SERPINA5 and THBD

Number of citations of the paper that reports this interaction (PMID 12878585)
8

Data Source:
HPRD (in vitro)

		SERPINA5	THBD
Gene Name		serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	thrombomodulin
Image
Gene Ontology Annotations	Cellular Component	Acrosomal Membrane Extracellular Region Extracellular Space External Side Of Plasma Membrane Membrane Platelet Alpha Granule Platelet Dense Tubular Network Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-PLAT Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Protein Complex Extracellular Vesicular Exosome Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-coagulation Factor XI Complex	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface
	Molecular Function	Retinoic Acid Binding Protease Binding Serine-type Endopeptidase Inhibitor Activity Glycosaminoglycan Binding Heparin Binding Phosphatidylcholine Binding Acrosin Binding	Receptor Activity Transmembrane Signaling Receptor Activity Calcium Ion Binding Protein Binding
	Biological Process	Lipid Transport Spermatogenesis Fusion Of Sperm To Egg Plasma Membrane Blood Coagulation Negative Regulation Of Endopeptidase Activity	Signal Transduction Female Pregnancy Blood Coagulation Response To X-ray Negative Regulation Of Platelet Activation Negative Regulation Of Blood Coagulation Response To Lipopolysaccharide Leukocyte Migration Response To CAMP Negative Regulation Of Fibrinolysis
Pathways		Common Pathway Intrinsic Pathway Formation of Fibrin Clot (Clotting Cascade)	Common Pathway Formation of Fibrin Clot (Clotting Cascade) Cell surface interactions at the vascular wall
Drugs			Drotrecogin alfa Ibuprofen
Diseases
GWAS
Protein-Protein Interactions		20 interactors: ACR COPS6 F10 F11 F2 FGA FGB FGG HRSP12 KLK1 KLK2 KLK3 KLKB1 PIAS4 PLAT PLAU PROC RCHY1 SEMG2 THBD	5 interactors: F2 PF4 PROC PSENEN SERPINA5
Entrez ID		5104	7056
HPRD ID		03503	01764
Ensembl ID		ENSG00000188488	ENSG00000178726
Uniprot IDs		B3KTV6 B4DDH1 B4DPC7 P05154	P07204
PDB IDs		1LQ8 1PAI 2HI9 2OL2 2PAI 3DY0	1ADX 1DQB 1DX5 1EGT 1FGD 1FGE 1HLT 1TMR 1ZAQ 2ADX 3GIS
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Blood Coagulation Blood Coagulation Hemostasis Regulation Of Wound Healing Regulation Of Body Fluid Levels Wound Healing Response To Wounding Regulation Of Fibrinolysis Blood Coagulation, Intrinsic Pathway Plasminogen Activation Fibrinolysis Proteolysis Protein Activation Cascade Positive Regulation Of Fibrinolysis Positive Regulation Of Heterotypic Cell-cell Adhesion Peptidyl-glutamic Acid Carboxylation Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Endothelial Cell Apoptotic Process Protein Metabolic Process Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Zymogen Activation Factor XII Activation Positive Regulation Of Vasoconstriction Regulation Of Substrate Adhesion-dependent Cell Spreading Response To Stress Regulation Of Endothelial Cell Apoptotic Process Platelet Aggregation Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Vasoconstriction Platelet Activation Positive Regulation Of Exocytosis Regulation Of Cell-substrate Adhesion Platelet Degranulation Negative Regulation Of Fibrinolysis Acute Inflammatory Response Plasma Kallikrein-kinin Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Peptide Hormone Secretion Protein Processing Positive Regulation Of Peptide Secretion Extracellular Matrix Disassembly Protein Polymerization Positive Regulation Of Hormone Secretion Negative Regulation Of Platelet Activation Response To Calcium Ion	Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Peptidyl-glutamic Acid Carboxylation Response To Wounding Leukocyte Migration Locomotion Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Movement Of Cell Or Subcellular Component Regulation Of Blood Coagulation Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Wound Healing Cell Migration Cell Motility Negative Regulation Of Cytolysis Platelet Activation Post-translational Protein Modification Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Response To Stress Negative Regulation Of Fibrinolysis Negative Regulation Of Proteolysis Regulation Of Apoptotic Process Negative Regulation Of Protein Processing Proteolysis Positive Regulation Of Macrophage Differentiation Amyloid Precursor Protein Catabolic Process Regulation Of Cell Death Regulation Of Protein Processing Regulation Of Fibrinolysis Positive Regulation Of CAMP-mediated Signaling Inflammatory Response Blood Coagulation, Intrinsic Pathway Negative Regulation Of Astrocyte Differentiation Fusion Of Sperm To Egg Plasma Membrane Membrane Protein Intracellular Domain Proteolysis Negative Regulation Of Platelet Activation Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Megakaryocyte Differentiation Plasma Membrane Fusion Membrane Protein Ectodomain Proteolysis Amyloid Precursor Protein Metabolic Process Regulation Of CAMP-mediated Signaling Notch Receptor Processing Response To Stimulus Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Tagcloud ?		across agr2 assigned differently effector endocrine ergs estradiol exploitable greb1 interpretation menstrual mirroring pdzk1 pgr premenopausal progesterone rankl responsiveness rhythm runx1 tff1 tumours varies w1 w2 w3 windows	acat acyltransferase alox5ap arachidonate ath atherosclerotic cbs cysthathionenine deceased gathered genomelab gexp hcats irs1 lcat ldlr lecithin lipoxygenase lpl malaysian metallopeptidase methylenetetrahydrofolate mmp9 mortem mthfr ncat predetermined tgfbr2 thrombomodulin
Tagcloud (Difference) ?		across agr2 assigned differently effector endocrine ergs estradiol exploitable greb1 interpretation menstrual mirroring pdzk1 pgr premenopausal progesterone rankl responsiveness rhythm runx1 tff1 tumours varies w1 w2 w3 windows	acat acyltransferase alox5ap arachidonate ath atherosclerotic cbs cysthathionenine deceased gathered genomelab gexp hcats irs1 lcat ldlr lecithin lipoxygenase lpl malaysian metallopeptidase methylenetetrahydrofolate mmp9 mortem mthfr ncat predetermined tgfbr2 thrombomodulin
Tagcloud (Intersection) ?