MMP1 and BSG

Number of citations of the paper that reports this interaction (PubMedID 10706100)
0

Data Source:
HPRD (in vitro, in vivo)

		MMP1	BSG
Description		matrix metallopeptidase 1	basigin (Ok blood group)
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix	Golgi Membrane Photoreceptor Outer Segment Photoreceptor Inner Segment Acrosomal Membrane Mitochondrion Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Focal Adhesion Membrane Basolateral Plasma Membrane Axon Sarcolemma Melanosome Cell Projection Extracellular Exosome
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Virus Receptor Activity Protein Binding D-mannose Binding Carbohydrate Binding Signaling Receptor Activity Cadherin Binding Cell-cell Adhesion Mediator Activity
	Biological Process	Proteolysis Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Positive Regulation Of Protein-containing Complex Assembly Cellular Response To UV-A	Angiogenesis Neural Retina Development Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell Surface Receptor Signaling Pathway Axon Guidance Embryo Implantation Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Endothelial Cell Migration Neutrophil Chemotaxis Positive Regulation Of Interleukin-6 Production Odontogenesis Of Dentin-containing Tooth Response To Peptide Hormone Photoreceptor Cell Maintenance Positive Regulation Of Viral Entry Into Host Cell Response To Mercury Ion Decidualization Symbiont Entry Into Host Cell Response To CAMP Endothelial Tube Morphogenesis Dendrite Self-avoidance Protein Localization To Plasma Membrane Positive Regulation Of Matrix Metallopeptidase Secretion Neuron Projection Extension
Pathways		Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Basigin interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-4 and Interleukin-13 signaling	Degradation of the extracellular matrix Basigin interactions Integrin cell surface interactions Proton-coupled monocarboxylate transport Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) Aspirin ADME
Drugs		Marimastat CGS-27023 N-[3-(N'-HYDROXYCARBOXAMIDO)-2-(2-METHYLPROPYL)-PROPANOYL]-O-TYROSINE-N-METHYLAMIDE METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID [[1-[N-HYDROXY-ACETAMIDYL]-3-METHYL-BUTYL]-CARBONYL-LEUCINYL]-ALANINE ETHYL ESTER N-HYDROXY-2-[4-(4-PHENOXY-BENZENESULFONYL)-TETRAHYDRO-PYRAN-4-YL]-ACETAMIDE
Diseases		Choriocarcinoma
GWAS		Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058)	Alzheimer's disease (late onset) ( 28714976)
Interacting Genes		17 interacting genes: ACAN BCAN BSG CCL13 CCL2 CCL7 CD44 CMA1 COL2A1 IGFBP3 ITGA2 MMP7 SERPINA3 SOX8 TFPI TIMP1 TNFSF11	21 interacting genes: ADRB2 AQP6 CACNA1C CAV1 CCR4 CHRM3 CRBN F2RL1 HGS MMP1 OGT PDLIM7 PPIA PPIL2 PPP2R1B SLC16A1 SLC16A13 SLC16A3 SLC2A4 TMEM14B UBC
Entrez ID		4312	682
HPRD ID		00384	00176
Ensembl ID		ENSG00000196611	ENSG00000172270
Uniprot IDs		B4DN15 P03956 Q53G95	P35613 Q54A51
PDB IDs		1AYK 1CGE 1CGF 1CGL 1HFC 1SU3 2AYK 2CLT 2J0T 2TCL 3AYK 3SHI 4AUO 4AYK 966C	3B5H 3I84 3I85 3QQN 3QR2 4U0Q 5X0T 5XF0 6LYY 6LZ0 7CKO 7CKR 7DA5 7DAA 7DCE 7XY8 8XEJ
Enriched GO Terms of Interacting Partners?		Extracellular Space Extracellular Region Extracellular Matrix Myeloid Leukocyte Migration Leukocyte Chemotaxis Hyaluronic Acid Binding Granulocyte Migration Cell Chemotaxis Regulation Of Cell Migration Cell Migration Granulocyte Chemotaxis Cytokine Activity Monocyte Chemotaxis Eosinophil Migration Eosinophil Chemotaxis Regulation Of Cell Motility Leukocyte Migration CCR Chemokine Receptor Binding Cell Motility Regulation Of Locomotion CCR2 Chemokine Receptor Binding Animal Organ Morphogenesis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Chemotaxis Chemokine Activity Positive Regulation Of Locomotion Locomotion Cytokine-mediated Signaling Pathway Perineuronal Net Chemokine-mediated Signaling Pathway Regulation Of Cell Morphogenesis Extracellular Matrix Organization Extracellular Structure Organization Cell Adhesion Regulation Of Anatomical Structure Morphogenesis Homeostatic Process Inflammatory Response Cartilage Development Mononuclear Cell Migration Peptidase Inhibitor Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Regulation Of Apoptotic Process Regulation Of Lymphocyte Chemotaxis Anatomical Structure Morphogenesis Cell Surface Receptor Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Cell Shape Positive Regulation Of Chemotaxis Central Nervous System Development	Monocarboxylic Acid Transmembrane Transporter Activity Lactate:proton Symporter Activity Vascular Process In Circulatory System Plasma Membrane Lactate Transport Pyruvate Transmembrane Transport Pyruvate Transport Lactate Transmembrane Transporter Activity Regulation Of Muscle Contraction Regulation Of Transport Regulation Of Smooth Muscle Contraction Circulatory System Process Receptor-mediated Endocytosis Positive Regulation Of Cytosolic Calcium Ion Concentration Transmembrane Transporter Activity Lactate Transport Pyruvate Catabolic Process Lactate Transmembrane Transport Regulation Of Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Protein Ubiquitination Positive Regulation Of Cell Communication Positive Regulation Of Signaling Membrane Negative Regulation Of Post-translational Protein Modification Basolateral Plasma Membrane Regulation Of Muscle System Process System Process Symporter Activity Positive Regulation Of Cold-induced Thermogenesis Regulation Of Protein Secretion Positive Regulation Of Cellular Component Biogenesis Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Signal Transduction Positive Regulation Of Secretion By Cell Regulation Of System Process Regulation Of Cardiac Muscle Cell Action Potential Negative Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Secretion Regulation Of Secretion By Cell Monocarboxylic Acid Transport Brown Fat Cell Differentiation Import Into Cell Blood Vessel Diameter Maintenance Regulation Of Cell Communication Positive Regulation Of Protein-containing Complex Disassembly G Protein-coupled Receptor Activity Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Apical Plasma Membrane Ligand-gated Ion Channel Signaling Pathway Regulation Of Cold-induced Thermogenesis Regulation Of Tube Size
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