PERP and ABHD16A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PERP	ABHD16A
Description		p53 apoptosis effector related to PMP22	abhydrolase domain containing 16A, phospholipase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Golgi Apparatus Plasma Membrane Cell-cell Junction Membrane Desmosome Anchoring Junction	Membrane
	Molecular Function	Protein Binding	Phospholipase Activity Phosphatidylcholine Lysophospholipase Activity Protein Binding Hydrolase Activity Monoacylglycerol Lipase Activity
	Biological Process	Tissue Homeostasis Desmosome Organization Apoptotic Process Cell Adhesion Notch Signaling Pathway Heterotypic Cell-cell Adhesion Positive Regulation Of Proteolysis Mammary Gland Duct Morphogenesis Positive Regulation Of T Cell Apoptotic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Neutrophil Chemotaxis Amelogenesis Cell-cell Adhesion	Lipid Metabolic Process Phosphatidylserine Catabolic Process Monoacylglycerol Catabolic Process Prostaglandin Catabolic Process
Pathways		TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain Formation of the cornified envelope
Drugs
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Bulimia nervosa ( 23568457) Systemic lupus erythematosus ( 26663301)	Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Monocyte percentage of white cells ( 32888494) Ulcerative colitis ( 28067908)
Interacting Genes		2 interacting genes: ABHD16A MAL	69 interacting genes: AGPAT3 AQP6 AQP7 ATP5MC3 ATP5PF BRI3 CBARP CIDEB CREB3 CYP1A2 DNAJC1 DTX2 EBP ERGIC3 FDPS FKBP7 GDAP1 GJA5 GOLT1A GORAB GPR152 GPRC5C GYPC HM13 HNRNPA1 HSD17B13 IFITM1 IFITM3 ITGAM LTA MLH1 MT-ND3 MT-ND4 PERP PILRB PKMYT1 POLE PRAF2 PTGS2 RETREG3 RHBDD2 RHBDL1 RNF5 SAFB SEC22B SERF1A SERF1B SLC10A1 SLC30A2 SLC7A8 SPAG4 SPAG7 STMN4 STX1B TM4SF19 TMEM139 TMEM143 TMEM147 TMEM14B TMEM222 TMEM237 TMEM31 TMEM65 TSPAN2 UNC93A UPF1 VAMP5 VMA21 WBP1L
Entrez ID		64065	7920
HPRD ID		17836	15929
Ensembl ID		ENSG00000112378	ENSG00000204427
Uniprot IDs		Q96FX8	A0A1U9X777 B3KNX9 O95870
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Phosphatidylserine Catabolic Process Prostaglandin Catabolic Process Membrane Raft Polarization Protein Localization To Paranode Region Of Axon Peptidase Activator Activity Involved In Apoptotic Process Monoacylglycerol Catabolic Process Protein Localization To Axon Schmidt-Lanterman Incisure Membrane Raft Distribution Membrane Raft Localization Structural Constituent Of Myelin Sheath Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Central Nervous System Myelination Monoacylglycerol Lipase Activity Apical Protein Localization Phosphatidylserine Metabolic Process Phosphatidylcholine Lysophospholipase Activity Glycerophospholipid Catabolic Process Phospholipase Activity Acylglycerol Catabolic Process Membrane Raft Organization Modified Amino Acid Catabolic Process Plasma Membrane Raft Phospholipid Catabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Protein Insertion Into Membrane Fatty Acid Derivative Metabolic Process Acylglycerol Metabolic Process Neutral Lipid Metabolic Process Myelination Axon Ensheathment Central Nervous System Development Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Modified Amino Acid Metabolic Process Organophosphate Catabolic Process	Membrane Endoplasmic Reticulum Membrane Protein Binding Endoplasmic Reticulum
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