulation Of Reproductive Process Interferon-mediated Signaling Pathway Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Modification Process Regulation Of Viral Genome Replication Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
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