NFIX and TLX2

Number of citations: 106 (PubMedID 35140242)
Data Source: BioGRID (pull down)

		NFIX	TLX2
Name		nuclear factor I X	T cell leukemia homeobox 2
Structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Mesoderm Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Enteric Nervous System Development Animal Organ Development Negative Regulation Of Dendrite Morphogenesis
Pathways		RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation	None
GWAS		Bipolar disorder ( 28115744 ) Body mass index ( 25673413 ) Brain morphology (MOSTest) ( 32665545 ) Clozapine-induced agranulocytosis ( 25187353 ) Cortical surface area ( 32963231 ) Cortical volume ( 32963231 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Heel bone mineral density ( 30598549 ) Hemoglobin ( 32888494 ) Hip index ( 34021172 ) Intelligence (MTAG) ( 29326435 ) Lymphocyte count ( 32888494 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Monocyte count ( 32888494 27863252 ) Monocyte percentage of white cells ( 32888494 27863252 ) Plateletcrit ( 32888494 ) Refractive error ( 32231278 )	No GWAS studies recorded
Novel Interactors		8 novel interactors: ARL4A GADD45B GZMA MATK MLLT1 NRTN POLR2E RWDD1	None recorded
Interacting Genes		24 interacting genes: JMJD6 LHX4 NFIB PAX2 PAX6 PAX7 PAX8 PIR PRDM1 QRICH1 RFX1 SKI SOX10 SOX15 SOX17 SOX5 SOX6 SOX9 SP7 TBR1 TLX2 TLX3 YY1 ZNF614	14 interacting genes: GTF2A1L HNF1B IRF6 IRF9 KRTAP6-2 MCM4 MEIS1 NFIC NFIX POU2F1 POU6F2 TLE1 YWHAH ZNF502
Entrez ID		4784	3196
HPRD ID		01234	07254
Ensembl ID		ENSG00000008441	ENSG00000115297
Uniprot IDs		B4DHW2 D2DXM9 Q14938	O43763
PDB IDs		7QQD 7QQE	3A03
GO Terms Enriched among Interactors		DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Chromatin DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Animal Organ Development Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Cis-regulatory Region Binding Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cellular Developmental Process Positive Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Positive Regulation Of RNA Metabolic Process Nucleus Positive Regulation Of Stem Cell Differentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Metanephric Nephron Tubule Formation Regulation Of Gene Expression Cell Fate Commitment Gene Expression Regulation Of Macromolecule Biosynthetic Process Glial Cell Differentiation Negative Regulation Of Developmental Process Metanephric Tubule Formation Positive Regulation Of Mesenchymal Stem Cell Differentiation Regulation Of Macromolecule Metabolic Process Lacrimal Gland Development Developmental Process Glial Cell Fate Specification Ureter Development Regulation Of Developmental Process Regulation Of Cell Differentiation Neuron Differentiation Positive Regulation Of Macromolecule Metabolic Process Retina Development In Camera-type Eye Regulation Of Stem Cell Differentiation Pattern Specification Process Regionalization	Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity Chromatin Positive Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Transcription By RNA Polymerase II DNA Replication Nucleus DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-templated Transcription Animal Organ Morphogenesis Mesonephric Duct Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Mesonephric Nephron Morphogenesis Ureteric Bud Elongation Pronephric Nephron Tubule Development Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Glucocorticoid Catabolic Process Transcription Regulator Complex Sequence-specific Double-stranded DNA Binding Transcription Cis-regulatory Region Binding Hepatoblast Differentiation Regulation Of Pronephros Size Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Branch Elongation Involved In Ureteric Bud Branching Mesonephric Duct Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Cerebellar Granule Cell To Purkinje Cell Synapse ISGF3 Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Mitotic DNA Replication Initiation