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RNF123 and CDKN1B
Number of citations of the paper that reports this interaction (PMID
15531880
)
100
Data Source:
BioGRID
(affinity chromatography technology, pull down)
RNF123
CDKN1B
Gene Name
ring finger protein 123
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
Image
Gene Ontology Annotations
Cellular Component
Cytoplasm
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Cul4A-RING E3 Ubiquitin Ligase Complex
Molecular Function
Zinc Ion Binding
Ligase Activity
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Transforming Growth Factor Beta Receptor, Cytoplasmic Mediator Activity
Protein Binding
Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
Protein Phosphatase Binding
Hsp70 Protein Binding
Protein Complex Binding
Chaperone Binding
Biological Process
Protein Ubiquitination
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Response To Hypoxia
Potassium Ion Transport
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Cell Cycle Arrest
Epidermal Growth Factor Receptor Signaling Pathway
Sensory Perception Of Sound
Positive Regulation Of Cell Proliferation
Negative Regulation Of Cell Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Response To Glucose
Positive Regulation Of Cell Death
Negative Regulation Of Cell Growth
Positive Regulation Of Microtubule Polymerization
Response To Estradiol
Negative Regulation Of Kinase Activity
Fc-epsilon Receptor Signaling Pathway
Negative Regulation Of Phosphorylation
Response To Drug
Negative Regulation Of Apoptotic Process
Response To Amino Acid
Response To Peptide Hormone
Innate Immune Response
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Mitotic Cell Cycle
Response To Cadmium Ion
Neurotrophin TRK Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Autophagic Cell Death
Inner Ear Development
Negative Regulation Of Cellular Component Movement
Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Cellular Response To Antibiotic
Cellular Response To Lithium Ion
Cellular Response To Organic Cyclic Compound
Mitotic Cell Cycle Arrest
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Adaptive Immune System
Signaling by the B Cell Receptor (BCR)
Signaling by FGFR in disease
Cellular Senescence
p53-Dependent G1/S DNA damage checkpoint
Cyclin E associated events during G1/S transition
AKT phosphorylates targets in the cytosol
Signaling by EGFRvIII in Cancer
Signaling by SCF-KIT
Downstream signaling events of B Cell Receptor (BCR)
DAP12 signaling
PI3K/AKT activation
PI-3K cascade
G1/S Transition
Removal of licensing factors from origins
Switching of origins to a post-replicative state
Mitotic G1-G1/S phases
Signaling by PDGF
DAP12 interactions
DNA Damage/Telomere Stress Induced Senescence
GAB1 signalosome
Senescence-Associated Secretory Phenotype (SASP)
S Phase
Signaling by ERBB4
Constitutive PI3K/AKT Signaling in Cancer
Role of LAT2/NTAL/LAB on calcium mobilization
PI3K events in ERBB4 signaling
Signaling by ERBB2
Signaling by EGFR
SCF(Skp2)-mediated degradation of p27/p21
Downstream signal transduction
Signaling by EGFR in Cancer
Fc epsilon receptor (FCERI) signaling
Cyclin A:Cdk2-associated events at S phase entry
SCF(Skp2)-mediated degradation of p27/p21
PI3K/AKT Signaling in Cancer
Adaptive Immune System
PIP3 activates AKT signaling
Orc1 removal from chromatin
p53-Dependent G1 DNA Damage Response
PI3K events in ERBB2 signaling
Downstream signaling of activated FGFR
G1/S DNA Damage Checkpoints
Innate Immune System
Signalling by NGF
Synthesis of DNA
G1 Phase
Regulation of DNA replication
Signaling by Ligand-Responsive EGFR Variants in Cancer
NGF signalling via TRKA from the plasma membrane
Signaling by Overexpressed Wild-Type EGFR in Cancer
Cell Cycle, Mitotic
Signaling by FGFR
Orc1 removal from chromatin
Cyclin D associated events in G1
Cell Cycle Checkpoints
Drugs
Diseases
GWAS
Systemic lupus erythematosus (
23273568
)
Protein-Protein Interactions
5 interactors:
CDKN1B
SMAD2
SMAD9
UBAC1
UBE2W
62 interactors:
ABL1
AKT1
ARHGDIA
CAMK1
CASP8
CCNA1
CCNA2
CCNB1
CCND1
CCND2
CCND3
CCNE2
CDC34
CDK2
CDK3
CDK4
CDK5
CKS1B
COPS5
CUL1
CUL4A
GRB2
HIST1H1A
HIST1H1B
IRF1
KAT2B
KPNA1
KPNA3
KPNA4
KPNA5
KPNA6
LYN
MAPK10
MCM7
NUP50
PIN1
PSMB1
RCHY1
RNF123
RPS6KA1
SGK1
SKP1
SKP2
SPDYA
SRC
STMN1
TRAF2
TSC2
UBAC1
UBB
UBE2B
UBE2D2
UBE3A
UCHL1
XPO1
YES1
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
Entrez ID
63891
1027
HPRD ID
11499
02867
Ensembl ID
ENSG00000164068
ENSG00000111276
Uniprot IDs
C9JS59
Q5XPI4
P46527
Q6I9V6
PDB IDs
2MA6
1H27
1JSU
2AST
Enriched GO Terms of Interacting Partners
?
Cellular Response To Organic Cyclic Compound
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Cellular Response To Organic Substance
Ureteric Bud Development
Mesonephric Tubule Development
Mesonephric Epithelium Development
Mesonephros Development
Response To Glucose
Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry
Kidney Epithelium Development
Response To Organic Cyclic Compound
Enzyme Linked Receptor Protein Signaling Pathway
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Carbohydrate
Response To Organic Substance
Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry
Zygotic Specification Of Dorsal/ventral Axis
Response To Transforming Growth Factor Beta
Protein Metabolic Process
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Positive Regulation Of Mesoderm Development
Primary MiRNA Processing
Autophagic Cell Death
Regulation Of Nodal Signaling Pathway
Common-partner SMAD Protein Phosphorylation
Response To Hypoxia
Positive Regulation Of Activin Receptor Signaling Pathway
Mullerian Duct Regression
Cellular Protein Modification Process
Kidney Development
Renal System Development
SMAD Protein Complex Assembly
Urogenital System Development
Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Paraxial Mesoderm Morphogenesis
Positive Regulation Of Microtubule Polymerization
Misfolded Or Incompletely Synthesized Protein Catabolic Process
Cellular Response To Misfolded Protein
Nodal Signaling Pathway
Mitotic Cell Cycle Arrest
Response To Misfolded Protein
Cellular Response To Lithium Ion
Anatomical Structure Regression
Cellular Response To Antibiotic
Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Intracellular Signal Transduction
Production Of MiRNAs Involved In Gene Silencing By MiRNA
Embryonic Foregut Morphogenesis
Cell Cycle
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Regulation Of Protein Metabolic Process
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle
Regulation Of Cellular Protein Metabolic Process
Cell Cycle Process
Mitotic Cell Cycle
Mitotic Cell Cycle Process
Regulation Of Protein Kinase Activity
Regulation Of Phosphorylation
Regulation Of Phosphorus Metabolic Process
Regulation Of Kinase Activity
Regulation Of Protein Phosphorylation
Regulation Of Catalytic Activity
Positive Regulation Of Cellular Metabolic Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Response To Organic Substance
Cell Communication
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Cellular Response To Organic Substance
Positive Regulation Of Transferase Activity
Cellular Response To Stimulus
Positive Regulation Of Protein Modification Process
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Regulation Of Cellular Process
Cellular Protein Modification Process
Regulation Of Metabolic Process
Signal Transduction
Positive Regulation Of Cell Cycle
Signaling
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Response To Stimulus
Protein Catabolic Process
Apoptotic Process
Regulation Of Intracellular Transport
Programmed Cell Death
Viral Process
G2/M Transition Of Mitotic Cell Cycle
Regulation Of Protein Localization
Cell Death
Death
Positive Regulation Of Intracellular Transport
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Organelle Organization
Tagcloud
?
aggregated
anaplastic
atc
braf
cdkn2c
ctnnb1
eif1ax
exclusive
exome
harbored
hypermutator
landscape
mismatch
mlh
mlh1
mlh3
msh5
msh6
mutational
mutually
nf1
nf2
nras
ontology
pik3ca
ret
unresponsive
ush2a
v600e
Tagcloud (Difference)
?
aggregated
anaplastic
atc
braf
cdkn2c
ctnnb1
eif1ax
exclusive
exome
harbored
hypermutator
landscape
mismatch
mlh
mlh1
mlh3
msh5
msh6
mutational
mutually
nf1
nf2
nras
ontology
pik3ca
ret
unresponsive
ush2a
v600e
Tagcloud (Intersection)
?