MAL and CPLX4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MAL	CPLX4
Description		mal, T cell differentiation protein (MAL blood group)	complexin 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Membrane Apical Plasma Membrane Schmidt-Lanterman Incisure Plasma Membrane Raft Membrane Raft Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane	Plasma Membrane Membrane SNARE Complex Terminal Bouton Synapse
	Molecular Function	Protein Binding Lipid Binding Peptidase Activator Activity Involved In Apoptotic Process Structural Constituent Of Myelin Sheath	SNARE Binding Protein Binding Syntaxin Binding
	Biological Process	Membrane Raft Polarization Protein Localization To Paranode Region Of Axon Apoptotic Process Central Nervous System Development Central Nervous System Myelination Cell Differentiation Myelination Apical Protein Localization Protein Insertion Into Plasma Membrane Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Neurotransmitter Transport Exocytosis Visual Perception Synaptic Vesicle Exocytosis Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Neurotransmitter Secretion Modulation Of Chemical Synaptic Transmission
Pathways
Drugs
Diseases
GWAS			Cardiac troponin-I levels ( 31014085) Chronotype ( 27494321) Macular thickness ( 30535121) Morning vs. evening chronotype ( 27494321)
Interacting Genes		81 interacting genes: AMHR2 AQP6 BCL2L13 BTN2A1 CALN1 CD300LG CD3G CD40 CD53 CD69 CLDN14 CLDN20 CLDN7 CLDN9 CLEC4C CLSTN3 CPLX4 CREB3L1 CXADR DAGLA EDA EMP1 EVI2A FAM209A FCRL2 FIBCD1 FNDC9 GJA8 GJB1 GPR152 GRAMD1A GSG1L HIBADH IL10RA IL20RB JAML KCNA1 KCNA10 KCNMB4 KLRC1 LDLRAD1 LMAN2L LMNA LRRC25 LRTM1 LSMEM1 MC4R MS4A4A MYD88 NCAPH2 NKAIN4 NPDC1 OPRM1 PERP PLA2G10 PRRT1 PTPRN RAMP1 SDC4 SGCB SHISA3 SHISA4 SLC10A1 SLC35H1 SMIM3 SPINT1 STX1A SYNDIG1 TEX29 TIGIT TM4SF18 TMEM106C TMEM174 TMEM207 TMEM213 TMEM248 TMEM30A TMEM52B TNFSF14 TSPO2 USP7	100 interacting genes: ADIPOQ AGTRAP AIG1 AOC3 APOD AQP1 AQP9 ASGR1 ATP6V0C BMP10 BNIP2 C14orf180 C1GALT1 C3orf52 C5 CACNG1 CCL4L2 CD81 CDIPT CDS2 CLDND2 CLEC4G CLN6 CMTM5 CNIH1 CTSA CTXN3 CYB5B CYBC1 CYP4F2 DEFB127 EMD GAD2 GIMAP1 GRM2 HACD1 HHATL HMOX1 IGFBP5 INSIG2 LHFPL5 LPAR3 MAL MALL MAN2B2 MGAM NINJ2 NRM ORMDL1 PGAP2 PLN PLP2 PLPP4 PNLIPRP1 PTPN9 RTP2 SEC22B SELENOK SFTPC SLC30A2 SLC30A8 SLC35A1 SLC35A4 SLC35B4 SLC38A7 SLC39A9 SMCO4 SMIM1 SNCA STX3 STX8 SYNJ2BP TF TMEM107 TMEM120B TMEM128 TMEM14A TMEM14B TMEM19 TMEM201 TMEM203 TMEM218 TMEM229B TMEM243 TMEM254 TMEM267 TMEM42 TMEM60 TMEM79 TMEM86A TMEM97 TRAF3IP3 TSPO2 UBIAD1 VAMP4 VAMP5 VKORC1 WFDC2 YIPF6 ZFPL1
Entrez ID		4118	339302
HPRD ID		01789	13091
Ensembl ID		ENSG00000172005	ENSG00000166569
Uniprot IDs		P21145	Q7Z7G2
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Protein Binding Gamma-delta T Cell Activation Anchoring Junction Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Postsynaptic Density Membrane Cell-cell Junction Organization Bicellular Tight Junction Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell Junction Organization Bicellular Tight Junction Assembly Tight Junction Assembly Tight Junction Organization Structural Molecule Activity Cell-cell Junction Assembly Leukocyte Activation	Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Protein Binding Chemical Homeostasis Golgi Membrane Cholesterol Binding Intracellular Chemical Homeostasis Monoatomic Cation Homeostasis Pyrimidine Nucleotide-sugar Transmembrane Transport Monoatomic Ion Homeostasis Nucleotide-sugar Transmembrane Transport Homeostatic Process Vitamin K Metabolic Process Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Golgi Apparatus Spindle Pole Centrosome Cellular Homeostasis Hydrogen Peroxide Channel Activity Negative Regulation Of Chaperone-mediated Autophagy Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Inorganic Ion Homeostasis Hydrogen Peroxide Transmembrane Transport Nuclear Inner Membrane Respiratory Burst After Phagocytosis Regulation Of Chemokine Production Negative Regulation Of Lipoprotein Metabolic Process Cellular Response To CAMP Zinc:proton Antiporter Activity Zinc Ion Transmembrane Transporter Activity Pyrimidine Nucleotide-sugar Transmembrane Transporter Activity Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Zinc Ion Transmembrane Transport Menaquinone Metabolic Process Lysosome Zinc Ion Transport Glycerol Transmembrane Transport Multicellular Organismal-level Chemical Homeostasis Intracellular Zinc Ion Homeostasis Positive Regulation Of Chemokine Production Cortical Endoplasmic Reticulum Regulation Of Chaperone-mediated Autophagy Endomembrane System Long-chain Fatty Acid Catabolic Process Regulation Of Cellular Localization
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