PERP

Description		p53 apoptosis effector related to PMP22
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Golgi Apparatus Plasma Membrane Cell-cell Junction Membrane Desmosome Anchoring Junction
	Molecular Function	Protein Binding
	Biological Process	Tissue Homeostasis Desmosome Organization Apoptotic Process Cell Adhesion Notch Signaling Pathway Heterotypic Cell-cell Adhesion Positive Regulation Of Proteolysis Mammary Gland Duct Morphogenesis Positive Regulation Of T Cell Apoptotic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Neutrophil Chemotaxis Amelogenesis Cell-cell Adhesion
Pathways		TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain Formation of the cornified envelope
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Bulimia nervosa ( 23568457) Systemic lupus erythematosus ( 26663301)
Interacting Genes		2 interacting genes: ABHD16A MAL
Entrez ID		64065
HPRD ID		17836
Ensembl ID		ENSG00000112378
Uniprot IDs		Q96FX8
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Phosphatidylserine Catabolic Process Prostaglandin Catabolic Process Membrane Raft Polarization Protein Localization To Paranode Region Of Axon Peptidase Activator Activity Involved In Apoptotic Process Monoacylglycerol Catabolic Process Protein Localization To Axon Schmidt-Lanterman Incisure Membrane Raft Distribution Membrane Raft Localization Structural Constituent Of Myelin Sheath Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Central Nervous System Myelination Monoacylglycerol Lipase Activity Apical Protein Localization Phosphatidylserine Metabolic Process Phosphatidylcholine Lysophospholipase Activity Glycerophospholipid Catabolic Process Phospholipase Activity Acylglycerol Catabolic Process Membrane Raft Organization Modified Amino Acid Catabolic Process Plasma Membrane Raft Phospholipid Catabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Protein Insertion Into Membrane Fatty Acid Derivative Metabolic Process Acylglycerol Metabolic Process Neutral Lipid Metabolic Process Myelination Axon Ensheathment Central Nervous System Development Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Modified Amino Acid Metabolic Process Organophosphate Catabolic Process
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