CSNK1G2 and RAP1GAP

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		CSNK1G2	RAP1GAP
Description		casein kinase 1 gamma 2	RAP1 GTPase activating protein
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Cell Cortex Membrane	Golgi Membrane Cytoplasm Early Endosome Golgi Apparatus Cytosol Membrane Axon Dendrite Neuronal Cell Body
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	GTPase Activity GTPase Activator Activity Protein Binding GTPase Regulator Activity Small GTPase Binding Protein Homodimerization Activity
	Biological Process	Protein Phosphorylation Endocytosis Signal Transduction Wnt Signaling Pathway Sphingolipid Biosynthetic Process Positive Regulation Of Canonical Wnt Signaling Pathway	Adaptive Immune Response Phagocytosis Signal Transduction Positive Regulation Of Cell-cell Adhesion Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Negative Regulation Of Neuron Differentiation Positive Regulation Of Phagocytosis Regulation Of Small GTPase Mediated Signal Transduction Establishment Of Localization In Cell Cell-cell Adhesion Negative Regulation Of Microvillus Assembly Negative Regulation Of Thyroid Gland Epithelial Cell Proliferation Cellular Response To Glial Cell Derived Neurotrophic Factor
Pathways		Sphingolipid de novo biosynthesis Disassembly of the destruction complex and recruitment of AXIN to the membrane	Rap1 signalling RET signaling
Drugs		IC261 N-(2-Aminoethyl)-5-Chloroisoquinoline-8-Sulfonamide 5-iodotubercidin
Diseases
GWAS		Body mass index ( 25673413) Coronary artery disease ( 29212778) Periodontitis (stage III/IV grade C) ( 33745150) Red cell distribution width ( 27863252 32888494) Severe insulin-deficient type 2 diabetes ( 34737425)	Abdominal aortic calcification levels ( 31659325) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Liver enzyme levels ( 18940312) Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483) Neurocognitive impairment in HIV-1 infection (continuous) ( 28447399) Serum alkaline phosphatase levels ( 31666285)
Interacting Genes		17 interacting genes: APP APPBP2 CERT1 CLSPN DBNDD2 IRS4 KRTAP10-7 MTA1 NCK1 OGT PER1 PPP1R14A RAP1GAP RUNDC3B SMAD3 SNCA WDCP	18 interacting genes: AFDN BRAF CDK1 CSNK1G2 DSCR9 DYNC1I1 GNAZ LCOR MAP1LC3B MAPK6 MEX3B PFN2 PLK1 PRKACA RALGDS RAP1A VPS26C ZBTB12
Entrez ID		1455	5909
HPRD ID		03738	02609
Ensembl ID		ENSG00000133275	ENSG00000076864
Uniprot IDs		P78368	P47736 X6R8W7
PDB IDs		2C47	1SRQ 3BRW
Enriched GO Terms of Interacting Partners?		Regulation Of Cell Junction Assembly Regulation Of Phosphorus Metabolic Process Negative Regulation Of MiRNA Transcription Regulation Of Presynapse Organization Insulin Receptor Binding Chemical Homeostasis Negative Regulation Of RNA Biosynthetic Process Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Transcription By RNA Polymerase II Response To Growth Factor Ephrin Receptor Binding Regulation Of Protein Metabolic Process Cellular Response To Growth Factor Stimulus Negative Regulation Of RNA Metabolic Process Regulation Of Presynapse Assembly Negative Regulation Of DNA-templated Transcription Amyloid Fibril Formation Regulation Of Neurotransmitter Uptake Regulation Of Generation Of Precursor Metabolites And Energy Cellular Response To Copper Ion Chromatin DNA Binding Negative Regulation Of Protein Catabolic Process Circadian Regulation Of Gene Expression Photoperiodism Entrainment Of Circadian Clock By Photoperiod Entrainment Of Circadian Clock Circadian Rhythm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Microglial Cell Activation Regulation Of Protein Catabolic Process Regulation Of Supramolecular Fiber Organization Leukocyte Activation Involved In Inflammatory Response Regulation Of Synapse Assembly Response To Copper Ion Positive Regulation Of Endocytosis Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Protein Metabolic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Response To Endoplasmic Reticulum Stress Locomotory Behavior Positive Regulation Of Nitric Oxide Metabolic Process Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Protein Kinase Inhibitor Activity	Protein Phosphorylation Phosphorylation Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase Activity Negative Regulation Of Synaptic Vesicle Exocytosis Regulation Of Synaptic Vesicle Exocytosis Kinase Activity Phosphate-containing Compound Metabolic Process Mitotic Nuclear Membrane Disassembly Regulation Of Neurotransmitter Secretion Nuclear Membrane Disassembly Membrane Disassembly Intracellular Signaling Cassette Nucleotide Binding Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Regulated Secretory Pathway Regulation Of Secretion By Cell Regulation Of Protein Localization Protein Localization To Site Of Double-strand Break Regulation Of Secretion Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Secretion By Cell Postsynaptic Modulation Of Chemical Synaptic Transmission Synaptic Vesicle Exocytosis Positive Regulation Of Protein Modification Process Mitotic G2 DNA Damage Checkpoint Signaling Negative Regulation Of Exocytosis Establishment Of Endothelial Barrier Chromosome Condensation Negative Regulation Of Secretion Positive Regulation Of D-glucose Transmembrane Transport Pronuclear Fusion Spindle Microtubule Endothelial Cell Development Peptidyl-serine Phosphorylation Regulation Of Exocytosis Protein Modification Process Nuclear Membrane Organization Centrosome Cycle Sperm Midpiece Presynapse Intracellular Signal Transduction Postsynapse Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Protein Phosphorylation Modulation Of Chemical Synaptic Transmission MAPK Cascade ERK1 And ERK2 Cascade Positive Regulation Of Stress Fiber Assembly
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