RNF123 and GRIK1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		RNF123	GRIK1
Description		ring finger protein 123	glutamate ionotropic receptor kainate type subunit 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Nuclear Membrane	Plasma Membrane Membrane Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Synapse Postsynaptic Membrane Postsynaptic Density Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Glutamate-gated Receptor Activity Monoatomic Ion Channel Activity Ligand-gated Monoatomic Ion Channel Activity Kainate Selective Glutamate Receptor Activity Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Canonical NF-kappaB Signal Transduction Protein Ubiquitination Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Maturation	Monoatomic Ion Transport Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Nervous System Development Central Nervous System Development Calcium-mediated Signaling Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential
Pathways		Ub-specific processing proteases Antigen processing: Ubiquitination & Proteasome degradation	Activation of Na-permeable kainate receptors Activation of Ca-permeable Kainate Receptor
Drugs			Glutamic acid Butabarbital Topiramate Tezampanel
Diseases
GWAS		Age at first birth ( 27798627) Appendicular lean mass ( 33097823) Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Depressive symptoms (binary sum-score) ( 31530331) Extremely high intelligence ( 29520040) Hemoglobin levels ( 32327693) Household income ( 31844048) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Multisite chronic pain ( 31194737) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Body mass index ( 22446040) Breast cancer ( 17903305) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Forehead morphology ( 29921221) Generalized epilepsy ( 30531953) Glucocorticoid-induced osteonecrosis ( 26265699) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Hepatocellular carcinoma ( 22807686) Hyperactive-impulsive symptoms ( 18821565) Lung cancer ( 34062886) Periodontitis (DPAL) ( 24024966) Plasma parathyroid hormone levels ( 30134803) Refractive error ( 32231278) Response to statin therapy ( 20339536) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		18 interacting genes: APP CDKN1B EMD GRIK1 LCOR LMNA LMNB1 MORC3 MTDH RB1 SMAD2 SMAD9 TMPO UBAC1 UBC UBE2D1 UBE2D2 UBE2W	31 interacting genes: COPS5 CYSLTR2 DLG4 DLST DNAJB9 FLNA GORASP2 GRIK2 GRIK3 GRIK4 GRIK5 GRIP1 HOMER1 HSP90B1 KALRN KCNQ2 LDB2 PICK1 PTPRD RANBP9 RNF123 SDCBP SEPTIN7 SIPA1L3 SNAPIN SRI ST13 TAAR1 UBE2O ZFC3H1 ZNF592
Entrez ID		63891	2897
HPRD ID		11499	00693
Ensembl ID		ENSG00000164068	ENSG00000171189
Uniprot IDs		Q5XPI4	B7Z256 B7Z3V7 E7ENK3 E7EPY9 E7EPZ0 E9PD61 P39086
PDB IDs		2MA6	2ZNS 2ZNT 2ZNU 3FUZ 3FV1 3FV2 3FVG 3FVK 3FVN 3FVO 4MF3
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Nuclear Lamina Nucleus Nucleoplasm Ubiquitin Protein Ligase Binding Nuclear Membrane Lamin Filament Nuclear Pore Localization Ubiquitin Conjugating Enzyme Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Nuclear Inner Membrane SMAD Protein Complex Negative Regulation Of Biosynthetic Process Heteromeric SMAD Protein Complex Negative Regulation Of RNA Metabolic Process Nuclear Envelope Negative Regulation Of Cell Population Proliferation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nuclear Lamina Protein Localization To Nuclear Envelope I-SMAD Binding Negative Regulation Of Metabolic Process Epigenetic Regulation Of Gene Expression Intracellular Signal Transduction Nuclear Envelope Organization Negative Regulation Of Transcription By RNA Polymerase II Response To Growth Factor Nuclear Matrix SMAD Protein Signal Transduction Disordered Domain Specific Binding Protein Ubiquitination Negative Regulation Of Epithelial Cell Apoptotic Process Nuclear Migration Heterochromatin Formation Amyloid Fibril Formation Ionotropic Glutamate Receptor Signaling Pathway Neuron Maturation Cell Surface Receptor Signaling Pathway Nucleus Localization Negative Regulation Of Fibroblast Proliferation Protein Modification By Small Protein Conjugation Aortic Valve Morphogenesis Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression Ligand-gated Ion Channel Signaling Pathway Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion	Kainate Selective Glutamate Receptor Complex Kainate Selective Glutamate Receptor Activity Glutamate Receptor Signaling Pathway Trans-synaptic Signaling Synaptic Signaling Ionotropic Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Ligand-gated Ion Channel Signaling Pathway Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Regulation Of Cell Communication Regulation Of Signaling Synapse Cell-cell Signaling Signaling Cell Communication Modulation Of Chemical Synaptic Transmission Presynaptic Membrane Regulation Of Presynaptic Membrane Potential Ligand-gated Monoatomic Ion Channel Activity Glutamate-gated Receptor Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Synaptic Transmission, Glutamatergic Postsynaptic Density Membrane Hippocampal Mossy Fiber To CA3 Synapse Receptor Clustering Postsynaptic Membrane Localization Within Membrane Postsynaptic Density Monoatomic Ion Channel Activity Regulation Of Membrane Potential Dendrite Cytoplasm Protein Localization To Membrane Regulation Of Postsynaptic Membrane Potential Negative Regulation Of Synaptic Transmission Glutamatergic Synapse Protein Sequestering Activity Plasma Membrane Synaptic Vesicle Maturation Neuron Spine Positive Regulation Of Neuron Projection Arborization Synaptic Vesicle Negative Regulation Of Synaptic Transmission, Glutamatergic Glutamate-gated Calcium Ion Channel Activity Regulation Of Signal Transduction Perikaryon Glutamate Receptor Activity Protein-containing Complex Localization Cellular Localization Regulation Of Neuron Projection Arborization Regulation Of Synaptic Transmission, Glutamatergic
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