SERPINA5 and SEMG2

Number of citations of the paper that reports this interaction (PMID 8665956)
6

Data Source:
HPRD (in vitro)

		SERPINA5	SEMG2
Gene Name		serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	semenogelin II
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Acrosomal Membrane Extracellular Region Extracellular Space External Side Of Plasma Membrane Membrane Platelet Alpha Granule Platelet Dense Tubular Network Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-PLAT Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Protein Complex Extracellular Vesicular Exosome Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-coagulation Factor XI Complex	Extracellular Space Nucleus Secretory Granule Extracellular Vesicular Exosome
	Molecular Function	Retinoic Acid Binding Protease Binding Serine-type Endopeptidase Inhibitor Activity Glycosaminoglycan Binding Heparin Binding Phosphatidylcholine Binding Acrosin Binding	Structural Molecule Activity
	Biological Process	Lipid Transport Spermatogenesis Fusion Of Sperm To Egg Plasma Membrane Blood Coagulation Negative Regulation Of Endopeptidase Activity	Sexual Reproduction
Pathways		Common Pathway Intrinsic Pathway Formation of Fibrin Clot (Clotting Cascade)
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: ACR COPS6 F10 F11 F2 FGA FGB FGG HRSP12 KLK1 KLK2 KLK3 KLKB1 PIAS4 PLAT PLAU PROC RCHY1 SEMG2 THBD	7 interactors: KLK2 KLK3 PRKAR2A PRKCA SEMG1 SERPINA5 TGM1
Entrez ID		5104	6407
HPRD ID		03503	01642
Ensembl ID		ENSG00000188488	ENSG00000124157
Uniprot IDs		B3KTV6 B4DDH1 B4DPC7 P05154	Q02383
PDB IDs		1LQ8 1PAI 2HI9 2OL2 2PAI 3DY0
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Blood Coagulation Blood Coagulation Hemostasis Regulation Of Wound Healing Regulation Of Body Fluid Levels Wound Healing Response To Wounding Regulation Of Fibrinolysis Blood Coagulation, Intrinsic Pathway Plasminogen Activation Fibrinolysis Proteolysis Protein Activation Cascade Positive Regulation Of Fibrinolysis Positive Regulation Of Heterotypic Cell-cell Adhesion Peptidyl-glutamic Acid Carboxylation Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Endothelial Cell Apoptotic Process Protein Metabolic Process Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Zymogen Activation Factor XII Activation Positive Regulation Of Vasoconstriction Regulation Of Substrate Adhesion-dependent Cell Spreading Response To Stress Regulation Of Endothelial Cell Apoptotic Process Platelet Aggregation Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Vasoconstriction Platelet Activation Positive Regulation Of Exocytosis Regulation Of Cell-substrate Adhesion Platelet Degranulation Negative Regulation Of Fibrinolysis Acute Inflammatory Response Plasma Kallikrein-kinin Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Peptide Hormone Secretion Protein Processing Positive Regulation Of Peptide Secretion Extracellular Matrix Disassembly Protein Polymerization Positive Regulation Of Hormone Secretion Negative Regulation Of Platelet Activation Response To Calcium Ion	Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Positive Regulation Of Dense Core Granule Biogenesis Extracellular Matrix Disassembly Positive Regulation Of Inflammatory Response Regulation Of Blood Coagulation Factor XII Activation Cell Envelope Organization Histone H3-T6 Phosphorylation Regulation Of Wound Healing Negative Regulation Of Protein Serine/threonine Kinase Activity Energy Reserve Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Catalytic Activity Positive Regulation Of Fibrinolysis Negative Regulation Of Cellular Protein Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Insulin Secretion Negative Regulation Of Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Protein Kinase Activity Regulation Of Peptide Hormone Secretion Regulation Of Angiogenesis Neurotrophin Signaling Pathway Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Negative Regulation Of CAMP-dependent Protein Kinase Activity Plasminogen Activation Regulation Of Hormone Secretion Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Inflammatory Response Plasma Kallikrein-kinin Cascade Energy Derivation By Oxidation Of Organic Compounds Negative Regulation Of Glucose Import
Tagcloud ?		across agr2 assigned differently effector endocrine ergs estradiol exploitable greb1 interpretation menstrual mirroring pdzk1 pgr premenopausal progesterone rankl responsiveness rhythm runx1 tff1 tumours varies w1 w2 w3 windows
Tagcloud (Difference) ?		across agr2 assigned differently effector endocrine ergs estradiol exploitable greb1 interpretation menstrual mirroring pdzk1 pgr premenopausal progesterone rankl responsiveness rhythm runx1 tff1 tumours varies w1 w2 w3 windows
Tagcloud (Intersection) ?