NFIX and SOX15

Number of citations of the paper that reports this interaction (PubMedID 35140242)
106

Data Source:
BioGRID (pull down)

		NFIX	SOX15
Description		nuclear factor I X	SRY-box transcription factor 15
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus Transcription Regulator Complex Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Brain Development Male Gonad Development Positive Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Cell Differentiation Neuron Differentiation Skeletal Muscle Tissue Regeneration Negative Regulation Of Striated Muscle Tissue Development Positive Regulation Of Transcription By RNA Polymerase II Myoblast Development Trophoblast Giant Cell Differentiation Positive Regulation Of G0 To G1 Transition Positive Regulation Of Myoblast Proliferation
Pathways		RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation
Drugs
Diseases
GWAS		Bipolar disorder ( 28115744) Body mass index ( 25673413) Brain morphology (MOSTest) ( 32665545) Clozapine-induced agranulocytosis ( 25187353) Cortical surface area ( 32963231) Cortical volume ( 32963231) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Hemoglobin ( 32888494) Hip index ( 34021172) Intelligence (MTAG) ( 29326435) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Plateletcrit ( 32888494) Refractive error ( 32231278)	Atrial fibrillation ( 30061737) Brain morphology (MOSTest) ( 32665545)
Interacting Genes		24 interacting genes: JMJD6 LHX4 NFIB PAX2 PAX6 PAX7 PAX8 PIR PRDM1 QRICH1 RFX1 SKI SOX10 SOX15 SOX17 SOX5 SOX6 SOX9 SP7 TBR1 TLX2 TLX3 YY1 ZNF614	6 interacting genes: BHLHE40 CFTR HNF1B HSFY1 NFIC NFIX
Entrez ID		4784	6665
HPRD ID		01234	03191
Ensembl ID		ENSG00000008441	ENSG00000129194
Uniprot IDs		B4DHW2 D2DXM9 Q14938	O60248
PDB IDs		7QQD 7QQE
Enriched GO Terms of Interacting Partners?		DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding Chromatin DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Animal Organ Development Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Cis-regulatory Region Binding Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Cellular Developmental Process Positive Regulation Of Transcription By RNA Polymerase II Cell Fate Specification Positive Regulation Of RNA Metabolic Process Nucleus Positive Regulation Of Stem Cell Differentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Metanephric Nephron Tubule Formation Regulation Of Gene Expression Cell Fate Commitment Gene Expression Regulation Of Macromolecule Biosynthetic Process Glial Cell Differentiation Negative Regulation Of Developmental Process Metanephric Tubule Formation Positive Regulation Of Mesenchymal Stem Cell Differentiation Regulation Of Macromolecule Metabolic Process Lacrimal Gland Development Developmental Process Glial Cell Fate Specification Ureter Development Regulation Of Developmental Process Regulation Of Cell Differentiation Neuron Differentiation Positive Regulation Of Macromolecule Metabolic Process Retina Development In Camera-type Eye Regulation Of Stem Cell Differentiation Pattern Specification Process Regionalization	DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Sequence-specific Double-stranded DNA Binding Odontogenesis Of Dentin-containing Tooth Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Transcription By RNA Polymerase II DNA Binding Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Mesonephric Duct Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Mesonephric Nephron Morphogenesis Ureteric Bud Elongation Pronephric Nephron Tubule Development Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Odontogenesis Animal Organ Morphogenesis Positive Regulation Of Anion Channel Activity Negative Regulation Of RNA Metabolic Process Hepatoblast Differentiation Regulation Of Pronephros Size Positive Regulation Of Monoatomic Anion Transport Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Branch Elongation Involved In Ureteric Bud Branching Mesonephric Duct Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development DNA Replication Positive Regulation Of Enamel Mineralization Anterior/posterior Pattern Specification Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Nephron Morphogenesis Nephric Duct Formation Transepithelial Water Transport Regulation Of RNA Metabolic Process Nephric Duct Development Mesonephric Duct Development Negative Regulation Of Somatic Stem Cell Population Maintenance MRF Binding Positive Regulation Of Tooth Mineralization Inner Cell Mass Cell Differentiation Regulation Of Kidney Size Endodermal Cell Fate Specification Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity
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