MAL and CD3G

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MAL	CD3G
Description		mal, T cell differentiation protein (MAL blood group)	CD3 gamma subunit of T-cell receptor complex
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Plasma Membrane Membrane Apical Plasma Membrane Schmidt-Lanterman Incisure Plasma Membrane Raft Membrane Raft Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane	Cytosol Plasma Membrane External Side Of Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Membrane Alpha-beta T Cell Receptor Complex Gamma-delta T Cell Receptor Complex
	Molecular Function	Protein Binding Lipid Binding Peptidase Activator Activity Involved In Apoptotic Process Structural Constituent Of Myelin Sheath	Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Complex Adaptor Activity T Cell Receptor Binding Identical Protein Binding
	Biological Process	Membrane Raft Polarization Protein Localization To Paranode Region Of Axon Apoptotic Process Central Nervous System Development Central Nervous System Myelination Cell Differentiation Myelination Apical Protein Localization Protein Insertion Into Plasma Membrane Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Adaptive Immune Response Immune System Process Establishment Or Maintenance Of Cell Polarity Cell Surface Receptor Signaling Pathway Protein Transport T Cell Activation Positive Thymic T Cell Selection Gamma-delta T Cell Activation Alpha-beta T Cell Activation T Cell Receptor Signaling Pathway Protein-containing Complex Assembly Regulation Of Lymphocyte Apoptotic Process
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Co-inhibition by PD-1 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis
Drugs			Muromonab Teclistamab Odronextamab
Diseases
GWAS
Interacting Genes		81 interacting genes: AMHR2 AQP6 BCL2L13 BTN2A1 CALN1 CD300LG CD3G CD40 CD53 CD69 CLDN14 CLDN20 CLDN7 CLDN9 CLEC4C CLSTN3 CPLX4 CREB3L1 CXADR DAGLA EDA EMP1 EVI2A FAM209A FCRL2 FIBCD1 FNDC9 GJA8 GJB1 GPR152 GRAMD1A GSG1L HIBADH IL10RA IL20RB JAML KCNA1 KCNA10 KCNMB4 KLRC1 LDLRAD1 LMAN2L LMNA LRRC25 LRTM1 LSMEM1 MC4R MS4A4A MYD88 NCAPH2 NKAIN4 NPDC1 OPRM1 PERP PLA2G10 PRRT1 PTPRN RAMP1 SDC4 SGCB SHISA3 SHISA4 SLC10A1 SLC35H1 SMIM3 SPINT1 STX1A SYNDIG1 TEX29 TIGIT TM4SF18 TMEM106C TMEM174 TMEM207 TMEM213 TMEM248 TMEM30A TMEM52B TNFSF14 TSPO2 USP7	14 interacting genes: CATSPERH CD3D CD3E EMP1 KTN1 LAT MAL PMP22 TMEM19 TMEM203 TMEM54 TRA TRB TRD
Entrez ID		4118	917
HPRD ID		01789	07037
Ensembl ID		ENSG00000172005	ENSG00000160654
Uniprot IDs		P21145	B0YIY5 P09693
PDB IDs			1SY6 6JXR 7FJD 7FJE 7FJF 7PHR 7Q5U 8ES7 8ES8 8ES9 8JC0 8JCB 8TW4 8TW6 8WXE 8WY0 8WYI 8YC0 9BBC 9C3E 9CI8 9CIA 9CQ4
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Protein Binding Gamma-delta T Cell Activation Anchoring Junction Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Postsynaptic Density Membrane Cell-cell Junction Organization Bicellular Tight Junction Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell Junction Organization Bicellular Tight Junction Assembly Tight Junction Assembly Tight Junction Organization Structural Molecule Activity Cell-cell Junction Assembly Leukocyte Activation	Alpha-beta T Cell Receptor Complex T Cell Receptor Complex Detection Of Tumor Cell T Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Adaptive Immune Response Membrane Raft Distribution Immune Response To Tumor Cell Membrane Raft Localization Membrane Bleb Assembly Positive Thymic T Cell Selection Positive T Cell Selection T Cell Receptor Signaling Pathway T Cell Mediated Cytotoxicity Thymic T Cell Selection Plasma Membrane Antigen Receptor-mediated Signaling Pathway T Cell Selection Membrane Raft Organization Detection Of Biotic Stimulus Signaling Receptor Complex Adaptor Activity T Cell Mediated Immunity Immunological Synapse Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Complex Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production TCR Signalosome Leukocyte Mediated Cytotoxicity T Cell Activation Gamma-delta T Cell Receptor Complex Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development Negative Regulation Of Dopamine Receptor Signaling Pathway Membrane Raft Polarization Immune Response Immune Response-activating Signaling Pathway Alpha-beta T Cell Activation T Cell Anergy Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Renal Sodium Excretion Negative Regulation Of Dopamine Secretion Protein Localization To Paranode Region Of Axon Myelination Axon Ensheathment Compact Myelin
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