RNF123 and UBAC1

Number of citations of the paper that reports this interaction (PubMedID 15531880)
0

Data Source:
HPRD (in vivo, in vitro)

		RNF123	UBAC1
Description		ring finger protein 123	UBA domain containing 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Nuclear Membrane	Ubiquitin Ligase Complex Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Polyubiquitin Modification-dependent Protein Binding Proteasome Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Canonical NF-kappaB Signal Transduction Protein Ubiquitination Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Maturation	Protein Ubiquitination Protein Maturation
Pathways		Ub-specific processing proteases Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Age at first birth ( 27798627) Appendicular lean mass ( 33097823) Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Depressive symptoms (binary sum-score) ( 31530331) Extremely high intelligence ( 29520040) Hemoglobin levels ( 32327693) Household income ( 31844048) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Multisite chronic pain ( 31194737) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Lung adenocarcinoma (survival time) in never smokers ( 32699080) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Ulcerative colitis ( 28067908)
Interacting Genes		18 interacting genes: APP CDKN1B EMD GRIK1 LCOR LMNA LMNB1 MORC3 MTDH RB1 SMAD2 SMAD9 TMPO UBAC1 UBC UBE2D1 UBE2D2 UBE2W	37 interacting genes: AIRE APP ARRDC3 CARD14 CCDC138 CDKN1B CPSF6 CSNK2A1 DAZAP2 DVL2 FAM168A FAS HOXA2 HTT IGFBP6 LAPTM5 MAP3K1 MCM10 MECOM MGAT3 NEDD4L PLAAT2 PLEKHB2 POU6F2 PPP1CB RNF11 RNF123 RNF216 SMURF1 SPART TRIM2 TRIM39 UBC UBQLN2 WWP2 ZDHHC17 ZG16B
Entrez ID		63891	10422
HPRD ID		11499	12170
Ensembl ID		ENSG00000164068	ENSG00000130560
Uniprot IDs		Q5XPI4	A0A140VK64 Q9BSL1
PDB IDs		2MA6	2DAI
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Nuclear Lamina Nucleus Nucleoplasm Ubiquitin Protein Ligase Binding Nuclear Membrane Lamin Filament Nuclear Pore Localization Ubiquitin Conjugating Enzyme Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Nuclear Inner Membrane SMAD Protein Complex Negative Regulation Of Biosynthetic Process Heteromeric SMAD Protein Complex Negative Regulation Of RNA Metabolic Process Nuclear Envelope Negative Regulation Of Cell Population Proliferation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nuclear Lamina Protein Localization To Nuclear Envelope I-SMAD Binding Negative Regulation Of Metabolic Process Epigenetic Regulation Of Gene Expression Intracellular Signal Transduction Nuclear Envelope Organization Negative Regulation Of Transcription By RNA Polymerase II Response To Growth Factor Nuclear Matrix SMAD Protein Signal Transduction Disordered Domain Specific Binding Protein Ubiquitination Negative Regulation Of Epithelial Cell Apoptotic Process Nuclear Migration Heterochromatin Formation Amyloid Fibril Formation Ionotropic Glutamate Receptor Signaling Pathway Neuron Maturation Cell Surface Receptor Signaling Pathway Nucleus Localization Negative Regulation Of Fibroblast Proliferation Protein Modification By Small Protein Conjugation Aortic Valve Morphogenesis Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression Ligand-gated Ion Channel Signaling Pathway Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion	Ubiquitin Protein Ligase Activity Modification-dependent Protein Catabolic Process Protein Ubiquitination Collateral Sprouting In Absence Of Injury Regulation Of Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Catabolic Process Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Regulation Of Protein Metabolic Process Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Macromolecule Catabolic Process Protein Catabolic Process Positive Regulation Of Aggrephagy Transferase Activity Post-translational Protein Modification Negative Regulation Of Potassium Ion Export Across Plasma Membrane Positive Regulation Of Protein Catabolic Process Apoptotic Process Positive Regulation Of Metabolic Process Programmed Cell Death Cell Death Negative Regulation Of Signal Transduction Regulation Of Proteolysis Proteolysis Protein Targeting To Vacuole Potassium Channel Inhibitor Activity Ubiquitin-protein Transferase Activity Regulation Of Programmed Cell Death Identical Protein Binding Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Signal Transduction Establishment Of Protein Localization To Vacuole Protein Targeting To Vacuole Involved In Autophagy Positive Regulation Of Signal Transduction Regulation Of MAPK Cascade Ubiquitin Protein Ligase Binding Positive Regulation Of Macromolecule Metabolic Process Segment Specification Proteasomal Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Collateral Sprouting Regulation Of Developmental Growth Catabolic Process Receptor Catabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?