MAL and HIBADH

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MAL	HIBADH
Description		mal, T cell differentiation protein (MAL blood group)	3-hydroxyisobutyrate dehydrogenase
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Membrane Apical Plasma Membrane Schmidt-Lanterman Incisure Plasma Membrane Raft Membrane Raft Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane	Mitochondrion Mitochondrial Matrix
	Molecular Function	Protein Binding Lipid Binding Peptidase Activator Activity Involved In Apoptotic Process Structural Constituent Of Myelin Sheath	Protein Binding 3-hydroxyisobutyrate Dehydrogenase Activity Oxidoreductase Activity NADP Binding NAD Binding
	Biological Process	Membrane Raft Polarization Protein Localization To Paranode Region Of Axon Apoptotic Process Central Nervous System Development Central Nervous System Myelination Cell Differentiation Myelination Apical Protein Localization Protein Insertion Into Plasma Membrane Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	L-valine Catabolic Process Branched-chain Amino Acid Catabolic Process
Pathways			Branched-chain amino acid catabolism
Drugs			NADH
Diseases
GWAS			Alcohol consumption (drinks per week) ( 30643258) Asthma ( 31959851) Diastolic blood pressure ( 27841878) General risk tolerance (MTAG) ( 30643258) Kidney stones ( 31729369) Lead levels in blood ( 25820613) Pulse pressure ( 27841878) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Systolic blood pressure ( 27841878)
Interacting Genes		81 interacting genes: AMHR2 AQP6 BCL2L13 BTN2A1 CALN1 CD300LG CD3G CD40 CD53 CD69 CLDN14 CLDN20 CLDN7 CLDN9 CLEC4C CLSTN3 CPLX4 CREB3L1 CXADR DAGLA EDA EMP1 EVI2A FAM209A FCRL2 FIBCD1 FNDC9 GJA8 GJB1 GPR152 GRAMD1A GSG1L HIBADH IL10RA IL20RB JAML KCNA1 KCNA10 KCNMB4 KLRC1 LDLRAD1 LMAN2L LMNA LRRC25 LRTM1 LSMEM1 MC4R MS4A4A MYD88 NCAPH2 NKAIN4 NPDC1 OPRM1 PERP PLA2G10 PRRT1 PTPRN RAMP1 SDC4 SGCB SHISA3 SHISA4 SLC10A1 SLC35H1 SMIM3 SPINT1 STX1A SYNDIG1 TEX29 TIGIT TM4SF18 TMEM106C TMEM174 TMEM207 TMEM213 TMEM248 TMEM30A TMEM52B TNFSF14 TSPO2 USP7	39 interacting genes: ADAM33 AGTRAP AIG1 AMELY AQP3 ASGR1 BRCA1 C2CD2L CDS2 CLEC2A CMTM7 CNIH2 COMT CTSA EFNA5 ERMP1 GOSR2 MAL NDUFB11 PAEP PLN PRAF2 PTCH1 RTP2 SCARB2 SEC22B SFT2D2 SNORC TFRC TM6SF2 TMEM14B TMEM222 TMEM60 TMEM86B TRIM63 UBIAD1 VAMP2 VAMP5 ZFPL1
Entrez ID		4118	11112
HPRD ID		01789	12238
Ensembl ID		ENSG00000172005	ENSG00000106049
Uniprot IDs		P21145	A0A024RA75 P31937
PDB IDs			2GF2 2I9P
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Protein Binding Gamma-delta T Cell Activation Anchoring Junction Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Postsynaptic Density Membrane Cell-cell Junction Organization Bicellular Tight Junction Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell Junction Organization Bicellular Tight Junction Assembly Tight Junction Assembly Tight Junction Organization Structural Molecule Activity Cell-cell Junction Assembly Leukocyte Activation	Membrane Endoplasmic Reticulum Membrane Establishment Of Protein Localization Endoplasmic Reticulum Endomembrane System Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane SNAP Receptor Activity Establishment Of Protein Localization To Membrane Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization To Plasma Membrane ER To Golgi Transport Vesicle Membrane Intracellular Protein Localization Clathrin-coated Endocytic Vesicle Membrane
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