SERPINA5 and FGG

Number of citations of the paper that reports this interaction (PMID 8384496)
0

Data Source:
HPRD (in vitro)

		SERPINA5	FGG
Gene Name		serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5	fibrinogen gamma chain
Image
Gene Ontology Annotations	Cellular Component	Acrosomal Membrane Extracellular Region Extracellular Space External Side Of Plasma Membrane Membrane Platelet Alpha Granule Platelet Dense Tubular Network Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-PLAT Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Protein Complex Extracellular Vesicular Exosome Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-coagulation Factor XI Complex	Extracellular Region Fibrinogen Complex Extracellular Space Plasma Membrane Cell Cortex External Side Of Plasma Membrane Cell Surface Platelet Alpha Granule Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Retinoic Acid Binding Protease Binding Serine-type Endopeptidase Inhibitor Activity Glycosaminoglycan Binding Heparin Binding Phosphatidylcholine Binding Acrosin Binding	Receptor Binding Structural Molecule Activity Protein Binding, Bridging Metal Ion Binding Cell Adhesion Molecule Binding
	Biological Process	Lipid Transport Spermatogenesis Fusion Of Sperm To Egg Plasma Membrane Blood Coagulation Negative Regulation Of Endopeptidase Activity	Platelet Degranulation Cell-matrix Adhesion Signal Transduction Blood Coagulation Platelet Activation Extracellular Matrix Organization Positive Regulation Of Heterotypic Cell-cell Adhesion Cellular Protein Complex Assembly Positive Regulation Of Vasoconstriction Positive Regulation Of Exocytosis Positive Regulation Of Protein Secretion Protein Polymerization Response To Calcium Ion Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Common Pathway Intrinsic Pathway Formation of Fibrin Clot (Clotting Cascade)	p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet degranulation Platelet Aggregation (Plug Formation) Formation of Fibrin Clot (Clotting Cascade) Common Pathway Response to elevated platelet cytosolic Ca2+ Integrin cell surface interactions Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS			D-dimer levels ( 21502573) Fibrinogen ( 20031577 21757653) Venous thromboembolism ( 21980494 23650146)
Protein-Protein Interactions		20 interactors: ACR COPS6 F10 F11 F2 FGA FGB FGG HRSP12 KLK1 KLK2 KLK3 KLKB1 PIAS4 PLAT PLAU PROC RCHY1 SEMG2 THBD	10 interactors: F13A1 F13B FGA FGB ICAM1 ITGAM ITGB3 SERPINA5 VKORC1 VTN
Entrez ID		5104	2266
HPRD ID		03503	00621
Ensembl ID		ENSG00000188488	ENSG00000171557
Uniprot IDs		B3KTV6 B4DDH1 B4DPC7 P05154	P02679
PDB IDs		1LQ8 1PAI 2HI9 2OL2 2PAI 3DY0	1DUG 1FIB 1FIC 1FID 1FZA 1FZB 1FZC 1FZE 1FZF 1FZG 1LT9 1LTJ 1N86 1N8E 1RE3 1RE4 1RF0 1RF1 2A45 2FFD 2FIB 2H43 2HLO 2HOD 2HPC 2HWL 2OYH 2OYI 2Q9I 2VDO 2VDP 2VDQ 2VDR 2VR3 2XNX 2XNY 2Y7L 2Z4E 3BVH 3E1I 3FIB 3GHG 3H32 3HUS
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Blood Coagulation Blood Coagulation Hemostasis Regulation Of Wound Healing Regulation Of Body Fluid Levels Wound Healing Response To Wounding Regulation Of Fibrinolysis Blood Coagulation, Intrinsic Pathway Plasminogen Activation Fibrinolysis Proteolysis Protein Activation Cascade Positive Regulation Of Fibrinolysis Positive Regulation Of Heterotypic Cell-cell Adhesion Peptidyl-glutamic Acid Carboxylation Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Endothelial Cell Apoptotic Process Protein Metabolic Process Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Zymogen Activation Factor XII Activation Positive Regulation Of Vasoconstriction Regulation Of Substrate Adhesion-dependent Cell Spreading Response To Stress Regulation Of Endothelial Cell Apoptotic Process Platelet Aggregation Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Vasoconstriction Platelet Activation Positive Regulation Of Exocytosis Regulation Of Cell-substrate Adhesion Platelet Degranulation Negative Regulation Of Fibrinolysis Acute Inflammatory Response Plasma Kallikrein-kinin Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Peptide Hormone Secretion Protein Processing Positive Regulation Of Peptide Secretion Extracellular Matrix Disassembly Protein Polymerization Positive Regulation Of Hormone Secretion Negative Regulation Of Platelet Activation Response To Calcium Ion	Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Extracellular Matrix Organization Extracellular Structure Organization Response To Stress Platelet Degranulation Cell Activation Homotypic Cell-cell Adhesion Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Vasoconstriction Regulation Of Endothelial Cell Apoptotic Process Platelet Aggregation Cell-matrix Adhesion Platelet Activation Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Single Organismal Cell-cell Adhesion Cell-substrate Adhesion Regulation Of Vasoconstriction Cell Adhesion Positive Regulation Of Heterotypic Cell-cell Adhesion Exocytosis Innate Immune Response Cell Adhesion Mediated By Integrin Positive Regulation Of Phosphorylation Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Stimulus Positive Regulation Of Peptidyl-tyrosine Phosphorylation Secretion By Cell Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell-substrate Adhesion Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Signal Transduction Regulation Of Cell Adhesion Immune System Process Secretion Immune Response Leukocyte Migration Regulation Of Phosphorylation Defense Response
Tagcloud ?		across agr2 assigned differently effector endocrine ergs estradiol exploitable greb1 interpretation menstrual mirroring pdzk1 pgr premenopausal progesterone rankl responsiveness rhythm runx1 tff1 tumours varies w1 w2 w3 windows	apo appeared approximately chain comparative conduct de differentially disappear exist expressions fibrinogen fragmented full h4 heavy inter iti iv kda lc matched pd people proteomic size spots trypsin validate
Tagcloud (Difference) ?		across agr2 assigned differently effector endocrine ergs estradiol exploitable greb1 interpretation menstrual mirroring pdzk1 pgr premenopausal progesterone rankl responsiveness rhythm runx1 tff1 tumours varies w1 w2 w3 windows	apo appeared approximately chain comparative conduct de differentially disappear exist expressions fibrinogen fragmented full h4 heavy inter iti iv kda lc matched pd people proteomic size spots trypsin validate
Tagcloud (Intersection) ?