RNPS1 and USP4

Number of citations: 0 (PubMedID 27990632)
Data Source: BioGRID (pull down)

		RNPS1	USP4
Name		RNA binding protein with serine rich domain 1	ubiquitin specific peptidase 4
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Exon-exon Junction Complex ASAP Complex	Nucleus Cytoplasm Lysosome Cytosol
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Adenosine Receptor Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome DNA-templated Transcription MRNA Processing RNA Splicing Positive Regulation Of Apoptotic Process Negative Regulation Of MRNA Splicing, Via Spliceosome	Spliceosomal Tri-snRNP Complex Assembly Cytoplasmic Translation Proteolysis Cellular Response To Starvation Protein Deubiquitination Negative Regulation Of Protein Ubiquitination Regulation Of Protein Stability Cellular Response To Nutrient Levels Protein Localization To Cell Surface TORC1 Signaling Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Ub-specific processing proteases
GWAS		No GWAS studies recorded	Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Crohn's disease ( 28067908 ) Glycated hemoglobin levels ( 34059833 28898252 ) High light scatter reticulocyte percentage of red cells ( 27863252 ) Household income (MTAG) ( 31844048 ) Inflammatory bowel disease ( 28067908 23128233 ) Intelligence (MTAG) ( 29326435 ) Lymphocyte count ( 32888494 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Red cell distribution width ( 32888494 ) Refractive error ( 32231278 ) Reticulocyte count ( 27863252 ) Reticulocyte fraction of red cells ( 27863252 32888494 ) Sleep duration (short sleep) ( 30846698 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Ulcerative colitis ( 28067908 25082827 )
Interacting Genes		55 interacting genes: ABI2 CCNL1 CHERP CLK2 CLK3 DVL2 ELOA2 FAM81B GOLGA6L9 GPATCH8 HEXIM2 HOXD4 LUC7L3 NKTR OGT PICK1 PIN1 PNN PRPF38A PSTPIP1 RBMY1F RBMY1J SAP18 SART3 SDCBP2 SRP54 SRRM4 SRSF1 SRSF11 SRSF3 SRSF6 SRSF7 SRSF9 STX11 TBC1D26 TRA2A TRA2B TRIM41 U2AF1 UBQLN4 UPF2 USP4 YTHDC1 YWHAB YWHAG ZBTB14 ZNF165 ZNF286A ZNF345 ZNF394 ZNF41 ZNF473 ZNF490 ZNF660 ZSCAN30	49 interacting genes: AKT1 ANXA7 ASS1 ATP1B1 ATP1B3 BDKRB2 BRAP CDKN1A CIAO2B DLC1 HDAC2 IGKV2D-29 IRF4 LAMA5 LGALS1 MAP3K7 NLK NOLC1 NPC2 PCNA PDK1 PGM1 PLA2G2A PLOD1 PPIA PRPF3 PSAP PSMA6 PSMC5 PSMD11 RB1 RBBP8 RBL1 RBL2 RCC1 RHEB RNPS1 SMAD4 SMN1 TK1 TP53BP2 TRAF2 TRIM21 TRIM54 TRIM55 TRIM63 UBC USP21 USP28
Entrez ID		10921	7375
HPRD ID		07341	04598
Ensembl ID		ENSG00000205937	ENSG00000114316
Uniprot IDs		D3DU92 H3BMS0 Q15287	Q08AK7 Q13107
PDB IDs		4A8X	2Y6E 5CTR
GO Terms Enriched among Interactors		MRNA Processing RNA Splicing Regulation Of RNA Splicing Nuclear Speck MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Nucleus Regulation Of MRNA Processing RNA Processing Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Binding RNA Metabolic Process Regulation Of MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleic Acid Binding Nucleic Acid Metabolic Process Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process MRNA Splice Site Recognition Regulation Of Macromolecule Metabolic Process Spliceosomal Complex Positive Regulation Of RNA Splicing Nucleobase-containing Compound Metabolic Process Exon-exon Junction Complex Negative Regulation Of MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of RNA Splicing Positive Regulation Of MRNA Splicing, Via Spliceosome Protein-RNA Complex Assembly Identical Protein Binding Protein Domain Specific Binding Negative Regulation Of MRNA Metabolic Process Pre-mRNA Binding MRNA Transport ASAP Complex RNA Transport Phosphoserine Residue Binding RS Domain Binding Protein Binding Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Nucleobase-containing Compound Transport Cajal Body	Regulation Of Lipid Kinase Activity Intracellular Signal Transduction Nucleoplasm Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Intracellular Signaling Cassette Macromolecule Metabolic Process Extracellular Exosome PCNA-p21 Complex Regulation Of Kinase Activity Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Response To Stress Nucleus Identical Protein Binding Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Phosphorylation Positive Regulation Of Catalytic Activity TORC1 Signaling Regulation Of Cell Cycle Apoptotic Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Deoxyribonuclease Activity Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cell Cycle Phase Transition Protein-containing Complex Cytoplasm Cytosol Response To External Biotic Stimulus Negative Regulation Of Cell Cycle Signal Transduction Positive Regulation Of Potassium Ion Import Across Plasma Membrane Sulfate Binding Cellular Response To Stress G1/S Transition Of Mitotic Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle TOR Signaling Cell Cycle G1/S Phase Transition Positive Regulation Of Sodium Ion Transport NF-kappaB Binding Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Potassium Ion Import Cellular Response To Chemical Stress Protein Modification Process Negative Regulation Of Cell Cycle Process Epithelial Cell Differentiation DNA-binding Transcription Factor Binding Positive Regulation Of Interleukin-2 Production Cell Differentiation Regulation Of Cell Cycle G1/S Phase Transition