NR6A1 and UIMC1

Number of citations of the paper that reports this interaction (PubMedID 17416745)
37

Data Source:
HPRD (two hybrid, in vitro)

		NR6A1	UIMC1
Description		nuclear receptor subfamily 6 group A member 1	ubiquitin interaction motif containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex	Nucleus Nucleoplasm Nuclear Body Site Of Double-strand Break BRCA1-A Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Zinc Ion Binding Estrogen Response Element Binding Protein Homodimerization Activity Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	DNA Binding Protein Binding Zinc Ion Binding Histone Binding Metal Ion Binding Ubiquitin-modified Histone Reader Activity K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Gamete Generation Intracellular Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Mesenchymal Stem Cell Differentiation	DNA Repair Regulation Of DNA Repair Double-strand Break Repair Chromatin Organization DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Response To Ionizing Radiation Mitotic G2/M Transition Checkpoint Positive Regulation Of DNA Repair Negative Regulation Of DNA-templated Transcription DNA Repair-dependent Chromatin Remodeling
Pathways			Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Menarche (age at onset) ( 27182965)	Activated partial thromboplastin time ( 22703881) Menarche and menopause (age at onset) ( 19448621) Menopause (age at onset) ( 22267201 26414677 29773799) Uterine fibroids ( 31649266) Waist circumference adjusted for body mass index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		6 interacting genes: DNMT3L GNB5 NCOA1 NCOR1 NSD1 UIMC1	22 interacting genes: ABRAXAS1 ATP8A2 CEP57 CREBBP DVL2 ECPAS ESR1 FANCG H2AC20 INO80B MDC1 NR6A1 RAD23A SKIL SUMO2 TP53 TRAIP UBB UBC USP13 WBP2 ZMYM3
Entrez ID		2649	51720
HPRD ID		04147	11482
Ensembl ID		ENSG00000148200	ENSG00000087206
Uniprot IDs		F1D8S0 F1DAM1 Q15406	Q96RL1
PDB IDs			2MKF 2MKG 2N9E 2RR9
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Binding Chromatin Organization Nuclear Retinoid X Receptor Binding Nuclear Retinoic Acid Receptor Binding Chromatin Remodeling Nuclear Thyroid Hormone Receptor Binding Nuclear Estrogen Receptor Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter By Galactose GTPase Activator Complex G-protein Gamma-subunit Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Labyrinthine Layer Morphogenesis Negative Regulation Of RNA Metabolic Process Dark Adaptation Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Cellular Response To Thyroglobulin Triiodothyronine Regulation Of RNA Biosynthetic Process Positive Regulation Of Female Receptivity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Light Adaption Epigenetic Programing Of Female Pronucleus Histone H3K36 Dimethyltransferase Activity Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Response To Thyroglobulin Triiodothyronine Regulation Of Female Receptivity Regulation Of Thyroid Hormone Receptor Signaling Pathway Male Mating Behavior Female Mating Behavior Nucleus Carbon Catabolite Regulation Of Transcription Transcription Corepressor Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Cell Tip Chorionic Trophoblast Cell Differentiation Autosome Genomic Imprinting Negative Regulation Of Heterochromatin Formation Methylation BRCA1-A Complex Ubiquitin-modified Histone Reader Activity Histone H4K20 Methyltransferase Activity Rhythmic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Heterochromatin Formation Histone H3K36 Methyltransferase Activity Negative Regulation Of Biosynthetic Process Estrous Cycle	Nucleoplasm Nucleus DNA Repair DNA Damage Response Protein Tag Activity Proteasome Binding DNA Metabolic Process Regulation Of Cellular Response To Stress Nuclear Body Chromatin Organization Transcription Regulator Complex Cellular Response To Stress Positive Regulation Of DNA Repair Positive Regulation Of Macromolecule Metabolic Process Transcription Coactivator Binding Ubiquitin Protein Ligase Binding Post-translational Protein Modification Damaged DNA Binding Estrogen Response Element Binding Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Mitotic DNA Damage Checkpoint Signaling Positive Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Proteolysis Mitotic DNA Integrity Checkpoint Signaling Regulation Of Proteasomal Protein Catabolic Process Chromatin Remodeling Regulation Of Macromolecule Metabolic Process Regulation Of DNA Repair Cellular Response To Estrogen Stimulus Response To Radiation Intracellular Signal Transduction DNA Damage Checkpoint Signaling Regulation Of Cell Cycle PML Body Regulation Of DNA Metabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of DNA Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Ubiquitin-like Protein Ligase Binding Regulation Of Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process 14-3-3 Protein Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Signal Transduction By P53 Class Mediator Determination Of Adult Lifespan Positive Regulation Of RNA Biosynthetic Process Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription
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