NFIX and MLLT1

		NFIX	MLLT1
Description		nuclear factor I X	MLLT1 super elongation complex subunit
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GO Annotations	Cellular Component	Chromatin Nucleus	Fibrillar Center Nucleus Nucleoplasm Cytosol Transcription Elongation Factor Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Chromatin Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Positive Regulation Of DNA-templated Transcription
Pathways		RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation
Drugs
Diseases			Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Bipolar disorder ( 28115744) Body mass index ( 25673413) Brain morphology (MOSTest) ( 32665545) Clozapine-induced agranulocytosis ( 25187353) Cortical surface area ( 32963231) Cortical volume ( 32963231) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Hemoglobin ( 32888494) Hip index ( 34021172) Intelligence (MTAG) ( 29326435) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Plateletcrit ( 32888494) Refractive error ( 32231278)	Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 27021288)
Interacting Genes		24 interacting genes: JMJD6 LHX4 NFIB PAX2 PAX6 PAX7 PAX8 PIR PRDM1 QRICH1 RFX1 SKI SOX10 SOX15 SOX17 SOX5 SOX6 SOX9 SP7 TBR1 TLX2 TLX3 YY1 ZNF614	13 interacting genes: AFF1 AFF4 ALKBH4 ARID1A BMI1 CBX8 FXR1 H1-5 H3-4 MLLT10 PAF1 WDR5 YIF1A
Entrez ID		4784	4298
HPRD ID		01234	15933
Ensembl ID		ENSG00000008441	ENSG00000130382
Uniprot IDs		B4DHW2 D2DXM9 Q14938	Q03111
PDB IDs		7QQD 7QQE	5J9S 6HPW 6HPX 6HPY 6HPZ 6HQ0 6HT0 6HT1 6T1I 6T1J 6T1L 6T1M 6T1N 6T1O 7B0T 7B10 7E74 7E7A 7E7C 7X88 7X8B 7X8F 7X8G 8PJI
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Chromatin DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Animal Organ Development Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Cis-regulatory Region Binding Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cellular Developmental Process Positive Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Positive Regulation Of RNA Metabolic Process Nucleus Positive Regulation Of Stem Cell Differentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Metanephric Nephron Tubule Formation Regulation Of Gene Expression Cell Fate Commitment Gene Expression Regulation Of Macromolecule Biosynthetic Process Glial Cell Differentiation Negative Regulation Of Developmental Process Metanephric Tubule Formation Positive Regulation Of Mesenchymal Stem Cell Differentiation Regulation Of Macromolecule Metabolic Process Lacrimal Gland Development Developmental Process Glial Cell Fate Specification Ureter Development Regulation Of Developmental Process Regulation Of Cell Differentiation Neuron Differentiation Positive Regulation Of Macromolecule Metabolic Process Retina Development In Camera-type Eye Regulation Of Stem Cell Differentiation Pattern Specification Process Regionalization	Heterochromatin Chromatin Organization Regulation Of Macromolecule Biosynthetic Process Chromatin Remodeling Regulation Of Gene Expression Super Elongation Complex Positive Regulation Of Gene Expression, Epigenetic Ubiquitin-protein Transferase Activator Activity Nucleus Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Epigenetic Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process PRC1 Complex Regulation Of Metabolic Process Transcription Elongation Factor Complex Nucleosome Organization Positive Regulation Of Macromolecule Metabolic Process PcG Protein Complex Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleosome Binding Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Chromatin Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Initiation-coupled Chromatin Remodeling Histone H3Q5ser Reader Activity DNA N6-methyladenine Demethylase Activity Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Euchromatin Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Adaxial/abaxial Pattern Formation Histone H3K4me1 Reader Activity Cleavage Furrow Ingression Positive Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Structural Constituent Of Chromatin Positive Regulation Of Macromolecule Biosynthetic Process RING-like Zinc Finger Domain Binding Rostrocaudal Neural Tube Patterning Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Spermatid Development
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