SERPINA5 and KLK3

Number of citations of the paper that reports this interaction (PubMedID 8732755)
71

Data Source:
HPRD (in vitro)

		SERPINA5	KLK3
Description		serpin family A member 5	kallikrein related peptidase 3
Image
GO Annotations	Cellular Component	Acrosomal Membrane Extracellular Region Extracellular Space External Side Of Plasma Membrane Membrane Extracellular Matrix Platelet Alpha Granule Platelet Dense Tubular Network Protein-containing Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-PLAT Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Extracellular Exosome Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-coagulation Factor XI Complex	Extracellular Region Extracellular Space Nucleus Secretory Granule Protein-containing Complex Extracellular Exosome
	Molecular Function	Retinoic Acid Binding Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Glycosaminoglycan Binding Heparin Binding Peptidase Inhibitor Activity Phosphatidylcholine Binding Acrosin Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides
	Biological Process	Lipid Transport Spermatogenesis Single Fertilization Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Seminal Clot Liquefaction	Positive Regulation Of Antibacterial Peptide Production Regulation Of Systemic Arterial Blood Pressure Proteolysis Negative Regulation Of Angiogenesis Zymogen Activation
Pathways		Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Drugs		Urokinase Drotrecogin alfa Tifuvirtide PPL-100	Mifepristone Metribolone Cyproterone acetate Gallium Ga-68 gozetotide Lutetium Lu-177 vipivotide tetraxetan
Diseases
GWAS		Blood protein levels ( 30072576) Serum albumin levels ( 29403010) Serum total protein levels ( 29403010)	Celiac disease ( 23936387) Elevated serum prostate-specific antigen levels in healthy men ( 28471803) PCA3 expression level ( 23555189) Prostate cancer ( 18264097 24753544 26034056 31562322 34012061) Prostate cancer (early onset) ( 24740154) Prostate cancer aggressiveness ( 25939597) Prostate-specific antigen levels ( 23269536 24919509 25434496 28139693) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Serum prostate-specific antigen levels ( 21160077)
Interacting Genes		22 interacting genes: ACR CBL COPS6 EPS8 F10 F11 F2 FGA FGB FGG KLK1 KLK2 KLK3 KLKB1 PIAS4 PLAT PLAU PROC RCHY1 RIDA SEMG2 THBD	14 interacting genes: A2M ALB EPOR FN1 IGFBP3 PLG PTHLH PZP SEMG1 SEMG2 SERPINA1 SERPINA3 SERPINA5 SLPI
Entrez ID		5104	354
HPRD ID		03503	01461
Ensembl ID		ENSG00000188488	ENSG00000142515
Uniprot IDs		B4DDH1 P05154	P07288 Q546G3
PDB IDs		1LQ8 2HI9 2OL2 3DY0	2ZCH 2ZCK 2ZCL 3QUM 9F1I
Enriched GO Terms of Interacting Partners?		Zymogen Activation Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Blood Coagulation Hemostasis Negative Regulation Of Wound Healing Regulation Of Blood Coagulation Plasminogen Activation Regulation Of Hemostasis Serine-type Peptidase Activity Serine-type Endopeptidase Activity Fibrinolysis Protein Processing Regulation Of Wound Healing Proteolysis Regulation Of Response To Wounding Regulation Of Body Fluid Levels Regulation Of Fibrinolysis Protein Maturation Peptidase Activity Extracellular Space Protein Metabolic Process Regulation Of Biological Quality Negative Regulation Of Fibrinolysis Extracellular Exosome Extracellular Region Negative Regulation Of Multicellular Organismal Process Macromolecule Metabolic Process Protein Activation Cascade Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Fibrinogen Complex Blood Coagulation, Fibrin Clot Formation Hydrolase Activity External Side Of Plasma Membrane Positive Regulation Of Heterotypic Cell-cell Adhesion Regulation Of Protein Maturation Positive Regulation Of Wound Healing Blood Coagulation, Common Pathway Platelet Activation Platelet Alpha Granule Negative Regulation Of Protein Maturation Positive Regulation Of Vasoconstriction Regulation Of Proteolysis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Secretory Granule Positive Regulation Of Fibrinolysis Regulation Of Protein Metabolic Process	Extracellular Region Extracellular Space Protease Binding Platelet Alpha Granule Lumen Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity Extracellular Matrix Blood Microparticle Extracellular Exosome Coagulation Negative Regulation Of Flagellated Sperm Motility Positive Regulation Of Serine-type Endopeptidase Activity Acute-phase Response Endopeptidase Inhibitor Activity Acute Inflammatory Response Antibacterial Humoral Response Positive Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Reproductive Process Endoplasmic Reticulum Lumen Regulation Of Flagellated Sperm Motility Regulation Of Endopeptidase Activity Sperm Capacitation Antimicrobial Humoral Response Regulation Of Cilium Movement Defense Response Biological Process Involved In Interaction With Symbiont Developmental Process Involved In Reproduction Growth Factor Binding Erythropoietin Receptor Activity Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-coagulation Factor XI Complex Protein C Inhibitor-PLAT Complex Regulation Of Microtubule-based Movement Regulation Of Cell Motility Humoral Immune Response Regulation Of Locomotion Negative Regulation Of Reproductive Process Negative Regulation Of Complement Activation, Lectin Pathway Enterobactin Binding Exogenous Protein Binding Cellular Response To Calcium Ion Starvation Seminal Clot Liquefaction
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?