RNPS1 and YTHDC1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		RNPS1	YTHDC1
Name		RNA binding protein with serine rich domain 1	YTH N6-methyladenosine RNA binding protein C1
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Exon-exon Junction Complex ASAP Complex	Nucleus Nucleoplasm Plasma Membrane Nuclear Speck
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding	RNA Binding MRNA Binding Protein Binding N6-methyladenosine-containing RNA Reader Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome DNA-templated Transcription MRNA Processing RNA Splicing Positive Regulation Of Apoptotic Process Negative Regulation Of MRNA Splicing, Via Spliceosome	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome In Utero Embryonic Development MRNA Splice Site Recognition MRNA Processing MRNA Export From Nucleus Spermatogenesis RNA Splicing Dosage Compensation By Inactivation Of X Chromosome Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Splicing, Via Spliceosome Primary Follicle Stage MRNA Alternative Polyadenylation
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Nuclear RNA decay
GWAS		No GWAS studies recorded	Mean corpuscular hemoglobin ( 32888494 ) Obesity-related traits ( 23251661 )
Interacting Genes		55 interacting genes: ABI2 CCNL1 CHERP CLK2 CLK3 DVL2 ELOA2 FAM81B GOLGA6L9 GPATCH8 HEXIM2 HOXD4 LUC7L3 NKTR OGT PICK1 PIN1 PNN PRPF38A PSTPIP1 RBMY1F RBMY1J SAP18 SART3 SDCBP2 SRP54 SRRM4 SRSF1 SRSF11 SRSF3 SRSF6 SRSF7 SRSF9 STX11 TBC1D26 TRA2A TRA2B TRIM41 U2AF1 UBQLN4 UPF2 USP4 YTHDC1 YWHAB YWHAG ZBTB14 ZNF165 ZNF286A ZNF345 ZNF394 ZNF41 ZNF473 ZNF490 ZNF660 ZSCAN30	41 interacting genes: ABL1 ADAMTS4 ANKRD28 CFH CLK1 CLK2 CORO1A DVL3 EDC4 EMD FYN GOLGA2 HNRNPK KHDRBS1 KHDRBS2 KHDRBS3 KRT18 KRTAP10-6 LAMC3 LAMTOR5 LZTS2 PHF19 PICK1 PLG PROSER2 RBMY1A1 RBMY1F RBMY1J RNPS1 SDCBP2 SEPTIN10 SOX13 SRC SRPK1 SRPK2 SRSF1 SRSF2 TRA2A TRA2B TXK VPS51
Entrez ID		10921	91746
HPRD ID		07341	11689
Ensembl ID		ENSG00000205937	ENSG00000083896
Uniprot IDs		D3DU92 H3BMS0 Q15287	J3QR07 Q96MU7
PDB IDs		4A8X	2YUD 4R3H 4R3I 6RT4 6RT5 6RT6 6RT7 6SYZ 6SZ1 6SZ2 6SZ3 6SZL 6SZN 6SZR 6SZT 6SZX 6SZY 6T01 6T02 6T03 6T04 6T05 6T06 6T07 6T08 6T09 6T0A 6T0C 6T0D 6T0O 6T0X 6T0Z 6T10 6T11 6T12 6WE8 6WE9 6WEA 6YKE 6YKI 6YKJ 6YKZ 6YL0 6YL8 6YL9 6YM2 6YM8 6YNI 6YNJ 6YNK 6YNL 6YNM 6YNN 6YNO 6YNP 6YOQ 6ZCM 6ZCN 6ZD9 7L4X 7L4Y 7P87 7P88 7P8A 7P8B 7P8F 7PJ7 7PJ8 7PJ9 7PJA 7PJB 7PJP 7PJQ 7PO6 8K2E 8Q2Q 8Q2R 8Q2S 8Q2T 8Q2U 8Q2V 8Q2W 8Q2X 8Q2Y 8Q31 8Q32 8Q33 8Q35 8Q37 8Q38 8Q39 8Q3A 8Q3G 8Q4M 8Q4N 8Q4P 8Q4Q 8Q4R 8Q4T 8Q4U 8Q4V 8Q4W
GO Terms Enriched among Interactors		MRNA Processing RNA Splicing Regulation Of RNA Splicing Nuclear Speck MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Nucleus Regulation Of MRNA Processing RNA Processing Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Binding RNA Metabolic Process Regulation Of MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleic Acid Binding Nucleic Acid Metabolic Process Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process MRNA Splice Site Recognition Regulation Of Macromolecule Metabolic Process Spliceosomal Complex Positive Regulation Of RNA Splicing Nucleobase-containing Compound Metabolic Process Exon-exon Junction Complex Negative Regulation Of MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of RNA Splicing Positive Regulation Of MRNA Splicing, Via Spliceosome Protein-RNA Complex Assembly Identical Protein Binding Protein Domain Specific Binding Negative Regulation Of MRNA Metabolic Process Pre-mRNA Binding MRNA Transport ASAP Complex RNA Transport Phosphoserine Residue Binding RS Domain Binding Protein Binding Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Nucleobase-containing Compound Transport Cajal Body	Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process MRNA Processing MRNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Splicing Positive Regulation Of RNA Splicing RNA Processing Nucleic Acid Binding Positive Regulation Of MRNA Splicing, Via Spliceosome Protein Domain Specific Binding Non-membrane Spanning Protein Tyrosine Kinase Activity MRNA Binding RNA Binding Spliceosomal Complex RNA Metabolic Process Protein Tyrosine Kinase Activity Macromolecule Metabolic Process SH2 Domain Binding Nucleoplasm Nuclear Speck Nucleic Acid Metabolic Process Regulation Of Macromolecule Biosynthetic Process Protein Phosphorylation Positive Regulation Of Gene Expression Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Protein Kinase Activity Positive Regulation Of MRNA Metabolic Process Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Gene Expression Phosphorylation Regulation Of RNA Metabolic Process Identical Protein Binding Ephrin Receptor Binding Nucleus Regulation Of Primary Metabolic Process Nucleolus Fc-gamma Receptor Signaling Pathway Kinase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome T Cell Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process RNA Splicing, Via Transesterification Reactions Negative Regulation Of Actin Nucleation Activated T Cell Proliferation Ephrin Receptor Signaling Pathway