SEMG1 and KLK3

Number of citations of the paper that reports this interaction (PubMedID 24981860)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		SEMG1	KLK3
Description		semenogelin 1	kallikrein related peptidase 3
Image
GO Annotations	Cellular Component	Acrosomal Vesicle Extracellular Region Extracellular Space Nucleus Protein-containing Complex Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Secretory Granule Protein-containing Complex Extracellular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides
	Biological Process	Insemination Antibacterial Humoral Response Killing Of Cells Of Another Organism Sperm Capacitation Coagulation Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Negative Regulation Of Calcium Ion Import Positive Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Flagellated Sperm Motility	Positive Regulation Of Antibacterial Peptide Production Regulation Of Systemic Arterial Blood Pressure Proteolysis Negative Regulation Of Angiogenesis Zymogen Activation
Pathways		Antimicrobial peptides Amyloid fiber formation	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Mifepristone Metribolone Cyproterone acetate Gallium Ga-68 gozetotide Lutetium Lu-177 vipivotide tetraxetan
Diseases
GWAS		Bipolar disorder ( 31043756) Malaria ( 31844061)	Celiac disease ( 23936387) Elevated serum prostate-specific antigen levels in healthy men ( 28471803) PCA3 expression level ( 23555189) Prostate cancer ( 18264097 24753544 26034056 31562322 34012061) Prostate cancer (early onset) ( 24740154) Prostate cancer aggressiveness ( 25939597) Prostate-specific antigen levels ( 23269536 24919509 25434496 28139693) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Serum prostate-specific antigen levels ( 21160077)
Interacting Genes		9 interacting genes: EAF1 KLK2 KLK3 PRKCA PTPRF SEMG2 TGM1 UBQLN2 UBQLN4	14 interacting genes: A2M ALB EPOR FN1 IGFBP3 PLG PTHLH PZP SEMG1 SEMG2 SERPINA1 SERPINA3 SERPINA5 SLPI
Entrez ID		6406	354
HPRD ID		01641	01461
Ensembl ID		ENSG00000124233	ENSG00000142515
Uniprot IDs		P04279	P07288 Q546G3
PDB IDs		7ZRF 7ZRO 8BOO 8BVZ	2ZCH 2ZCK 2ZCL 3QUM 9F1I
Enriched GO Terms of Interacting Partners?		Zymogen Activation Extracellular Exosome Proteolysis Protein Metabolic Process Polyubiquitin Modification-dependent Protein Binding Regulation Of Systemic Arterial Blood Pressure Macromolecule Metabolic Process Secretory Granule Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Angiotensin-activated Signaling Pathway Histone H3T6 Kinase Activity Alphav-beta3 Integrin-PKCalpha Complex Chondroitin Sulfate Proteoglycan Binding Negative Regulation Of Flagellated Sperm Motility Positive Regulation Of Serine-type Endopeptidase Activity Regulation Of Proteolysis Cell Envelope Organization Autophagosome Negative Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Autophagosome Maturation Nuclear Proteasome Complex Positive Regulation Of Antibacterial Peptide Production Serine-type Peptidase Activity Protein Kinase C Signaling Negative Regulation Of Receptor Binding Negative Regulation Of Clathrin-dependent Endocytosis Serine-type Endopeptidase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Cellular Response To Stress Cytosolic Proteasome Complex Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Antibacterial Peptide Production Positive Regulation Of Antimicrobial Peptide Production Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Super Elongation Complex Regulation Of Blood Pressure Positive Regulation Of Antimicrobial Humoral Response Desmosome Assembly Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Protein-glutamine Gamma-glutamyltransferase Activity Protein Processing Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Endopeptidase Activity Regulation Of Macroautophagy Transcription Elongation Factor Activity Positive Regulation Of Epithelial Cell Proliferation Regulation Of Proteasomal Protein Catabolic Process	Extracellular Region Extracellular Space Protease Binding Platelet Alpha Granule Lumen Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity Extracellular Matrix Blood Microparticle Extracellular Exosome Coagulation Negative Regulation Of Flagellated Sperm Motility Positive Regulation Of Serine-type Endopeptidase Activity Acute-phase Response Endopeptidase Inhibitor Activity Acute Inflammatory Response Antibacterial Humoral Response Positive Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Reproductive Process Endoplasmic Reticulum Lumen Regulation Of Flagellated Sperm Motility Regulation Of Endopeptidase Activity Sperm Capacitation Antimicrobial Humoral Response Regulation Of Cilium Movement Defense Response Biological Process Involved In Interaction With Symbiont Developmental Process Involved In Reproduction Growth Factor Binding Erythropoietin Receptor Activity Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-coagulation Factor XI Complex Protein C Inhibitor-PLAT Complex Regulation Of Microtubule-based Movement Regulation Of Cell Motility Humoral Immune Response Regulation Of Locomotion Negative Regulation Of Reproductive Process Negative Regulation Of Complement Activation, Lectin Pathway Enterobactin Binding Exogenous Protein Binding Cellular Response To Calcium Ion Starvation Seminal Clot Liquefaction
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