SEMG1

Description		semenogelin 1
Image
GO Annotations	Cellular Component	Acrosomal Vesicle Extracellular Region Extracellular Space Nucleus Protein-containing Complex Extracellular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding
	Biological Process	Insemination Antibacterial Humoral Response Killing Of Cells Of Another Organism Sperm Capacitation Coagulation Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Negative Regulation Of Calcium Ion Import Positive Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Flagellated Sperm Motility
Pathways		Antimicrobial peptides Amyloid fiber formation
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Bipolar disorder ( 31043756) Malaria ( 31844061)
Interacting Genes		9 interacting genes: EAF1 KLK2 KLK3 PRKCA PTPRF SEMG2 TGM1 UBQLN2 UBQLN4
Entrez ID		6406
HPRD ID		01641
Ensembl ID		ENSG00000124233
Uniprot IDs		P04279
PDB IDs		7ZRF 7ZRO 8BOO 8BVZ
Enriched GO Terms of Interacting Partners?		Zymogen Activation Extracellular Exosome Proteolysis Protein Metabolic Process Polyubiquitin Modification-dependent Protein Binding Regulation Of Systemic Arterial Blood Pressure Macromolecule Metabolic Process Secretory Granule Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Angiotensin-activated Signaling Pathway Histone H3T6 Kinase Activity Alphav-beta3 Integrin-PKCalpha Complex Chondroitin Sulfate Proteoglycan Binding Negative Regulation Of Flagellated Sperm Motility Positive Regulation Of Serine-type Endopeptidase Activity Regulation Of Proteolysis Cell Envelope Organization Autophagosome Negative Regulation Of G Protein-coupled Receptor Internalization Negative Regulation Of Autophagosome Maturation Nuclear Proteasome Complex Positive Regulation Of Antibacterial Peptide Production Serine-type Peptidase Activity Protein Kinase C Signaling Negative Regulation Of Receptor Binding Negative Regulation Of Clathrin-dependent Endocytosis Serine-type Endopeptidase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Cellular Response To Stress Cytosolic Proteasome Complex Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Antibacterial Peptide Production Positive Regulation Of Antimicrobial Peptide Production Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Super Elongation Complex Regulation Of Blood Pressure Positive Regulation Of Antimicrobial Humoral Response Desmosome Assembly Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Protein-glutamine Gamma-glutamyltransferase Activity Protein Processing Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Endopeptidase Activity Regulation Of Macroautophagy Transcription Elongation Factor Activity Positive Regulation Of Epithelial Cell Proliferation Regulation Of Proteasomal Protein Catabolic Process
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