MAL and PRRT1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MAL	PRRT1
Description		mal, T cell differentiation protein (MAL blood group)	proline rich transmembrane protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Membrane Apical Plasma Membrane Schmidt-Lanterman Incisure Plasma Membrane Raft Membrane Raft Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane	Plasma Membrane Membrane Synaptic Vesicle Membrane Synapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding Lipid Binding Peptidase Activator Activity Involved In Apoptotic Process Structural Constituent Of Myelin Sheath	Protein Binding Signaling Receptor Regulator Activity Identical Protein Binding
	Biological Process	Membrane Raft Polarization Protein Localization To Paranode Region Of Axon Apoptotic Process Central Nervous System Development Central Nervous System Myelination Cell Differentiation Myelination Apical Protein Localization Protein Insertion Into Plasma Membrane Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Protein Phosphorylation Learning Or Memory Intracellular Protein Localization Protein Localization To Cell Surface Synapse Organization Long-term Synaptic Potentiation Long-term Synaptic Depression Regulation Of AMPA Receptor Activity
Pathways
Drugs
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Epstein-Barr virus immune response (EBNA-1) ( 23326239) Hip circumference adjusted for BMI ( 34021172) IgG glycosylation ( 23382691) Inflammatory bowel disease ( 28067908) Intraocular pressure ( 29617998) Prostate cancer ( 23535732) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Systolic blood pressure ( 30578418) Ulcerative colitis ( 28067908) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		81 interacting genes: AMHR2 AQP6 BCL2L13 BTN2A1 CALN1 CD300LG CD3G CD40 CD53 CD69 CLDN14 CLDN20 CLDN7 CLDN9 CLEC4C CLSTN3 CPLX4 CREB3L1 CXADR DAGLA EDA EMP1 EVI2A FAM209A FCRL2 FIBCD1 FNDC9 GJA8 GJB1 GPR152 GRAMD1A GSG1L HIBADH IL10RA IL20RB JAML KCNA1 KCNA10 KCNMB4 KLRC1 LDLRAD1 LMAN2L LMNA LRRC25 LRTM1 LSMEM1 MC4R MS4A4A MYD88 NCAPH2 NKAIN4 NPDC1 OPRM1 PERP PLA2G10 PRRT1 PTPRN RAMP1 SDC4 SGCB SHISA3 SHISA4 SLC10A1 SLC35H1 SMIM3 SPINT1 STX1A SYNDIG1 TEX29 TIGIT TM4SF18 TMEM106C TMEM174 TMEM207 TMEM213 TMEM248 TMEM30A TMEM52B TNFSF14 TSPO2 USP7	3 interacting genes: MAL TRIM55 TRIM63
Entrez ID		4118	80863
HPRD ID		01789	10794
Ensembl ID		ENSG00000172005	ENSG00000204314
Uniprot IDs		P21145	A0A1U9X8D6 Q99946
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Protein Binding Gamma-delta T Cell Activation Anchoring Junction Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Postsynaptic Density Membrane Cell-cell Junction Organization Bicellular Tight Junction Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell Junction Organization Bicellular Tight Junction Assembly Tight Junction Assembly Tight Junction Organization Structural Molecule Activity Cell-cell Junction Assembly Leukocyte Activation	Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Protein Localization To Paranode Region Of Axon Protein Localization To Axon Schmidt-Lanterman Incisure Membrane Raft Distribution Membrane Raft Localization Structural Constituent Of Myelin Sheath Membrane Raft Polarization Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Central Nervous System Myelination Peptidase Activator Activity Involved In Apoptotic Process Ubiquitin Protein Ligase Activity Microtubule Diapedesis Muscle Atrophy Titin Binding Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Skeletal Muscle Atrophy Skeletal Muscle Adaptation Contractile Muscle Fiber Striated Muscle Atrophy Apical Protein Localization Leukocyte Migration Involved In Inflammatory Response Negative Regulation Of Glycolytic Process Macrophage Migration Protein Ubiquitination Innate Immune Response M Band Negative Regulation Of ATP Metabolic Process Membrane Raft Organization Protein Modification By Small Protein Conjugation Defense Response To Symbiont Defense Response To Other Organism Plasma Membrane Raft Response To Electrical Stimulus Negative Regulation Of Cardiac Muscle Hypertrophy Post-translational Protein Modification Negative Regulation Of Muscle Hypertrophy Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Glycolytic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Canonical NF-kappaB Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Carbohydrate Catabolic Process Protein Insertion Into Membrane Response To Other Organism Regulation Of Cardiac Muscle Hypertrophy Protein K63-linked Ubiquitination Regulation Of ATP Metabolic Process
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