SERPINA5 and KLK1

Number of citations of the paper that reports this interaction (PMID 9368023)
8

Data Source:
HPRD (in vitro)

		SERPINA5	KLK1
Gene Name		serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	kallikrein 1
Image
Gene Ontology Annotations	Cellular Component	Acrosomal Membrane Extracellular Region Extracellular Space External Side Of Plasma Membrane Membrane Platelet Alpha Granule Platelet Dense Tubular Network Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-PLAT Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Protein Complex Extracellular Vesicular Exosome Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-coagulation Factor XI Complex	Nucleus Extracellular Vesicular Exosome
	Molecular Function	Retinoic Acid Binding Protease Binding Serine-type Endopeptidase Inhibitor Activity Glycosaminoglycan Binding Heparin Binding Phosphatidylcholine Binding Acrosin Binding	Serine-type Endopeptidase Activity
	Biological Process	Lipid Transport Spermatogenesis Fusion Of Sperm To Egg Plasma Membrane Blood Coagulation Negative Regulation Of Endopeptidase Activity	Proteolysis
Pathways		Common Pathway Intrinsic Pathway Formation of Fibrin Clot (Clotting Cascade)	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs			Aprotinin
Diseases
GWAS
Protein-Protein Interactions		20 interactors: ACR COPS6 F10 F11 F2 FGA FGB FGG HRSP12 KLK1 KLK2 KLK3 KLKB1 PIAS4 PLAT PLAU PROC RCHY1 SEMG2 THBD	3 interactors: KNG1 SERPINA4 SERPINA5
Entrez ID		5104	3816
HPRD ID		03503	01003
Ensembl ID		ENSG00000188488	ENSG00000167748
Uniprot IDs		B3KTV6 B4DDH1 B4DPC7 P05154	F8WAM8 P06870
PDB IDs		1LQ8 1PAI 2HI9 2OL2 2PAI 3DY0	1SPJ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Blood Coagulation Blood Coagulation Hemostasis Regulation Of Wound Healing Regulation Of Body Fluid Levels Wound Healing Response To Wounding Regulation Of Fibrinolysis Blood Coagulation, Intrinsic Pathway Plasminogen Activation Fibrinolysis Proteolysis Protein Activation Cascade Positive Regulation Of Fibrinolysis Positive Regulation Of Heterotypic Cell-cell Adhesion Peptidyl-glutamic Acid Carboxylation Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Endothelial Cell Apoptotic Process Protein Metabolic Process Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Zymogen Activation Factor XII Activation Positive Regulation Of Vasoconstriction Regulation Of Substrate Adhesion-dependent Cell Spreading Response To Stress Regulation Of Endothelial Cell Apoptotic Process Platelet Aggregation Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Vasoconstriction Platelet Activation Positive Regulation Of Exocytosis Regulation Of Cell-substrate Adhesion Platelet Degranulation Negative Regulation Of Fibrinolysis Acute Inflammatory Response Plasma Kallikrein-kinin Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Peptide Hormone Secretion Protein Processing Positive Regulation Of Peptide Secretion Extracellular Matrix Disassembly Protein Polymerization Positive Regulation Of Hormone Secretion Negative Regulation Of Platelet Activation Response To Calcium Ion	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Regulation Of Proteolysis Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Blood Coagulation Hemostasis Regulation Of Catalytic Activity Positive Regulation Of Renal Sodium Excretion Regulation Of Body Fluid Levels Wound Healing Positive Regulation Of Urine Volume Blood Coagulation, Intrinsic Pathway Fusion Of Sperm To Egg Plasma Membrane Plasma Membrane Fusion Response To Wounding Regulation Of Renal Sodium Excretion Regulation Of Excretion Vasodilation Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Smooth Muscle Contraction Negative Regulation Of Wound Healing Platelet Degranulation Regulation Of Blood Vessel Size Regulation Of Tube Size Renal System Process Regulation Of Blood Coagulation Membrane Fusion Regulation Of Wound Healing Single Fertilization Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Ion Homeostasis Protein Activation Cascade Fertilization Cytosolic Calcium Ion Homeostasis Platelet Activation
Tagcloud ?		across agr2 assigned differently effector endocrine ergs estradiol exploitable greb1 interpretation menstrual mirroring pdzk1 pgr premenopausal progesterone rankl responsiveness rhythm runx1 tff1 tumours varies w1 w2 w3 windows	b2 bradykinin cancers diverse du145 emanating endometrial enzymic exhibit expressed implicated kallikrein kinin lncap member members organs particular prostate proteases range reproductive serine structurally tissue tumorigenesis uterus varying
Tagcloud (Difference) ?		across agr2 assigned differently effector endocrine ergs estradiol exploitable greb1 interpretation menstrual mirroring pdzk1 pgr premenopausal progesterone rankl responsiveness rhythm runx1 tff1 tumours varies w1 w2 w3 windows	b2 bradykinin cancers diverse du145 emanating endometrial enzymic exhibit expressed implicated kallikrein kinin lncap member members organs particular prostate proteases range reproductive serine structurally tissue tumorigenesis uterus varying
Tagcloud (Intersection) ?