LINC00624 and MCCC1

Number of citations of the paper that reports this interaction (PubMedID 36252997)
50

Data Source:
BioGRID (unspecified method)

		LINC00624	MCCC1
Description		long intergenic non-protein coding RNA 624	methylcrotonyl-CoA carboxylase subunit 1
Image		No pdb structure
GO Annotations	Cellular Component		Mitochondrion Mitochondrial Matrix Cytosol Methylcrotonoyl-CoA Carboxylase Complex
	Molecular Function		Nucleotide Binding Biotin Carboxylase Activity Methylcrotonoyl-CoA Carboxylase Activity Protein Binding ATP Binding Biotin Binding Ligase Activity Metal Ion Binding
	Biological Process		L-leucine Catabolic Process Biotin Metabolic Process Branched-chain Amino Acid Catabolic Process
Pathways			Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency Branched-chain amino acid catabolism 3-Methylcrotonyl-CoA carboxylase deficiency
Drugs			Biotin
Diseases			3-Methylcrotonylglycinuria; 3-Methylcrotonyl-CoA carboxylase deficiency
GWAS		Body mass index and systolic blood pressure (bivariate analysis) ( 33539483) End-stage kidney disease ( 31178898) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 31562340) Systolic blood pressure and diastolic blood pressure (bivariate analysis) ( 33539483) Waist circumference adjusted for body mass index ( 28552196)	Fasting insulin ( 34074324) Lung function (FVC) ( 30175238) Lymphocyte count ( 32888494) Parkinson's disease ( 21292315 21738487 25064009 27182965 28011712 28892059 32201043 32310270) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Serum metabolite levels ( 33031748) Subjective response to lithium treatment ( 26503763)
Interacting Genes		38 interacting genes: ACTA1 ACTC1 ADAR ALB CCT2 CCT4 CPNE3 DDX42 DDX5 EIF2AK2 FUBP3 G6PD H2BC18 HDAC6 HNRNPL HNRNPM HNRNPU HRNR ILF3 MCCC1 MCCC2 NONO PARP1 PTBP1 PTBP2 PTBP3 SERBP1 SFPQ SND1 SRRT STAU1 STAU2 TRIM28 TUBA1B TUBA1C UBAP2L YBX3 ZNF354C	1 interacting genes: LINC00624
Entrez ID		100289211	56922
HPRD ID			01951
Ensembl ID		ENSG00000278811	ENSG00000078070
Uniprot IDs			A0A0S2Z693 E9PHF7 Q96RQ3
PDB IDs			2EJM 8J4Z 8J78 8J7D 8J99 8JAK 8JAW 8JXL 8JXM 8JXN 8K2V 8XL6 8XL7 8XL8
Enriched GO Terms of Interacting Partners?		RNA Binding RNA Localization Nucleic Acid Binding Double-stranded RNA Binding MRNA Processing MRNA Binding Negative Regulation Of Macromolecule Biosynthetic Process MRNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Viral Genome Replication Negative Regulation Of Metabolic Process Dendritic Transport Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression RNA Splicing Regulation Of Viral Life Cycle RNA Processing Cytoskeleton-dependent Intracellular Transport Alternative MRNA Splicing, Via Spliceosome Regulation Of Viral Process RNA Metabolic Process Cell Body Nucleus Axo-dendritic Transport Paraspeckles Regulation Of Macromolecule Biosynthetic Process Intracellular MRNA Localization Extracellular Exosome Regulation Of RNA Splicing Methylcrotonoyl-CoA Carboxylase Complex Methylcrotonoyl-CoA Carboxylase Activity Regulation Of Telomere Maintenance Via Telomere Lengthening Pre-mRNA Binding Cytoplasm Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Dendritic Transport Of Messenger Ribonucleoprotein Complex Anterograde Dendritic Transport Of Messenger Ribonucleoprotein Complex Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Cellular Response To Chemical Stress Negative Regulation Of RNA Splicing Negative Regulation Of RNA Metabolic Process Regulatory NcRNA-mediated Gene Silencing Transport Along Microtubule Binding Of Sperm To Zona Pellucida Mesenchyme Migration ScaRNA Localization To Cajal Body
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