MAL and TMEM174

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MAL	TMEM174
Description		mal, T cell differentiation protein (MAL blood group)	transmembrane protein 174
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Membrane Apical Plasma Membrane Schmidt-Lanterman Incisure Plasma Membrane Raft Membrane Raft Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Apical Plasma Membrane
	Molecular Function	Protein Binding Lipid Binding Peptidase Activator Activity Involved In Apoptotic Process Structural Constituent Of Myelin Sheath	Protein Binding
	Biological Process	Membrane Raft Polarization Protein Localization To Paranode Region Of Axon Apoptotic Process Central Nervous System Development Central Nervous System Myelination Cell Differentiation Myelination Apical Protein Localization Protein Insertion Into Plasma Membrane Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Phosphate Ion Homeostasis
Pathways
Drugs
Diseases
GWAS			Blood urea nitrogen levels ( 29403010) Eyebrow thickness ( 26926045) Hemoglobin levels ( 33491795) Monobrow ( 27182965) Monobrow thickness ( 26926045) Renal function-related traits (BUN) ( 22797727)
Interacting Genes		81 interacting genes: AMHR2 AQP6 BCL2L13 BTN2A1 CALN1 CD300LG CD3G CD40 CD53 CD69 CLDN14 CLDN20 CLDN7 CLDN9 CLEC4C CLSTN3 CPLX4 CREB3L1 CXADR DAGLA EDA EMP1 EVI2A FAM209A FCRL2 FIBCD1 FNDC9 GJA8 GJB1 GPR152 GRAMD1A GSG1L HIBADH IL10RA IL20RB JAML KCNA1 KCNA10 KCNMB4 KLRC1 LDLRAD1 LMAN2L LMNA LRRC25 LRTM1 LSMEM1 MC4R MS4A4A MYD88 NCAPH2 NKAIN4 NPDC1 OPRM1 PERP PLA2G10 PRRT1 PTPRN RAMP1 SDC4 SGCB SHISA3 SHISA4 SLC10A1 SLC35H1 SMIM3 SPINT1 STX1A SYNDIG1 TEX29 TIGIT TM4SF18 TMEM106C TMEM174 TMEM207 TMEM213 TMEM248 TMEM30A TMEM52B TNFSF14 TSPO2 USP7	11 interacting genes: BAG3 CACNB2 CMTM7 CYSRT1 EMD KRT31 KRT34 MAL PLLP SEC22A SGTA
Entrez ID		4118	134288
HPRD ID		01789	14432
Ensembl ID		ENSG00000172005	ENSG00000164325
Uniprot IDs		P21145	Q8WUU8
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Protein Binding Gamma-delta T Cell Activation Anchoring Junction Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Postsynaptic Density Membrane Cell-cell Junction Organization Bicellular Tight Junction Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell Junction Organization Bicellular Tight Junction Assembly Tight Junction Assembly Tight Junction Organization Structural Molecule Activity Cell-cell Junction Assembly Leukocyte Activation	Structural Constituent Of Myelin Sheath Positive Regulation Of Protein Export From Nucleus Epidermis Development Regulation Of Protein Export From Nucleus Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels Membrane Depolarization During Atrial Cardiac Muscle Cell Action Potential Cellular Localization Positive Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Voltage-gated Calcium Channel Activity Involved In AV Node Cell Action Potential Voltage-gated Calcium Channel Activity Involved In Cardiac Muscle Cell Action Potential TMEM240-body Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Intracellular Protein Transport Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization Protein Insertion Into Plasma Membrane Myelination Axon Ensheathment Membrane Raft Polarization Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Protein Insertion Into Membrane TRC Complex Regulation Of Transcytosis B-1a B Cell Differentiation Regulation Of Nucleocytoplasmic Transport Protein Localization To Paranode Region Of Axon BAT3 Complex Binding Compact Myelin B-1 B Cell Differentiation Membrane Depolarization During AV Node Cell Action Potential Supramolecular Fiber Organization Peptidase Activator Activity Involved In Apoptotic Process Positive Regulation Of Aggrephagy Positive Regulation Of Intracellular Transport Localization Within Membrane Photoreceptor Ribbon Synapse Regulation Of Intracellular Protein Transport Developmental Process Intermediate Filament Membrane Raft Distribution Negative Regulation Of ERAD Pathway Chaperone-mediated Autophagy Negative Regulation Of Protein Targeting To Mitochondrion Aggresome Assembly Cortical Endoplasmic Reticulum Membrane Raft Localization Negative Regulation Of Establishment Of Protein Localization To Mitochondrion
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?