RNF123 and TMPO

Number of citations of the paper that reports this interaction (PubMedID 29676528)
0

Data Source:
BioGRID (enzymatic study)

		RNF123	TMPO
Description		ring finger protein 123	thymopoietin
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GO Annotations	Cellular Component	Cytoplasm Cytosol Nuclear Membrane	Chromatin Nucleus Nuclear Envelope Nuclear Inner Membrane Chromosome Cytoplasm Membrane Nuclear Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	DNA Binding Protein Binding Lamin Binding Cadherin Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Canonical NF-kappaB Signal Transduction Protein Ubiquitination Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Maturation
Pathways		Ub-specific processing proteases Antigen processing: Ubiquitination & Proteasome degradation	RHOA GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle
Drugs
Diseases
GWAS		Age at first birth ( 27798627) Appendicular lean mass ( 33097823) Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Depressive symptoms (binary sum-score) ( 31530331) Extremely high intelligence ( 29520040) Hemoglobin levels ( 32327693) Household income ( 31844048) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Multisite chronic pain ( 31194737) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Metabolite levels ( 23823483)
Interacting Genes		18 interacting genes: APP CDKN1B EMD GRIK1 LCOR LMNA LMNB1 MORC3 MTDH RB1 SMAD2 SMAD9 TMPO UBAC1 UBC UBE2D1 UBE2D2 UBE2W	27 interacting genes: ABL1 AKAP8L BANF1 CDK1 CEBPA CLK1 CSNK2A1 FXR1 GMCL1 GOLM1 HDAC3 KLHL6 LMNA LMNB1 LMNB2 OGT OIP5 RB1 RNF123 SGTA SGTB SRC SRPK2 STOM SUMO2 USP7 WEE2-AS1
Entrez ID		63891	7112
HPRD ID		11499	01777
Ensembl ID		ENSG00000164068	ENSG00000120802
Uniprot IDs		Q5XPI4	G5E972 P42166 P42167 Q59G12
PDB IDs		2MA6	1GJJ 1H9E 1H9F 8FN7 8FND 8FNG 8FNH 8FNJ 8FNL 8FNM 8FNN 8FNO 8FNP 8FNQ
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Nuclear Lamina Nucleus Nucleoplasm Ubiquitin Protein Ligase Binding Nuclear Membrane Lamin Filament Nuclear Pore Localization Ubiquitin Conjugating Enzyme Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Nuclear Inner Membrane SMAD Protein Complex Negative Regulation Of Biosynthetic Process Heteromeric SMAD Protein Complex Negative Regulation Of RNA Metabolic Process Nuclear Envelope Negative Regulation Of Cell Population Proliferation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nuclear Lamina Protein Localization To Nuclear Envelope I-SMAD Binding Negative Regulation Of Metabolic Process Epigenetic Regulation Of Gene Expression Intracellular Signal Transduction Nuclear Envelope Organization Negative Regulation Of Transcription By RNA Polymerase II Response To Growth Factor Nuclear Matrix SMAD Protein Signal Transduction Disordered Domain Specific Binding Protein Ubiquitination Negative Regulation Of Epithelial Cell Apoptotic Process Nuclear Migration Heterochromatin Formation Amyloid Fibril Formation Ionotropic Glutamate Receptor Signaling Pathway Neuron Maturation Cell Surface Receptor Signaling Pathway Nucleus Localization Negative Regulation Of Fibroblast Proliferation Protein Modification By Small Protein Conjugation Aortic Valve Morphogenesis Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression Ligand-gated Ion Channel Signaling Pathway Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion	Nuclear Pore Localization Nucleus Organization Negative Regulation Of Gene Expression, Epigenetic Organelle Organization Chromatin Organization Nuclear Envelope Organization Negative Regulation Of Gene Expression Heterochromatin Formation Negative Regulation Of Macromolecule Metabolic Process Epigenetic Regulation Of Gene Expression Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Chromatin Remodeling Regulation Of Proteasomal Protein Catabolic Process PML Body Nuclear Lamina Negative Regulation Of Macromolecule Biosynthetic Process Protein Localization To Nuclear Envelope Negative Regulation Of Biosynthetic Process Nuclear Matrix Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Structural Constituent Of Nuclear Lamina TRC Complex Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein-containing Complex Localization Regulation Of Gene Expression Protein Localization To Organelle Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Nuclear Migration Regulation Of Cellular Localization Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteolysis Nucleus Localization Cellular Response To Fluid Shear Stress Nucleus Regulation Of Protein Catabolic Process Positive Regulation Of Catabolic Process Nuclear Envelope Rb-E2F Complex Lamin Filament Positive Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process
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