NR6A1 and GNB5

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		NR6A1	GNB5
Gene Name		nuclear receptor subfamily 6, group A, member 1	guanine nucleotide binding protein (G protein), beta 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Transcription Factor Complex	Nucleus Plasma Membrane
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Zinc Ion Binding Protein Homodimerization Activity Sequence-specific DNA Binding	GTPase Activity Signal Transducer Activity Protein Binding G-protein Gamma-subunit Binding Chaperone Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Gamete Generation Spermatogenesis Cell Proliferation Gene Expression Intracellular Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter	Signal Transduction Phototransduction, Visible Light Metabolic Process Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Negative Regulation Of Voltage-gated Calcium Channel Activity
Pathways			G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Glucagon-type ligand receptors Signal amplification Signaling by Wnt G beta:gamma signalling through PLC beta Metabolic disorders of biological oxidation enzymes G beta:gamma signalling through PI3Kgamma Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (12/13) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Class B/2 (Secretin family receptors) ADP signalling through P2Y purinoceptor 12 Prostacyclin signalling through prostacyclin receptor G-protein beta:gamma signalling Vasopressin regulates renal water homeostasis via Aquaporins Opioid Signalling Regulation of insulin secretion Activation of Kainate Receptors upon glutamate binding GPCR ligand binding Aquaporin-mediated transport beta-catenin independent WNT signaling Adrenaline,noradrenaline inhibits insulin secretion Thrombin signalling through proteinase activated receptors (PARs) G alpha (q) signalling events Presynaptic function of Kainate receptors GPCR downstream signaling Platelet homeostasis Ca2+ pathway G-protein activation Platelet activation, signaling and aggregation Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: GNB5 NCOA1 NCOR1 NSD1 UIMC1	26 interactors: ANXA7 APP BNIP3L CDKN1A CSNK2B E2F2 EIF3J GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNGT1 MCM2 MVD NR6A1 OLFM2 PSD PSMD4 RGS11 RGS6 RGS7 RGS9 RPA1 TSC22D1
Entrez ID		2649	10681
HPRD ID		04147	09191
Ensembl ID		ENSG00000148200	ENSG00000069966
Uniprot IDs		F1D8S0 F1DAM1 Q15406	B3KWS4 O14775
PDB IDs
Enriched GO Terms of Interacting Partners?		Chromatin Modification Chromatin Organization Chromosome Organization Histone Modification Diencephalon Development Regulation Of Glycolytic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter By Galactose Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Histone H2A K63-linked Deubiquitination Regulation Of Cellular Response To Drug CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Response To Drug Definitive Erythrocyte Differentiation Regulatory T Cell Differentiation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Peptidyl-lysine Modification Negative Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Female Receptivity Organelle Organization RNA Metabolic Process Male Mating Behavior Negative Regulation Of Gene Expression Rhythmic Process Negative Regulation Of Biosynthetic Process Carbon Catabolite Regulation Of Transcription Positive Regulation Of Metabolic Process Gene Expression Histone H3-K36 Methylation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Thalamus Development Regulation Of Female Receptivity Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Forebrain Development Response To Radiation Female Mating Behavior Protein K63-linked Deubiquitination Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Histone H4-K20 Methylation Histone Deubiquitination Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cation Channel Activity Positive Regulation Of Histone Deacetylation Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Transcription, DNA-templated	Cellular Response To Glucagon Stimulus Response To Glucagon Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway Response To Hormone Cellular Response To Stimulus Signal Transduction Cellular Response To Hormone Stimulus Signaling Cell Communication Response To Stimulus Regulation Of Cellular Process Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Energy Derivation By Oxidation Of Organic Compounds Cell Surface Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Response To Organic Substance Generation Of Precursor Metabolites And Energy Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Signal Transduction Cellular Response To Organic Substance Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Response To Organonitrogen Compound G1/S Transition Of Mitotic Cell Cycle Synaptic Transmission Regulation Of Signaling Mitotic Cell Cycle Cellular Response To Light Stimulus Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Signal Transduction By P53 Class Mediator Regulation Of Metabolic Process Cell-cell Signaling Regulation Of Rhodopsin Mediated Signaling Pathway Positive Regulation Of Metabolic Process Response To Light Stimulus DNA Strand Elongation Involved In DNA Replication Cellular Process Cellular Response To Radiation Apoptotic Process DNA Strand Elongation Small Molecule Metabolic Process Rhodopsin Mediated Signaling Pathway
Tagcloud ?		anteroposterior antimorph antisense cyp26 degrading derepressed embryos enhances gcnf germ hindbrain laevis morpholino nervous neuroectoderm neurogenesis oligonucleotide orphan patterning posterior presumptive ra relevance repressor spatiotemporal specification transiently xemgcnf xenopus
Tagcloud (Difference) ?		anteroposterior antimorph antisense cyp26 degrading derepressed embryos enhances gcnf germ hindbrain laevis morpholino nervous neuroectoderm neurogenesis oligonucleotide orphan patterning posterior presumptive ra relevance repressor spatiotemporal specification transiently xemgcnf xenopus
Tagcloud (Intersection) ?