PERP and MAL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PERP	MAL
Description		p53 apoptosis effector related to PMP22	mal, T cell differentiation protein (MAL blood group)
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Golgi Apparatus Plasma Membrane Cell-cell Junction Membrane Desmosome Anchoring Junction	Endoplasmic Reticulum Plasma Membrane Membrane Apical Plasma Membrane Schmidt-Lanterman Incisure Plasma Membrane Raft Membrane Raft Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane
	Molecular Function	Protein Binding	Protein Binding Lipid Binding Peptidase Activator Activity Involved In Apoptotic Process Structural Constituent Of Myelin Sheath
	Biological Process	Tissue Homeostasis Desmosome Organization Apoptotic Process Cell Adhesion Notch Signaling Pathway Heterotypic Cell-cell Adhesion Positive Regulation Of Proteolysis Mammary Gland Duct Morphogenesis Positive Regulation Of T Cell Apoptotic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Neutrophil Chemotaxis Amelogenesis Cell-cell Adhesion	Membrane Raft Polarization Protein Localization To Paranode Region Of Axon Apoptotic Process Central Nervous System Development Central Nervous System Myelination Cell Differentiation Myelination Apical Protein Localization Protein Insertion Into Plasma Membrane Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain Formation of the cornified envelope
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Bulimia nervosa ( 23568457) Systemic lupus erythematosus ( 26663301)
Interacting Genes		2 interacting genes: ABHD16A MAL	81 interacting genes: AMHR2 AQP6 BCL2L13 BTN2A1 CALN1 CD300LG CD3G CD40 CD53 CD69 CLDN14 CLDN20 CLDN7 CLDN9 CLEC4C CLSTN3 CPLX4 CREB3L1 CXADR DAGLA EDA EMP1 EVI2A FAM209A FCRL2 FIBCD1 FNDC9 GJA8 GJB1 GPR152 GRAMD1A GSG1L HIBADH IL10RA IL20RB JAML KCNA1 KCNA10 KCNMB4 KLRC1 LDLRAD1 LMAN2L LMNA LRRC25 LRTM1 LSMEM1 MC4R MS4A4A MYD88 NCAPH2 NKAIN4 NPDC1 OPRM1 PERP PLA2G10 PRRT1 PTPRN RAMP1 SDC4 SGCB SHISA3 SHISA4 SLC10A1 SLC35H1 SMIM3 SPINT1 STX1A SYNDIG1 TEX29 TIGIT TM4SF18 TMEM106C TMEM174 TMEM207 TMEM213 TMEM248 TMEM30A TMEM52B TNFSF14 TSPO2 USP7
Entrez ID		64065	4118
HPRD ID		17836	01789
Ensembl ID		ENSG00000112378	ENSG00000172005
Uniprot IDs		Q96FX8	P21145
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Phosphatidylserine Catabolic Process Prostaglandin Catabolic Process Membrane Raft Polarization Protein Localization To Paranode Region Of Axon Peptidase Activator Activity Involved In Apoptotic Process Monoacylglycerol Catabolic Process Protein Localization To Axon Schmidt-Lanterman Incisure Membrane Raft Distribution Membrane Raft Localization Structural Constituent Of Myelin Sheath Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Central Nervous System Myelination Monoacylglycerol Lipase Activity Apical Protein Localization Phosphatidylserine Metabolic Process Phosphatidylcholine Lysophospholipase Activity Glycerophospholipid Catabolic Process Phospholipase Activity Acylglycerol Catabolic Process Membrane Raft Organization Modified Amino Acid Catabolic Process Plasma Membrane Raft Phospholipid Catabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Protein Insertion Into Membrane Fatty Acid Derivative Metabolic Process Acylglycerol Metabolic Process Neutral Lipid Metabolic Process Myelination Axon Ensheathment Central Nervous System Development Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Modified Amino Acid Metabolic Process Organophosphate Catabolic Process	Membrane Plasma Membrane Protein Binding Gamma-delta T Cell Activation Anchoring Junction Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Postsynaptic Density Membrane Cell-cell Junction Organization Bicellular Tight Junction Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell Junction Organization Bicellular Tight Junction Assembly Tight Junction Assembly Tight Junction Organization Structural Molecule Activity Cell-cell Junction Assembly Leukocyte Activation
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