NFIX and ZNF614

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		NFIX	ZNF614
Description		nuclear factor I X	zinc finger protein 614
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways		RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation	Generic Transcription Pathway
Drugs
Diseases
GWAS		Bipolar disorder ( 28115744) Body mass index ( 25673413) Brain morphology (MOSTest) ( 32665545) Clozapine-induced agranulocytosis ( 25187353) Cortical surface area ( 32963231) Cortical volume ( 32963231) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Hemoglobin ( 32888494) Hip index ( 34021172) Intelligence (MTAG) ( 29326435) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Plateletcrit ( 32888494) Refractive error ( 32231278)	Bronchodilator response in asthma (inhaled corticosteroid treatment interaction) ( 24280104) Metabolite levels ( 23823483) Tourette syndrome ( 30818990)
Interacting Genes		24 interacting genes: JMJD6 LHX4 NFIB PAX2 PAX6 PAX7 PAX8 PIR PRDM1 QRICH1 RFX1 SKI SOX10 SOX15 SOX17 SOX5 SOX6 SOX9 SP7 TBR1 TLX2 TLX3 YY1 ZNF614	2 interacting genes: FAM9B NFIX
Entrez ID		4784	80110
HPRD ID		01234	15874
Ensembl ID		ENSG00000008441	ENSG00000142556
Uniprot IDs		B4DHW2 D2DXM9 Q14938	Q8N883
PDB IDs		7QQD 7QQE
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Chromatin DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Animal Organ Development Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Cis-regulatory Region Binding Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cellular Developmental Process Positive Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Positive Regulation Of RNA Metabolic Process Nucleus Positive Regulation Of Stem Cell Differentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Metanephric Nephron Tubule Formation Regulation Of Gene Expression Cell Fate Commitment Gene Expression Regulation Of Macromolecule Biosynthetic Process Glial Cell Differentiation Negative Regulation Of Developmental Process Metanephric Tubule Formation Positive Regulation Of Mesenchymal Stem Cell Differentiation Regulation Of Macromolecule Metabolic Process Lacrimal Gland Development Developmental Process Glial Cell Fate Specification Ureter Development Regulation Of Developmental Process Regulation Of Cell Differentiation Neuron Differentiation Positive Regulation Of Macromolecule Metabolic Process Retina Development In Camera-type Eye Regulation Of Stem Cell Differentiation Pattern Specification Process Regionalization
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