NFIX and PAX7

Number of citations of the paper that reports this interaction (PubMedID 35140242)
106

Data Source:
BioGRID (pull down)

		NFIX	PAX7
Description		nuclear factor I X	paired box 7
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Nervous System Development Muscle Organ Development Skeletal Muscle Tissue Development Anatomical Structure Morphogenesis Regulation Of Cell Fate Commitment Regulation Of Gene Expression Skeletal Muscle Satellite Cell Commitment Skeletal Muscle Satellite Cell Differentiation Spinal Cord Association Neuron Differentiation Dorsal/ventral Neural Tube Patterning Negative Regulation Of Apoptotic Process Skeletal Muscle Tissue Regeneration Positive Regulation Of Transcription By RNA Polymerase II Neuron Fate Commitment Embryonic Skeletal System Development Cartilage Development Muscle Tissue Morphogenesis Regulation Of Chromatin Organization Positive Regulation Of Myoblast Proliferation
Pathways		RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation	Specification of the neural plate border
Drugs
Diseases			Alveolar rhabdomyosarcoma
GWAS		Bipolar disorder ( 28115744) Body mass index ( 25673413) Brain morphology (MOSTest) ( 32665545) Clozapine-induced agranulocytosis ( 25187353) Cortical surface area ( 32963231) Cortical volume ( 32963231) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Hemoglobin ( 32888494) Hip index ( 34021172) Intelligence (MTAG) ( 29326435) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Plateletcrit ( 32888494) Refractive error ( 32231278)	Body mass index ( 23669352) Cortical surface area (visual PC2) ( 32198502) Knee osteoarthritis ( 28916551) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 33898419) Orofacial cleft x maternal periconceptional alcohol use interaction (2df) ( 33937227) Orofacial cleft x maternal periconceptional multivitamin use interaction (2df) ( 33937227) Orofacial cleft x maternal periconceptional smoking interaction (2df) ( 33937227) Orofacial clefts ( 22863734) Percentage gas trapping ( 26030696) Response to amphetamines ( 22952603) Urate levels in lean individuals ( 25811787)
Interacting Genes		24 interacting genes: JMJD6 LHX4 NFIB PAX2 PAX6 PAX7 PAX8 PIR PRDM1 QRICH1 RFX1 SKI SOX10 SOX15 SOX17 SOX5 SOX6 SOX9 SP7 TBR1 TLX2 TLX3 YY1 ZNF614	14 interacting genes: AIRIM CIB1 CSNK2A1 CT55 FHL1 HIRA HNF1B HOMER3 KRTAP19-7 MAGOHB NEDD4 NFIC NFIX TCAP
Entrez ID		4784	5081
HPRD ID		01234	01331
Ensembl ID		ENSG00000008441	ENSG00000009709
Uniprot IDs		B4DHW2 D2DXM9 Q14938	P23759
PDB IDs		7QQD 7QQE
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Chromatin DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Animal Organ Development Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Cis-regulatory Region Binding Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cellular Developmental Process Positive Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Positive Regulation Of RNA Metabolic Process Nucleus Positive Regulation Of Stem Cell Differentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Metanephric Nephron Tubule Formation Regulation Of Gene Expression Cell Fate Commitment Gene Expression Regulation Of Macromolecule Biosynthetic Process Glial Cell Differentiation Negative Regulation Of Developmental Process Metanephric Tubule Formation Positive Regulation Of Mesenchymal Stem Cell Differentiation Regulation Of Macromolecule Metabolic Process Lacrimal Gland Development Developmental Process Glial Cell Fate Specification Ureter Development Regulation Of Developmental Process Regulation Of Cell Differentiation Neuron Differentiation Positive Regulation Of Macromolecule Metabolic Process Retina Development In Camera-type Eye Regulation Of Stem Cell Differentiation Pattern Specification Process Regionalization	Transmembrane Transporter Binding Negative Regulation Of Macromolecule Biosynthetic Process Protein Targeting Negative Regulation Of Metabolic Process RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Protein Targeting To Vacuole Nucleic Acid Metabolic Process Animal Organ Morphogenesis DNA-templated Transcription Formation Of Structure Involved In A Symbiotic Process Epithelial Tube Formation Mesonephric Duct Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Mesonephric Nephron Morphogenesis Ureteric Bud Elongation Pronephric Nephron Tubule Development Mesenchymal Cell Apoptotic Process Involved In Metanephros Development HIR Complex Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Calcineurin-mediated Signaling Positive Regulation Of Male Germ Cell Proliferation Anatomical Structure Morphogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Establishment Of Protein Localization To Vacuole Regulation Of Growth Regulation Of Potassium Ion Transmembrane Transport Channel Inhibitor Activity Chromatin Hepatoblast Differentiation Regulation Of Pronephros Size Titin-telethonin Complex Titin Z Domain Binding Sarcomerogenesis Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Potassium Ion Transport Phosphothreonine Residue Binding Transcription By RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Branch Elongation Involved In Ureteric Bud Branching Mesonephric Duct Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Skeletal Muscle Myosin Thick Filament Assembly G Protein-coupled Glutamate Receptor Binding Endomitotic Cell Cycle Calcium-dependent Protein Kinase Inhibitor Activity Exon-exon Junction Subcomplex Mago-y14 Zinc Ion Import Into Golgi Lumen Protein Localization To Vacuole
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