SEMG1 and KLK2

Number of citations of the paper that reports this interaction (PMID 10411640)
7

Data Source:
HPRD (in vitro)

		SEMG1	KLK2
Gene Name		semenogelin I	kallikrein-related peptidase 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Secretory Granule Extracellular Vesicular Exosome	Extracellular Region Extracellular Vesicular Exosome
	Molecular Function	Structural Molecule Activity Protein Binding	Serine-type Endopeptidase Activity
	Biological Process	Insemination	Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization
Pathways		Amyloids	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activation of Matrix Metalloproteinases Degradation of the extracellular matrix
Drugs
Diseases
GWAS			PCA3 expression level ( 23555189) Prostate-specific antigen levels ( 23359319)
Protein-Protein Interactions		6 interactors: KLK2 KLK3 PRKCA SEMG2 TGM1 UBQLN4	14 interactors: A2M APP AR IGFBP2 POLR2A SEMG1 SEMG2 SERPINA3 SERPINA4 SERPINA5 SERPINB6 SERPINC1 SERPINE1 SERPINF2
Entrez ID		6406	3817
HPRD ID		01641	01006
Ensembl ID		ENSG00000124233	ENSG00000167751
Uniprot IDs		P04279	B4DU77 P20151
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Positive Regulation Of Inflammatory Response Positive Regulation Of Dense Core Granule Biogenesis Regulation Of Blood Coagulation Regulation Of Wound Healing Factor XII Activation Cell Envelope Organization Histone H3-T6 Phosphorylation Positive Regulation Of Fibrinolysis Regulation Of Angiogenesis Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Inflammatory Response Plasminogen Activation Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Plasma Kallikrein-kinin Cascade Negative Regulation Of Glucose Import Positive Regulation Of Macrophage Differentiation Desmosome Organization Regulation Of Fibrinolysis Blood Coagulation, Intrinsic Pathway Regulation Of Platelet Aggregation Negative Regulation Of Glucose Transport Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Blood Coagulation Hemostasis Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Protein Processing Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Regulation Of Rhodopsin Mediated Signaling Pathway Positive Regulation Of Acute Inflammatory Response Negative Regulation Of CAMP Biosynthetic Process Activation Of Adenylate Cyclase Activity Fibrinolysis Regulation Of Cardiac Muscle Hypertrophy Rhodopsin Mediated Signaling Pathway Regulation Of Platelet Activation Positive Regulation Of Positive Chemotaxis Negative Regulation Of CAMP Metabolic Process Regulation Of The Force Of Heart Contraction Inactivation Of MAPK Activity Regulation Of Body Fluid Levels Wound Healing Mitotic Nuclear Envelope Disassembly	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Regulation Of Proteolysis Negative Regulation Of Catalytic Activity Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Platelet Degranulation Blood Coagulation Hemostasis Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Body Fluid Levels Regulation Of Protein Metabolic Process Wound Healing Regulation Of Catalytic Activity Response To Wounding Platelet Activation Negative Regulation Of Plasminogen Activation Negative Regulation Of Fibrinolysis Regulation Of Fibrinolysis Regulation Of Blood Coagulation Exocytosis Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Wound Healing Reproductive Process Transcription Initiation From RNA Polymerase II Promoter Fibrinolysis Positive Regulation Of Blood Coagulation Secretion By Cell Acute-phase Response Positive Regulation Of Coagulation Response To Stress DNA-templated Transcription, Initiation Positive Regulation Of Wound Healing Regulation Of Metabolic Process Secretion Mating Negative Regulation Of Blood Coagulation Cell Activation Regulation Of Inflammatory Response Negative Regulation Of Coagulation Negative Regulation Of Integrin Biosynthetic Process Regulation Of Blood Coagulation, Intrinsic Pathway
Tagcloud ?		acids amino assisted changed computer cysteine ejaculation epididymal eppin fragment fragments glycine hydrolyzed lactotransferrin live motility originally progressive protease psa recombinant reversing semenogelin seminal sperm spermatozoa spinlw1 washed	422a akt3 circuit differentially dysregulated effectors encode gleason grades kallikrein kallikreins klk14 klk15 klk3 klk4 micrornas microsatellite minisatellite mirna mirnas nucleotides pik3cg prostate proteases pseudogene repeats share silico talk
Tagcloud (Difference) ?		acids amino assisted changed computer cysteine ejaculation epididymal eppin fragment fragments glycine hydrolyzed lactotransferrin live motility originally progressive protease psa recombinant reversing semenogelin seminal sperm spermatozoa spinlw1 washed	422a akt3 circuit differentially dysregulated effectors encode gleason grades kallikrein kallikreins klk14 klk15 klk3 klk4 micrornas microsatellite minisatellite mirna mirnas nucleotides pik3cg prostate proteases pseudogene repeats share silico talk
Tagcloud (Intersection) ?